Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | GSK923295 | CENPE | Kinesin | 7871.001 | uM | 0.05773 | 0.05552 | -0.3537 | 0.0328 | 1.7394 | 0.4399 | 0.8919 | 1.0311 | |
| MCF 10F | NM | - | Ibandronate | FDPS | 12254.143 | uM | 177.1340 | 398.44880 | -0.0080 | -0.3886 | 0.7093 | 0.1825 | 0.9772 | 1.4110 | ||
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 12254.157 | uM | inf | 0.08854 | 0.8275 | 0.8456 | 4.9373 | 0.0612 | 0.9149 | 1.6969 | |
| MCF 10F | NM | - | IKK16 | IKK | NFKB | 7486.1 | uM | 3.82890 | 5.00590 | -0.9988 | -0.9986 | 4.0953 | 0.3766 | 0.9977 | 1.0281 | |
| MCF 10F | NM | - | Imatinib | ABL/KIT/PDGFR | nRTK | 7486.092 | uM | 9.76170 | 22.29110 | -0.9978 | -1.0000 | 1.3305 | 0.5043 | 0.9957 | 1.1266 | |
| MCF 10F | NM | - | Imatinib | ABL/KIT/PDGFR | nRTK | 7487.09 | uM | 39.39260 | 56.10840 | -0.9891 | -0.9905 | 3.0881 | 0.3364 | 0.9984 | 1.5226 | |
| MCF 10F | NM | - | Ispinesib | KSP | Kinesin | 7487.067 | uM | 0.03384 | 0.45356 | -0.9677 | -1.0000 | 0.4233 | 0.6721 | 0.8878 | 1.3523 | |
| MCF 10F | NM | - | Ixabepilone | TUBB | TUBB | 7486.095 | uM | 0.00829 | 0.10436 | -0.9993 | -1.0000 | 0.4338 | 0.9187 | 0.9127 | 0.9448 | |
| MCF 10F | NM | - | JNK-IN-5A | JNK | JNK | 12254.144 | uM | inf | inf | 0.8974 | 0.8974 | 0.0000 | 0.0190 | 0.2706 | 1.8842 | |
| MCF 10F | NM | - | L-779450 | BRAF | MAPK | 12254.161 | uM | 14.10120 | 16.03370 | -0.4145 | -0.4208 | 4.7543 | 0.1039 | 0.9948 | 1.3991 | |
| MCF 10F | NM | - | Lapatinib | EGFR/HER2 | ErbB | 7486.098 | uM | 13.11290 | 16.15790 | -0.0393 | -0.9204 | 5.0000 | 0.0412 | 0.9871 | 0.9165 | |
| MCF 10F | NM | - | LBH589 | HDAC | HDAC | 12254.154 | uM | 0.93382 | 1.34260 | -0.6126 | -0.5614 | 2.0731 | 0.3518 | 0.9942 | 1.6307 | |
| MCF 10F | NM | - | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12254.154 | uM | 2.04870 | 3.43670 | -0.7731 | -0.8008 | 1.8482 | 0.3182 | 0.9927 | 1.6307 | |
| MCF 10F | NM | - | Mebendazole | 13750.174 | uM | 3.91920 | 96.55890 | -0.0155 | -1.0000 | 0.3429 | 0.2885 | 0.9278 | 1.4282 | |||
| MCF 10F | NM | - | Methotrexate | DHFR | Metabolism | 7487.084 | uM | 0.09336 | 0.07754 | 0.2750 | 0.3024 | 5.0000 | 0.4595 | 0.9971 | 1.3396 | |
| MCF 10F | NM | - | Methylglyoxal | 13672.184 | uM | 325.82880 | 1000.00000 | -0.9500 | -0.9161 | 0.9284 | 0.6111 | 0.9793 | 2.3721 | |||
| MCF 10F | NM | - | MG-132 | Proteasome | Proteasome | 14161.189 | uM | 0.07893 | 0.11362 | -0.9316 | -0.5920 | 2.1442 | 0.8378 | 0.8784 | 1.1003 | |
| MCF 10F | NM | - | MG-132 | Proteasome | Proteasome | 14161.189 | uM | 0.07893 | 0.11362 | -0.9316 | -0.5920 | 2.1442 | 0.8378 | 0.8784 | 1.1003 | |
| MCF 10F | NM | - | MG-132 | Proteasome | Proteasome | 12254.145 | uM | 0.08265 | 0.17690 | -0.7329 | -0.7389 | 1.1924 | 0.7782 | 0.9946 | 1.7869 | |
| MCF 10F | NM | - | MG-132 | Proteasome | Proteasome | 12254.145 | uM | 0.08265 | 0.17690 | -0.7329 | -0.7389 | 1.1924 | 0.7782 | 0.9946 | 1.7869 | |
| MCF 10F | NM | - | Pevonedistat | NAE1 | NAE1 | 12254.135 | uM | 0.74058 | 0.71573 | 0.0331 | 0.0139 | 0.8259 | 0.3490 | 0.9943 | 1.6637 | |
| MCF 10F | NM | - | Nelfinavir | 13750.174 | uM | 9.41490 | 15.28370 | -0.7109 | -1.0000 | 2.2675 | 0.2028 | 0.9819 | 1.4282 | |||
| MCF 10F | NM | - | Nilotinib | ABL | nRTK | 12254.145 | uM | inf | inf | 0.8912 | 0.8912 | 0.0000 | 0.0017 | 0.4681 | 1.7869 | |
| MCF 10F | NM | - | NSC 663284 | CDC25 | CDC | 12254.152 | uM | 2.78020 | 5.66370 | -0.8559 | -0.9155 | 1.4624 | 0.5340 | 0.9964 | 1.8382 | |
| MCF 10F | NM | - | NU6102 | CDK1/2 | CDK | 12254.147 | uM | 12.25660 | 19.72940 | -0.9129 | -1.0000 | 2.3078 | 0.1912 | 0.9898 | 1.4316 |