Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LY2 | HR+ | Luminal | AG1478 | EGFR | ErbB | 9536.019 | uM | inf | 198.1860 | 0.8846 | 0.6294 | 4.6350 | 0.0088 | 0.6984 | 1.5595 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12319.165 | uM | inf | inf | 0.3097 | 0.3097 | 0.0000 | 0.2478 | 0.0039 | 0.9117 | |
| LY2 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 10816.153 | uM | inf | inf | 0.2645 | 0.2645 | 0.0000 | 0.1603 | 0.3698 | 0.7704 | |
| LY2 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10380.072 | uM | inf | 10.7010 | 0.8875 | 0.9010 | 4.9982 | 0.0004 | 0.6793 | 1.4455 | |
| LY2 | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 10816.072 | uM | 32.02410 | 48.47810 | -0.9790 | -1.0000 | 2.6497 | 0.2198 | 0.9585 | 0.7870 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14791.203 | uM | 0.03919 | 0.26102 | -0.8691 | -1.0000 | 0.5794 | 0.8757 | 0.9857 | 1.5910 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 14791.203 | uM | 0.03919 | 0.26102 | -0.8691 | -1.0000 | 0.5794 | 0.8757 | 0.9857 | 1.5910 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15315.203 | uM | 0.03498 | 0.17196 | -0.7361 | -0.7924 | 0.5963 | 0.8286 | 0.9865 | 1.2762 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 15315.203 | uM | 0.03498 | 0.17196 | -0.7361 | -0.7924 | 0.5963 | 0.8286 | 0.9865 | 1.2762 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7477.074 | uM | 1.42280 | 2.72180 | -0.8830 | -0.8161 | 1.4920 | 0.5590 | 0.9936 | 0.6324 | |
| LY2 | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7477.074 | uM | 1.42280 | 2.72180 | -0.8830 | -0.8161 | 1.4920 | 0.5590 | 0.9936 | 0.6324 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 12319.17 | uM | 1.74560 | 2.09550 | -0.7562 | -0.7467 | 5.0000 | 0.4985 | 0.8163 | 0.4684 | |
| LY2 | HR+ | Luminal | Bosutinib | Src | nRTK | 10816.145 | uM | 2.79490 | 3.39070 | -0.8804 | -0.8139 | 4.9999 | 0.5009 | 0.9897 | 0.7766 | |
| LY2 | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12627.177 | uM | 0.24704 | 0.34171 | -0.9574 | -0.9521 | 3.2862 | 0.6940 | 0.9990 | 1.2910 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9536.011 | uM | 51.12240 | 145.68290 | -0.9018 | -1.0000 | 1.0491 | 0.3755 | 0.9649 | 1.2640 | |
| LY2 | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 10264.011 | uM | 53.18280 | 98.53430 | -0.6128 | -0.6689 | 1.3771 | 0.3634 | 0.9946 | 1.3983 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7865.018 | uM | inf | inf | -0.1870 | -0.1870 | 0.0000 | 0.5240 | -0.0010 | 1.1920 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 10264.026 | uM | inf | inf | 0.9706 | 0.9706 | 0.0000 | -0.0006 | 0.1039 | 1.5047 | |
| LY2 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9536.006 | uM | inf | inf | 0.9716 | 0.9716 | 0.0000 | 0.0671 | 0.1220 | 1.2564 | |
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7865.018 | uM | inf | inf | -0.9931 | -0.9931 | 0.0000 | 1.0189 | 0.3416 | 1.1920 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 10264.026 | uM | 455.10120 | 1000.00000 | -0.7152 | -0.7162 | 1.1292 | 0.3424 | 0.7193 | 1.5047 | ||
| LY2 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9536.006 | uM | 849.19620 | 1000.00000 | -0.9039 | -0.6322 | 4.9999 | 0.3005 | 0.7201 | 1.2564 | ||
| LY2 | HR+ | Luminal | Chloroquine | 12627.177 | uM | 8.11120 | 14.22040 | -0.9290 | -1.0000 | 1.9568 | 0.2711 | 0.9966 | 1.2910 | |||
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7865.017 | uM | 12.22310 | 25.10090 | -0.9549 | -1.0000 | 1.5267 | 0.4553 | 0.9488 | 1.9138 | |
| LY2 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10264.131 | uM | 6.67580 | 20.59690 | -0.6200 | -0.8300 | 0.8683 | 0.3839 | 0.9935 | 1.4548 |