Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC38 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 10578.143 | uM | 308.37710 | 997.79880 | -0.0975 | -0.5173 | 0.6049 | 0.2789 | 0.9834 | 1.6935 | |
| HCC38 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 11850.143 | uM | 173.320 | 240.01390 | 0.0956 | -0.0902 | 0.5094 | 0.2951 | 0.9876 | 2.1044 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7854.017 | uM | 95.97870 | 1000.00000 | -0.5133 | -0.8772 | 0.4323 | 0.5201 | 0.9440 | 1.3102 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9453.017 | uM | 204.98770 | 867.09230 | -0.5306 | -0.7483 | 0.6344 | 0.4287 | 0.9866 | 1.2279 | |
| HCC38 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9469.131 | uM | 492.70010 | 1000.00000 | -0.6025 | -0.6339 | 1.1567 | 0.3652 | 0.9907 | 1.0627 | |
| HCC38 | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 11850.158 | uM | 2.43840 | 3.85560 | -0.8302 | -0.8605 | 2.1846 | 0.4535 | 0.9902 | 1.9855 | |
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7469.066 | uM | inf | inf | 0.9727 | 0.9727 | 0.0000 | 0.0128 | -0.0529 | 2.0057 | |
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 10418.066 | uM | inf | inf | 0.9039 | 0.9039 | 0.0000 | 0.0609 | 0.4077 | 1.1532 | |
| HCC38 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7468.066 | uM | 106.34480 | 711.3920 | 0.7048 | -1.0000 | 0.5781 | 0.0720 | 0.6582 | 1.3940 | |
| HCC38 | TNBC | Basal B | AG1478 | EGFR | ErbB | 9453.019 | uM | inf | inf | 0.9233 | 0.9233 | 0.0000 | 0.0531 | 0.3590 | 1.1486 | |
| HCC38 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7854.016 | uM | 13.49420 | 13.19450 | -0.1917 | 0.0530 | 4.9889 | 0.1947 | 0.8974 | 0.9074 | |
| HCC38 | TNBC | Basal B | AG1478 | EGFR | ErbB | 9028.016 | uM | 92.84250 | 219.73640 | 0.1700 | -1.0000 | 1.2752 | 0.0911 | 0.9647 | 1.2348 | |
| HCC38 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 10578.141 | uM | inf | inf | 0.7463 | 0.7463 | 0.0000 | 0.1127 | 0.4612 | 1.5679 | |
| HCC38 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 11850.158 | uM | inf | 1.29810 | 0.7689 | 0.7997 | 5.0000 | 0.0680 | 0.7890 | 1.9855 | |
| HCC38 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7468.073 | uM | 7.29580 | 11.06170 | -0.5675 | -0.5930 | 1.8791 | 0.3904 | 0.9858 | 1.4124 | |
| HCC38 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10418.072 | uM | 28.61970 | 33.98370 | -0.6797 | -0.6803 | 5.0000 | 0.1999 | 0.9948 | 1.1007 | |
| HCC38 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10578.072 | uM | 39.8090 | 48.96280 | -0.6724 | -0.6824 | 4.1586 | 0.1476 | 0.9977 | 1.6597 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7469.074 | uM | 0.06193 | 0.09293 | -0.9586 | -0.9333 | 2.5945 | 1.1124 | 0.9992 | 1.9843 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7469.074 | uM | 0.06193 | 0.09293 | -0.9586 | -0.9333 | 2.5945 | 1.1124 | 0.9992 | 1.9843 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14909.203 | uM | 0.01538 | 0.01897 | -0.9320 | -0.9266 | 4.9991 | 1.2416 | 0.9995 | 1.3791 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14909.203 | uM | 0.01538 | 0.01897 | -0.9320 | -0.9266 | 4.9991 | 1.2416 | 0.9995 | 1.3791 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7468.074 | uM | 0.05152 | 0.07779 | -0.9826 | -0.9779 | 2.6299 | 1.1803 | 0.9995 | 1.5027 | |
| HCC38 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7468.074 | uM | 0.05152 | 0.07779 | -0.9826 | -0.9779 | 2.6299 | 1.1803 | 0.9995 | 1.5027 | |
| HCC38 | TNBC | Basal B | Bosutinib | Src | nRTK | 11850.145 | uM | 1.13470 | 1.59980 | -0.7354 | -0.7043 | 2.5590 | 0.5723 | 0.9960 | 2.1492 | |
| HCC38 | TNBC | Basal B | Bosutinib | Src | nRTK | 10578.145 | uM | 0.79029 | 1.31180 | -0.8086 | -0.7766 | 1.8496 | 0.6145 | 0.9976 | 1.6766 |