Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Bosutinib | Src | nRTK | 12400.17 | uM | 0.95624 | 1.36560 | -0.7750 | -0.7429 | 2.5554 | 0.4530 | 0.9957 | 1.1992 | |
| HCC70 | TNBC | Basal A | Bosutinib | Src | nRTK | 10873.145 | uM | 0.9820 | 2.45510 | -0.8901 | -0.8689 | 1.0991 | 0.5283 | 0.9970 | 1.2454 | |
| HCC70 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7857.011 | uM | 12.96930 | 16.26290 | -0.9756 | -0.9722 | 4.7718 | 0.6272 | 0.9991 | 1.0477 | |
| HCC70 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 7860.011 | uM | 17.88260 | 22.44810 | -0.9954 | -0.9945 | 4.8154 | 0.6186 | 0.9991 | 0.7135 | |
| HCC70 | TNBC | Basal A | Carboplatin | DNA cross-linker | DNA cross-linker | 9501.011 | uM | 13.60390 | 16.92010 | -0.9869 | -0.9881 | 4.9994 | 0.6318 | 0.9993 | 0.9301 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7856.018 | uM | inf | inf | 0.8811 | 0.8811 | 0.0000 | 0.0121 | 0.4683 | 0.9388 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7857.042 | uM | inf | 0.00139 | 0.7456 | 0.7944 | 5.0000 | 0.1040 | 0.8457 | 1.1910 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 7860.042 | uM | 1.41750 | 6.04060 | 0.6742 | -0.9996 | 0.7577 | 0.0164 | 0.8799 | 0.6736 | |
| HCC70 | TNBC | Basal A | Cetuximab | EGFR | ErbB | 9501.026 | uM | inf | 0.01283 | 0.4925 | 0.5840 | 1.2619 | 0.0978 | 0.8957 | 0.7616 | |
| HCC70 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 7856.018 | uM | 3.24150 | 49.7860 | -0.9805 | -1.0000 | 0.4022 | 0.7437 | 0.8488 | 0.9388 | ||
| HCC70 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 9501.026 | uM | 0.63315 | 10.41250 | -0.9773 | -1.0000 | 0.3924 | 0.9469 | 0.8501 | 0.7616 | ||
| HCC70 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 9501.03 | uM | inf | inf | -0.9987 | -0.9987 | 0.0000 | 0.4685 | 0.5497 | 0.6902 | |
| HCC70 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7860.017 | uM | 2.40830 | 3.01010 | -0.9990 | -0.9990 | 4.9226 | 0.6684 | 0.9951 | 0.6196 | |
| HCC70 | TNBC | Basal A | Cisplatin | DNA cross-linker | DNA cross-linker | 7857.017 | uM | 1.60450 | 2.36240 | -0.9732 | -0.9789 | 2.8032 | 0.7284 | 0.9991 | 1.1840 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 7860.043 | uM | inf | inf | 0.9822 | 0.9822 | 0.0000 | 0.0201 | 0.2254 | 0.7488 | |
| HCC70 | TNBC | Basal A | CPT-11 | TOP1 | TOP | 9501.121 | uM | 12.38040 | 17.6920 | -0.9538 | -0.9706 | 3.0220 | 0.2061 | 0.9962 | 0.7121 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 10873.155 | uM | 0.11517 | 0.08168 | 0.1060 | 0.1377 | 0.9376 | 0.4610 | 0.7766 | 1.2787 | |
| HCC70 | TNBC | Basal A | Dactolisib | PI3K | PI3K | 12400.155 | uM | 0.13114 | 0.13888 | -0.0575 | -0.0800 | 2.5868 | 0.4826 | 0.9924 | 1.2558 | |
| HCC70 | TNBC | Basal A | Dichloroacetate | PDK | PDK | 12714.176 | uM | 0.59743 | 168.50620 | 0.2521 | -1.0000 | 0.1947 | 0.2769 | 0.5769 | 0.3108 | |
| HCC70 | TNBC | Basal A | Disulfiram | Proteasome | Proteasome | 12714.174 | uM | inf | inf | 1.0210 | 1.0210 | 0.0000 | 0.2086 | 0.0000 | 0.3306 | |
| HCC70 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 9501.002 | uM | 0.00302 | 0.00582 | -0.5255 | -0.5680 | 1.1563 | 0.9048 | 0.9833 | 1.0082 | |
| HCC70 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 12714.002 | uM | 0.00244 | 0.00428 | -0.7131 | -0.7666 | 1.6607 | 1.0519 | 0.9839 | 0.4328 | |
| HCC70 | TNBC | Basal A | Docetaxel | TUBB | TUBB | 7857.002 | uM | 0.00680 | 0.00914 | -0.2632 | -0.3133 | 1.6486 | 0.7292 | 0.9850 | 1.1921 | |
| HCC70 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 7860.043 | uM | 3.99210 | 5.72270 | -0.9934 | -0.9983 | 3.0475 | 0.4398 | 0.9815 | 0.7488 | |
| HCC70 | TNBC | Basal A | Doxorubicin | TOP2 | TOP | 9501.121 | uM | 0.26936 | 0.55094 | -0.9997 | -1.0000 | 1.5353 | 0.7865 | 0.9962 | 0.7121 |