Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
HMT-3522 S1
Unknown
Unknown
 Epirubicin
TOP2
TOP
7911.017
uM
0.39366
0.66727
 -0.9915 -0.7303 1.7063 0.7212
0.9778
 1.6151
HMT-3522 S1
Unknown
Unknown
 Gefitinib
EGFR
ErbB
7911.016
uM
0.28452
0.39154
 -0.3343 -0.2142 1.1165 0.3885
0.9785
 1.3310
HMT-3522 S1
Unknown
Unknown
 Geldanamycin
HSP90
HSP90
10124.012
uM
0.00305
0.00272
 0.0483 0.1305 2.6086 0.7062
0.9824
 1.9565
HMT-3522 S1
Unknown
Unknown
 Gemcitabine
DNA replication
DNA replication
7911.011
uM
0.09997
0.07414
 0.0634 0.0993 0.7407 0.5128
0.9333
 1.6150
HMT-3522 S1
Unknown
Unknown
 GSK1070916
AURK
AURK
7911.001
uM
0.37690
2.46370
 -0.9585 -1.0000 0.5852 0.4855
0.8325
 1.2005
HMT-3522 S1
Unknown
Unknown
 GSK1070916
AURK
AURK
10124.001
uM
1.0290
4.57770
 -0.7178 -1.0000 0.7361 0.3920
0.9705
 2.1861
HMT-3522 S1
Unknown
Unknown
 GSK461364
PLK1
PLK
10124.001
uM
0.15881
2.68710
 -0.8812 -1.0000 0.3884 0.5111
0.7829
 2.1861
HMT-3522 S1
Unknown
Unknown
 GSK461364
PLK1
PLK
7911.001
uM
0.00305
0.00372
 -0.9614 -0.4179 3.0660 0.9553
0.8201
 1.2005
HMT-3522 S1
Unknown
Unknown
 GSK923295
CENPE
Kinesin
10124.001
uM
1.43510
5.99740
 -0.8122 -1.0000 0.7682 0.3995
0.8893
 2.1861
HMT-3522 S1
Unknown
Unknown
 GSK923295
CENPE
Kinesin
7911.001
uM
0.48448
1.82110
 -0.9500 -1.0000 0.8297 0.5219
0.9328
 1.2005
HMT-3522 S1
Unknown
Unknown
 Oxaliplatin
DNA cross-linker
DNA cross-linker
10124.021
uM
22.02040
29.56470
 -0.3607 -0.3701 1.8806 0.3292
0.9871
 1.9744
HMT-3522 S1
Unknown
Unknown
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7911.011
uM
29.49610
52.85950
 -0.7650 -0.7983 1.6356 0.3254
0.9969
 1.6150
HMT-3522 S1
Unknown
Unknown
 Taxol
TUBB
TUBB
10124.002
uM
0.01656
0.0140
 0.0784 0.1372 1.9107 0.5113
0.9918
 2.0795
HMT-3522 S1
Unknown
Unknown
 Topotecan
TOP1
TOP
7911.007
uM
27.23380
87.39960
 -0.1449 -1.0000 0.9422 0.1736
0.9448
 1.5549
HMT-3522 S1
Unknown
Unknown
 Trametinib
MEK
MAPK
10124.012
uM
0.00074
0.00053
 0.2498 0.2658 2.3479 0.6006
0.9280
 1.9565
HMT-3522 S1
Unknown
Unknown
 Trametinib
MEK
MAPK
7911.05
uM
0.00476
0.00398
 0.2765 0.2954 4.9996 0.4656
0.990
 1.7938
HMT-3522 S1
Unknown
Unknown
 Vinorelbine
TUBB
TUBB
7911.018
uM
0.01299
0.69981
 -0.8468 -1.0000 0.2756 0.7368
0.8495
 1.8543
HMT-3522 T4-2
Unknown
Unknown
 Carboplatin
DNA cross-linker
DNA cross-linker
10147.021
uM
93.59350
168.07060
 -0.7489 -0.8071 1.6414 0.3010
0.9969
 2.1856
HMT-3522 T4-2
Unknown
Unknown
 CGC-11047
Polyamine analogue
10147.034
uM
68.7640
433.96040
 -0.7197 -1.0000 0.5963 0.4941
0.9012
 2.3470
HMT-3522 T4-2
Unknown
Unknown
 Cisplatin
DNA cross-linker
DNA cross-linker
10147.021
uM
11.54940
24.46710
 -0.7574 -0.8526 1.3256 0.3834
0.9859
 2.1856
HMT-3522 T4-2
Unknown
Unknown
 CPT-11
TOP1
TOP
10147.034
uM
8.54950
28.80180
 -0.4345 -1.0000 0.9045 0.1804
0.9739
 2.3470
HMT-3522 T4-2
Unknown
Unknown
 Docetaxel
TUBB
TUBB
10147.002
uM
0.0020
0.00255
 -0.2150 -0.2640 1.7622 0.8198
0.9777
 1.9641
HMT-3522 T4-2
Unknown
Unknown
 Doxorubicin
TOP2
TOP
10147.034
uM
0.18096
0.47126
 -0.8841 -0.8712 1.0540 0.7427
0.9957
 2.3470
HMT-3522 T4-2
Unknown
Unknown
 Geldanamycin
HSP90
HSP90
10147.012
uM
0.00797
0.01106
 -0.2179 -0.1828 0.9491 0.8162
0.9567
 1.6544
HMT-3522 T4-2
Unknown
Unknown
 GSK1070916
AURK
AURK
10147.001
uM
0.87845
4.38920
 -0.8035 -1.0000 0.6829 0.4108
0.9215
 2.5313