Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

Data Columns

  • 17 Data Columns
Name Description Display Name Data Type Unit Precision Readout Type Replicate Comments
cell
Cell reagent
 Cell cell
clinicalSubtype
Clinical subtype of cell line
 Clinical Subtype Text
transcriptionalSubtype
Transcriptional subtype of cell line
 Transcriptional Subtype Text
smallMolecule
Small molecule perturbagen
 Small Molecule small_molecule
antibody
Antibody perturbagen
 Antibody antibody
perturbagenTarget Perturbagen Target Text
perturbagenClass Perturbagen Class Text
biologicalReplicateID Biological Replicate ID Text
concUnit
Concentration unit for GR50 and GEC50
 Conc Unit Text
gR50
Perturbagen concentration at which GR(c)=0.5
 GR50 Text
gEC50
Perturbagen concentration that results in 50% efficacy
 GEC50 Text
gRmax
Normalized growth inhibition rate at the highest tested perturbagen concentration
 GRmax Numeric 4
gRinf
Asymptotic value (concentration = infinity) for the sigmoidal curve fit to the dose-response data
 GRinf Numeric 4
gRHillCoefficient
Maximal slope of the dose-response curve
 GR Hill Coefficient Numeric 4
gRAOC
Integral of GR(c) over the range of concentrations tested
 GR_AOC Numeric 4
gRR2
r^2 for the sigmoidal curve fit to the dose-response data
 GR r2 Text
nominalDivisionRate
Estimated number of divisions of the DMSO-treated control over the course of the assay
 Nominal Division Rate Numeric 4
  • 17 Data Columns