Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF7
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14755.203
uM
0.05228
0.24906
 -0.4352 -0.5144 0.4531 0.6585
0.9768
 2.0371
MCF7
HR+
Luminal
 Bortezomib
Proteasome
Proteasome
14755.203
uM
0.05228
0.24906
 -0.4352 -0.5144 0.4531 0.6585
0.9768
 2.0371
MCF7
HR+
Luminal
 Bosutinib
Src
nRTK
10997.145
uM
2.71340
1.5220
 0.1886 0.1825 0.7852 0.2876
0.9481
 1.3945
MCF7
HR+
Luminal
 Bromopyruvic acid
Hexokinase II
Metabolism
12657.177
uM
0.29531
0.37321
 -0.9869 -0.9795 4.6335 0.6710
0.9993
 0.9257
MCF7
HR+
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
7875.011
uM
119.23580
266.07560
 -0.4874 -0.7291 1.1205 0.2641
0.9896
 1.6960
MCF7
HR+
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
10073.021
uM
269.68110
451.01230
 -0.5048 -0.7268 1.7453 0.1442
0.9932
 0.5665
MCF7
HR+
Luminal
 Carboplatin
DNA cross-linker
DNA cross-linker
9583.011
uM
230.27290
685.40770
 -0.3344 -1.0000 1.0072 0.1701
0.9943
 1.0421
MCF7
HR+
Luminal
 Cetuximab
EGFR
ErbB
7874.018
uM
inf
inf
 0.9611 0.9611 0.0000 -0.0261
-0.1994
 1.6506
MCF7
HR+
Luminal
 Cetuximab
EGFR
ErbB
9583.026
uM
inf
inf
 0.9966 0.9966 0.0000 0.0156
-0.0344
 1.2731
MCF7
HR+
Luminal
 Cetuximab
EGFR
ErbB
7875.018
uM
inf
inf
 0.9316 0.9316 0.0000 -0.0136
0.3967
 1.6565
MCF7
HR+
Luminal
 CGC-11047
Polyamine analogue
7874.018
uM
89.31090
1000.00000
 -0.5749 -0.8076 0.3980 0.3580
0.6990
 1.6506
MCF7
HR+
Luminal
 CGC-11047
Polyamine analogue
9583.026
uM
321.32760
1000.00000
 -0.2230 -0.3704 0.4883 0.2592
0.7368
 1.2731
MCF7
HR+
Luminal
 CGC-11047
Polyamine analogue
10073.034
uM
869.1580
1000.00000
 -0.8708 -0.5080 5.0000 0.1985
0.7391
 0.5531
MCF7
HR+
Luminal
 CGC-11047
Polyamine analogue
7875.018
uM
123.00360
811.46460
 -0.6784 -1.0000 0.5823 0.3989
0.9523
 1.6565
MCF7
HR+
Luminal
 Chloroquine
12657.177
uM
9.42830
16.30480
 -0.9509 -1.0000 2.0057 0.2759
0.9873
 0.9257
MCF7
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
7875.017
uM
11.31540
27.19110
 -0.7177 -0.8649 1.1454 0.3441
0.9926
 1.6110
MCF7
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
9583.017
uM
22.88870
52.45060
 -0.5721 -0.8256 1.1758 0.2417
0.9938
 1.0456
MCF7
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
10073.021
uM
28.52850
40.93960
 -0.5545 -0.5863 2.1483 0.2058
0.9970
 0.5665
MCF7
HR+
Luminal
 CPT-11
TOP1
TOP
9583.121
uM
23.16940
44.48550
 -0.5055 -1.0000 1.6841 0.1448
0.9877
 1.0648
MCF7
HR+
Luminal
 CPT-11
TOP1
TOP
7875.007
uM
19.71080
36.69120
 -0.5559 -1.0000 1.7680 0.1317
0.9915
 1.4906
MCF7
HR+
Luminal
 CPT-11
TOP1
TOP
10073.034
uM
21.23530
33.4110
 -0.7457 -1.0000 2.4240 0.1525
0.9977
 0.5531
MCF7
HR+
Luminal
 Dactolisib
PI3K
PI3K
10997.155
uM
inf
inf
 0.5015 0.5015 0.0000 0.2181
0.5284
 1.3159
MCF7
HR+
Luminal
 Dichloroacetate
PDK
PDK
12657.176
uM
inf
inf
 0.9410 0.9410 0.0000 0.0143
0.5190
 1.0711
MCF7
HR+
Luminal
 Disulfiram
Proteasome
Proteasome
12657.174
uM
31.26840
65.89180
 -0.0114 -1.0000 1.4738 0.1306
0.9489
 1.0776
MCF7
HR+
Luminal
 Docetaxel
TUBB
TUBB
9583.002
uM
0.01155
0.00912
 0.1347 0.1212 1.1780 0.4761
0.9809
 1.2590