Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF 10A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
7485.074
uM
1.85990
5.45550
 -0.5031 -0.6624 0.7840 0.4506
0.9854
 3.5413
MCF 10A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
15317.203
uM
0.14753
0.47503
 -0.6051 -0.6981 0.7473 0.6761
0.9901
 2.6269
MCF 10A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
15317.203
uM
0.14753
0.47503
 -0.6051 -0.6981 0.7473 0.6761
0.9901
 2.6269
MCF 10A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
14747.203
uM
0.01725
0.02760
 -0.7124 -0.7369 1.9275 1.0771
0.9946
 2.4861
MCF 10A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
14747.203
uM
0.01725
0.02760
 -0.7124 -0.7369 1.9275 1.0771
0.9946
 2.4861
MCF 10A
NM
Basal B
 Bosutinib
Src
nRTK
11056.145
uM
1.67930
1.75260
 -0.0825 -0.0412 1.8507 0.3072
0.9938
 2.8383
MCF 10A
NM
Basal B
 Bromopyruvic acid
Hexokinase II
Metabolism
12944.177
uM
0.02046
0.02513
 -0.9555 -0.8962 4.9999 1.0376
0.9972
 2.0477
MCF 10A
NM
Basal B
 Carboplatin
DNA cross-linker
DNA cross-linker
9551.011
uM
262.77390
523.69010
 -0.6668 -1.0000 1.5931 0.1869
0.9861
 2.7742
MCF 10A
NM
Basal B
 Carboplatin
DNA cross-linker
DNA cross-linker
7867.011
uM
81.19560
218.39390
 -0.7660 -0.9997 1.1101 0.2898
0.9971
 2.3684
MCF 10A
NM
Basal B
 Carboplatin
DNA cross-linker
DNA cross-linker
7870.011
uM
75.40490
158.2450
 -0.7997 -0.8959 1.3851 0.3213
0.9980
 2.1270
MCF 10A
NM
Basal B
 Cetuximab
EGFR
ErbB
7868.018
uM
inf
inf
 0.9199 0.9199 0.0000 -0.0068
0.4328
 2.1110
MCF 10A
NM
Basal B
 Cetuximab
EGFR
ErbB
9551.026
uM
inf
0.14350
 0.7282 0.7281 4.9914 0.0090
0.9280
 2.6508
MCF 10A
NM
Basal B
 Cetuximab
EGFR
ErbB
7867.042
uM
0.82087
0.24212
 0.5210 0.3793 1.1638 0.0459
0.9580
 2.3427
MCF 10A
NM
Basal B
 Cetuximab
EGFR
ErbB
7870.018
uM
0.39912
0.12872
 0.4513 0.4038 1.4562 0.0600
0.9769
 2.2478
MCF 10A
NM
Basal B
 CGC-11047
Polyamine analogue
9551.026
uM
185.91980
1000.00000
 -0.6377 -0.8853 0.6057 0.3813
0.7752
 2.6508
MCF 10A
NM
Basal B
 CGC-11047
Polyamine analogue
7870.018
uM
265.4420
530.97710
 -0.7548 -0.8469 1.4293 0.4668
0.8849
 2.2478
MCF 10A
NM
Basal B
 CGC-11047
Polyamine analogue
7868.018
uM
166.63690
683.31190
 -0.7886 -1.0000 0.7785 0.4292
0.9325
 2.1110
MCF 10A
NM
Basal B
 Chloroquine
12944.177
uM
17.43960
43.85410
 -0.2432 -1.0000 1.1914 0.2250
0.7720
 2.0477
MCF 10A
NM
Basal B
 Cisplatin
DNA cross-linker
DNA cross-linker
7870.017
uM
11.44630
21.16180
 -0.8833 -0.9296 1.7095 0.3866
0.9853
 2.0447
MCF 10A
NM
Basal B
 Cisplatin
DNA cross-linker
DNA cross-linker
9551.017
uM
15.85230
49.78760
 -0.7233 -1.0000 0.9600 0.2741
0.9919
 2.5886
MCF 10A
NM
Basal B
 Cisplatin
DNA cross-linker
DNA cross-linker
7867.017
uM
11.26790
23.16950
 -0.7724 -0.8532 1.3811 0.3666
0.9935
 2.5255
MCF 10A
NM
Basal B
 CPT-11
TOP1
TOP
7870.007
uM
2.94510
24.99790
 -0.3107 -1.0000 0.5137 0.3076
0.9833
 2.0710
MCF 10A
NM
Basal B
 CPT-11
TOP1
TOP
9551.121
uM
4.7690
9.35580
 -0.0029 -0.2467 0.5952 0.2392
0.9884
 2.7416
MCF 10A
NM
Basal B
 Dactolisib
PI3K
PI3K
11056.155
uM
0.06430
0.05945
 0.0706 0.1611 4.9600 0.4208
0.9490
 2.9269
MCF 10A
NM
Basal B
 Dichloroacetate
PDK
PDK
12944.176
uM
inf
0.00165
 0.9070 0.9353 1.3443 0.0350
0.7319
 2.5862