Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 7877.001 | uM | 0.29497 | 4.43060 | -0.4638 | -1.0000 | 0.4055 | 0.4308 | 0.9496 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1070916 | AURK | AURK | 7876.001 | uM | 2.19470 | 25.38020 | -0.1142 | -1.0000 | 0.4488 | 0.2721 | 0.9821 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7494.09 | uM | inf | 0.13394 | 0.6716 | 0.6248 | 0.2260 | 0.1968 | 0.6056 | 1.0823 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7494.07 | uM | 6.41350 | 11.47930 | -0.9740 | -1.0000 | 1.8872 | 0.3893 | 0.9532 | 0.9405 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7494.098 | uM | 5.9880 | 11.28540 | -0.9693 | -1.0000 | 1.7335 | 0.3423 | 0.9843 | 0.9748 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7877.001 | uM | 0.00193 | 0.00217 | -0.9020 | -0.3982 | 5.0000 | 1.0156 | 0.7247 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7876.001 | uM | 0.01745 | 0.01705 | 0.0520 | 0.0536 | 5.0000 | 0.5335 | 0.8087 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK461364 | PLK1 | PLK | 10077.001 | uM | 9.22450 | 11.42610 | -0.8911 | -0.9019 | 4.8165 | 0.1998 | 0.9388 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 10077.001 | uM | 1.67260 | 85.25550 | 0.1160 | -0.9861 | 0.2771 | 0.3084 | 0.8652 | 0.5941 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 7877.001 | uM | 0.09747 | 0.11533 | -0.6510 | -0.6581 | 4.9937 | 0.7738 | 0.9741 | 0.4366 | |
| MDA-MB-134-VI | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 7876.001 | uM | 0.10556 | 0.11460 | -0.2144 | -0.2543 | 5.0000 | 0.5587 | 0.990 | 0.9806 | |
| MDA-MB-134-VI | HR+ | Luminal | GW843682X | PLK | PLK | 10519.139 | uM | 7.75930 | 7.28030 | 0.1368 | 0.1364 | 4.9997 | 0.1091 | 0.9541 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | Ibandronate | FDPS | 10998.143 | uM | 46.59130 | 86.85540 | -0.6572 | -0.6538 | 1.3426 | 0.4008 | 0.9685 | 0.5976 | ||
| MDA-MB-134-VI | HR+ | Luminal | Ibandronate | FDPS | 12206.143 | uM | 77.9420 | 123.18860 | -0.4069 | -0.4388 | 1.3762 | 0.2775 | 0.9933 | 1.0676 | ||
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10519.139 | uM | inf | inf | 0.7060 | 0.7060 | 0.0000 | 0.1007 | 0.4680 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10998.151 | uM | inf | 2.77990 | 0.5525 | 0.6582 | 4.9915 | 0.0658 | 0.8042 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12206.157 | uM | 56.76520 | 999.92190 | 0.4849 | -0.6424 | 0.2880 | 0.1624 | 0.8847 | 0.9766 | |
| MDA-MB-134-VI | HR+ | Luminal | IKK16 | IKK | NFKB | 10419.093 | uM | 6.01090 | 7.4880 | -0.9996 | -1.0000 | 5.0000 | 0.3264 | 0.9975 | 0.5719 | |
| MDA-MB-134-VI | HR+ | Luminal | IKK16 | IKK | NFKB | 10519.1 | uM | 3.94990 | 4.91110 | -0.9842 | -0.9856 | 4.9998 | 0.3855 | 0.9978 | 1.0071 | |
| MDA-MB-134-VI | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7494.09 | uM | 28.9390 | 56.73670 | -0.9774 | -1.0000 | 1.6318 | 0.4702 | 0.9584 | 1.0823 | |
| MDA-MB-134-VI | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7494.067 | uM | 0.04041 | 0.07152 | -0.9951 | -0.6394 | 1.4428 | 0.7754 | 0.9486 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7494.094 | uM | 0.00016 | 0.02576 | -0.9888 | -1.0000 | 0.2157 | 1.2454 | 0.6904 | 0.9794 | |
| MDA-MB-134-VI | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 10419.095 | uM | 0.00214 | 0.00359 | -0.9978 | -0.5283 | 1.3964 | 1.0840 | 0.9050 | 0.7505 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 10998.144 | uM | inf | inf | 0.6051 | 0.6051 | 0.0000 | 0.1603 | 0.4066 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | JNK-IN-5A | JNK | JNK | 12206.144 | uM | 2.29990 | 1.87070 | 0.0857 | 0.3220 | 5.0000 | 0.2425 | 0.6370 | 0.9811 |