Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF12A
NM
Basal B
 Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14164.189
uM
0.04818
0.11047
 -0.9933 -1.0000 1.3238 1.0570
0.9810
 0.7884
MCF12A
NM
Basal B
 Z-Leu-Leu-Norvalinal
Proteasome
Proteasome
14637.189
uM
0.24531
0.42597
 -0.6468 -0.6575 1.5210 0.6758
0.9965
 2.7087
MCF12A
NM
Basal B
 ZM-447439
AURK
AURK
12365.169
uM
inf
0.64004
 0.6059 0.6378 3.4420 0.1185
0.9695
 2.1831
MCF12A
NM
Basal B
 ZM-447439
AURK
AURK
10817.15
uM
1.17690
0.58024
 0.4320 0.4359 2.9038 0.1795
0.9924
 1.3689
MCF7
HR+
Luminal
 (Z)-4-Hydroxytamoxifen
ESR1
9583.132
uM
inf
inf
 0.9409 0.9409 0.0000 0.0291
0.4029
 1.2070
MCF7
HR+
Luminal
 (Z)-4-Hydroxytamoxifen
ESR1
7875.016
uM
36.8150
155.18220
 -0.0965 -1.0000 0.7636 0.1967
0.9078
 1.6229
MCF7
HR+
Luminal
 (Z)-4-Hydroxytamoxifen
ESR1
7874.016
uM
inf
7.93870
 0.5977 0.4146 0.2796 0.1875
0.9565
 1.5947
MCF7
HR+
Luminal
 17-AAG
HSP90
HSP90
7875.037
uM
0.28268
0.59846
 -0.3040 -0.2566 0.5523 0.4787
0.9356
 1.6059
MCF7
HR+
Luminal
 17-AAG
HSP90
HSP90
9583.037
uM
0.66417
10.24910
 -0.3728 -0.8905 0.3738 0.4534
0.9544
 1.2109
MCF7
HR+
Luminal
 17-AAG
HSP90
HSP90
7874.05
uM
0.99901
2.00190
 -0.1226 -0.2306 0.5455 0.3724
0.9554
 1.5863
MCF7
HR+
Luminal
 2-deoxyglucose
12657.177
uM
inf
999.99930
 0.6366 0.6079 2.0818 0.0688
0.8695
 0.9257
MCF7
HR+
Luminal
 5-DFUR
TYMS
TYMS
10997.143
uM
130.47580
202.88370
 -0.2157 -0.2790 1.0043 0.3746
0.9420
 0.6416
MCF7
HR+
Luminal
 5-FU
TYMS
TYMS
9583.017
uM
53.35090
343.93660
 -0.4881 -0.7382 0.4866 0.5746
0.9772
 1.0456
MCF7
HR+
Luminal
 5-FU
TYMS
TYMS
7875.017
uM
53.25230
282.92860
 -0.4727 -0.6921 0.5202 0.5757
0.9845
 1.6110
MCF7
HR+
Luminal
 AG1024
IGF1R
RTK
7493.066
uM
inf
inf
 0.9557 0.9557 0.0000 -0.0077
0.2568
 1.3293
MCF7
HR+
Luminal
 AG1024
IGF1R
RTK
7492.066
uM
47.18890
294.29280
 0.5623 -1.0000 0.6002 0.0968
0.7890
 1.6656
MCF7
HR+
Luminal
 AG1478
EGFR
ErbB
7875.016
uM
inf
inf
 0.8772 0.8772 0.0000 0.0456
0.0592
 1.6229
MCF7
HR+
Luminal
 AG1478
EGFR
ErbB
7874.016
uM
158.7510
501.25860
 0.4802 -0.9956 0.9530 0.1002
0.7131
 1.5947
MCF7
HR+
Luminal
 AS-252424
PI3K
PI3K
10997.153
uM
17.62820
126.89280
 0.3418 -1.0000 0.5566 0.1499
0.8586
 1.0771
MCF7
HR+
Luminal
 Baicalein
Lipoxygenase
Metabolism
10997.072
uM
166.88260
170.0210
 0.4988 -0.0483 4.9473 0.0366
0.9490
 1.3599
MCF7
HR+
Luminal
 Baicalein
Lipoxygenase
Metabolism
7493.073
uM
67.21380
85.42130
 -0.6522 -0.7731 3.8987 0.1135
0.9967
 1.4116
MCF7
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7492.074
uM
0.12125
0.35573
 -0.7615 -0.6679 0.7882 0.7583
0.9532
 1.4222
MCF7
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7492.074
uM
0.12125
0.35573
 -0.7615 -0.6679 0.7882 0.7583
0.9532
 1.4222
MCF7
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7493.074
uM
0.06609
0.28016
 -0.8876 -0.8233 0.6738 0.8883
0.9598
 1.1549
MCF7
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
7493.074
uM
0.06609
0.28016
 -0.8876 -0.8233 0.6738 0.8883
0.9598
 1.1549