Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HMT-3522 T4-2 | Unknown | Unknown | GSK461364 | PLK1 | PLK | 10147.001 | uM | 0.01271 | 0.01330 | -0.7694 | -0.1257 | 4.9998 | 0.6366 | 0.7859 | 2.5313 | |
| HMT-3522 T4-2 | Unknown | Unknown | GSK923295 | CENPE | Kinesin | 10147.001 | uM | 0.15986 | 2.13050 | -0.7068 | -1.0000 | 0.4242 | 0.5157 | 0.9130 | 2.5313 | |
| HMT-3522 T4-2 | Unknown | Unknown | Oxaliplatin | DNA cross-linker | DNA cross-linker | 10147.021 | uM | 12.51650 | 80.4150 | -0.8372 | -1.0000 | 0.5906 | 0.3998 | 0.9198 | 2.1856 | |
| HMT-3522 T4-2 | Unknown | Unknown | Taxol | TUBB | TUBB | 10147.002 | uM | 0.00858 | 0.00955 | -0.3666 | -0.3520 | 4.9998 | 0.8604 | 0.9984 | 1.9641 | |
| HMT-3522 T4-2 | Unknown | Unknown | Trametinib | MEK | MAPK | 10147.012 | uM | 0.00098 | 0.00091 | -0.1956 | 0.0632 | 1.9761 | 0.7030 | 0.8821 | 1.6544 | |
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7861.016 | uM | inf | inf | 0.8285 | 0.8285 | 0.0000 | 0.1095 | 0.3323 | 2.0473 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7864.016 | uM | inf | 1.79080 | 0.6594 | 0.6722 | 5.0000 | 0.1436 | 0.6701 | 1.4893 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7863.016 | uM | inf | 2.23280 | 0.6663 | 0.7322 | 2.0323 | 0.1121 | 0.8555 | 1.7699 | ||
| Hs 578T | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7862.016 | uM | inf | 3.5820 | 0.6087 | 0.7072 | 5.0000 | 0.0671 | 0.8712 | 1.3229 | ||
| Hs 578T | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7863.05 | uM | 0.09232 | 0.11295 | -0.6226 | -0.3457 | 2.6051 | 0.6822 | 0.9707 | 1.6873 | |
| Hs 578T | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7862.04 | uM | 0.10362 | 0.14784 | -0.6949 | -0.4857 | 1.9097 | 0.7442 | 0.9809 | 1.4556 | |
| Hs 578T | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7864.05 | uM | 0.09689 | 0.12009 | -0.5415 | -0.4141 | 2.8102 | 0.7319 | 0.990 | 1.5353 | |
| Hs 578T | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7864.037 | uM | 0.12650 | 0.16117 | -0.3959 | -0.3057 | 1.9692 | 0.6470 | 0.9950 | 1.7830 | |
| Hs 578T | TNBC | Basal B | 2-deoxyglucose | 12622.177 | uM | 837.94870 | 677.66110 | 0.3271 | 0.3269 | 4.9962 | 0.0868 | 0.9950 | 2.5433 | |||
| Hs 578T | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 10694.143 | uM | 460.62880 | 1000.00000 | 0.0380 | -0.3067 | 0.6171 | 0.2328 | 0.9879 | 2.2259 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7864.017 | uM | 56.13570 | 165.52520 | -0.5570 | -0.6452 | 0.7664 | 0.6230 | 0.9857 | 1.6561 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7862.017 | uM | 19.90020 | 39.44990 | -0.6175 | -0.5998 | 1.1520 | 0.7981 | 0.9882 | 1.3198 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7863.017 | uM | 60.73160 | 142.34260 | -0.4110 | -0.4799 | 0.7899 | 0.5666 | 0.9892 | 1.9568 | |
| Hs 578T | TNBC | Basal B | 5-FU | TYMS | TYMS | 7861.017 | uM | 240.67720 | 1000.00000 | -0.3407 | -0.5858 | 0.5444 | 0.4087 | 0.9955 | 1.8068 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7473.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0434 | -6.5378 | 2.3582 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7472.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0221 | -0.4172 | 1.8363 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7474.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0000 | -0.0022 | 2.7948 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7471.066 | uM | inf | inf | 0.9596 | 0.9596 | 0.0000 | 0.0065 | 0.3052 | 2.2865 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 7475.066 | uM | inf | inf | 0.8654 | 0.8654 | 0.0000 | -0.0314 | 0.4305 | 2.7689 | |
| Hs 578T | TNBC | Basal B | AG1024 | IGF1R | RTK | 10379.066 | uM | inf | 8.96430 | 0.9086 | 0.9084 | 4.5819 | 0.0097 | 0.5911 | 2.3931 |