Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7864.042 | uM | inf | inf | 0.9446 | 0.9446 | 0.0000 | -0.0078 | -0.0792 | 1.4812 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7863.018 | uM | inf | inf | 0.9678 | 0.9678 | 0.0000 | 0.0287 | 0.0694 | 2.0946 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7862.042 | uM | inf | inf | 0.8300 | 0.8300 | 0.0000 | 0.0340 | 0.2783 | 1.2756 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7861.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.8485 | |
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7863.018 | uM | 93.13020 | 1000.00000 | -0.7605 | -0.9551 | 0.4500 | 0.3964 | 0.6501 | 2.0946 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9511.034 | uM | 13.69580 | 390.94370 | -0.9614 | -1.0000 | 0.3278 | 0.5398 | 0.7280 | 1.1177 | ||
| Hs 578T | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7861.018 | uM | 846.11220 | 1000.00000 | -0.9642 | -0.6530 | 5.0000 | 0.1076 | 0.8583 | 0.8485 | ||
| Hs 578T | TNBC | Basal B | Chloroquine | 12622.177 | uM | 5.16760 | 8.74240 | -0.6678 | -0.7210 | 1.6981 | 0.2810 | 0.9997 | 2.5433 | |||
| Hs 578T | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7863.017 | uM | inf | 2.42270 | 0.1619 | 0.5028 | 4.9973 | 0.1923 | 0.6588 | 1.9568 | |
| Hs 578T | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7862.017 | uM | 7.34780 | 15.84620 | -0.9530 | -1.0000 | 1.4295 | 0.5016 | 0.9788 | 1.3198 | |
| Hs 578T | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7864.017 | uM | 8.55240 | 17.46430 | -0.8895 | -0.9609 | 1.5018 | 0.4529 | 0.9837 | 1.6561 | |
| Hs 578T | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7861.017 | uM | 6.17520 | 9.16460 | -0.4540 | -0.4589 | 1.6494 | 0.3832 | 0.9920 | 1.8068 | |
| Hs 578T | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9511.021 | uM | 16.3020 | 24.45550 | -0.8220 | -0.8295 | 2.4113 | 0.3461 | 0.9963 | 1.3466 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7863.007 | uM | inf | 52.97460 | 0.7011 | 0.5937 | 3.0757 | -0.0133 | 0.8737 | 1.4578 | |
| Hs 578T | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9511.034 | uM | 13.67290 | 28.5270 | -0.6245 | -1.0000 | 1.4938 | 0.2054 | 0.9797 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Dactolisib | PI3K | PI3K | 10694.146 | uM | inf | 0.59404 | 0.9321 | 0.9482 | 4.9147 | 0.0057 | 0.5761 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12622.176 | uM | inf | inf | 0.9947 | 0.9947 | 0.0000 | -0.0101 | -0.9347 | 2.5005 | |
| Hs 578T | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 12622.174 | uM | 7.57420 | 16.26170 | -0.8300 | -1.0000 | 1.4378 | 0.2836 | 0.9641 | 2.4358 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 7864.002 | uM | 0.00202 | 0.00368 | -0.4182 | -0.4089 | 1.0008 | 0.8906 | 0.9829 | 1.5910 | |
| Hs 578T | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9511.002 | uM | 0.00153 | 0.00209 | -0.4596 | -0.4491 | 2.0361 | 0.9639 | 0.9856 | 1.1960 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7863.007 | uM | 3.32340 | 4.93410 | -0.5852 | -0.6262 | 2.0549 | 0.3704 | 0.9741 | 1.4578 | |
| Hs 578T | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9511.034 | uM | 0.10151 | 0.39355 | -0.9726 | -0.8874 | 0.7531 | 0.7665 | 0.9843 | 1.1177 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7862.017 | uM | 0.34445 | 1.15410 | -0.9973 | -0.9467 | 0.8787 | 0.7815 | 0.9793 | 1.3198 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7863.017 | uM | 0.45185 | 1.31370 | -0.9777 | -0.8120 | 0.9039 | 0.6605 | 0.9795 | 1.9568 | |
| Hs 578T | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7864.017 | uM | 0.36656 | 0.99035 | -0.9870 | -0.8360 | 0.9889 | 0.7176 | 0.9860 | 1.6561 |