Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | AG1478 | EGFR | ErbB | 7864.016 | uM | inf | inf | 0.9663 | 0.9663 | 0.0000 | 0.0494 | 0.0019 | 1.4893 | |
| Hs 578T | TNBC | Basal B | AG1478 | EGFR | ErbB | 7863.016 | uM | 277.8570 | 950.06040 | 0.6475 | -1.0000 | 0.8936 | 0.0611 | 0.8641 | 1.7699 | |
| Hs 578T | TNBC | Basal B | AG1478 | EGFR | ErbB | 7861.016 | uM | 53.58820 | 340.84020 | 0.1558 | -1.0000 | 0.5938 | 0.1756 | 0.8868 | 2.0473 | |
| Hs 578T | TNBC | Basal B | AG1478 | EGFR | ErbB | 7862.016 | uM | 28.12640 | 62.54760 | -0.5904 | -1.0000 | 1.3746 | 0.1654 | 0.9947 | 1.3229 | |
| Hs 578T | TNBC | Basal B | AS-252424 | PI3K | PI3K | 10694.153 | uM | inf | 6.79170 | 0.5918 | 0.5917 | 5.0000 | 0.0456 | 0.9716 | 2.2940 | |
| Hs 578T | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10379.072 | uM | inf | 42.9060 | 0.6437 | 0.6432 | 4.7121 | -0.0013 | 0.8993 | 2.1304 | |
| Hs 578T | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10694.072 | uM | 52.03210 | 56.00940 | -0.2061 | -0.2124 | 4.8066 | 0.1363 | 0.9654 | 2.1922 | |
| Hs 578T | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7471.072 | uM | 47.02520 | 55.23050 | -0.5854 | -0.5927 | 4.8610 | 0.1075 | 0.9980 | 2.2270 | |
| Hs 578T | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7472.072 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.2269 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7472.074 | uM | 0.10869 | 0.13354 | -0.6783 | -0.6933 | 4.2243 | 0.9765 | 0.990 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7472.074 | uM | 0.10869 | 0.13354 | -0.6783 | -0.6933 | 4.2243 | 0.9765 | 0.990 | 1.5922 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 15310.203 | uM | 0.00955 | 0.01538 | -0.6099 | -0.6332 | 1.7176 | 1.0855 | 0.9927 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 15310.203 | uM | 0.00955 | 0.01538 | -0.6099 | -0.6332 | 1.7176 | 1.0855 | 0.9927 | 2.4683 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7473.074 | uM | 0.15419 | 0.18046 | -0.6339 | -0.5980 | 5.0000 | 0.8594 | 0.9948 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7473.074 | uM | 0.15419 | 0.18046 | -0.6339 | -0.5980 | 5.0000 | 0.8594 | 0.9948 | 2.5364 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7475.074 | uM | 0.09190 | 0.11119 | -0.8733 | -0.7961 | 4.9999 | 0.9925 | 0.9970 | 2.4793 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7475.074 | uM | 0.09190 | 0.11119 | -0.8733 | -0.7961 | 4.9999 | 0.9925 | 0.9970 | 2.4793 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7474.074 | uM | 0.08045 | 0.09811 | -0.7172 | -0.7007 | 4.4139 | 0.9511 | 0.9971 | 2.6218 | |
| Hs 578T | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7474.074 | uM | 0.08045 | 0.09811 | -0.7172 | -0.7007 | 4.4139 | 0.9511 | 0.9971 | 2.6218 | |
| Hs 578T | TNBC | Basal B | Bosutinib | Src | nRTK | 10694.145 | uM | 1.84520 | 4.1620 | -0.8541 | -0.8943 | 1.2607 | 0.4870 | 0.9970 | 2.2732 | |
| Hs 578T | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 12622.177 | uM | 0.23724 | 0.28366 | -0.7666 | -0.7219 | 5.0000 | 0.6272 | 0.9991 | 2.5433 | |
| Hs 578T | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7864.011 | uM | 69.26270 | 94.45560 | -0.9059 | -0.9143 | 3.3516 | 0.4668 | 0.9647 | 1.4831 | |
| Hs 578T | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7862.011 | uM | 70.85350 | 97.69110 | -0.9439 | -0.9494 | 3.3136 | 0.4682 | 0.9738 | 1.3695 | |
| Hs 578T | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7863.011 | uM | 70.86910 | 95.26480 | -0.7849 | -0.7891 | 3.2014 | 0.3770 | 0.9948 | 2.0237 | |
| Hs 578T | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9511.021 | uM | 76.14350 | 113.82930 | -0.8699 | -0.8750 | 2.5160 | 0.3515 | 0.9976 | 1.3466 |