Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Selumetinib | MEK | MAPK | 12594.155 | uM | inf | 1.06540 | 0.7747 | 0.8100 | 5.0000 | 0.0570 | 0.8924 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Sigma A6730 | AKT | AKT | 12594.165 | uM | 14.42930 | 18.00520 | -0.9472 | -0.9508 | 4.8113 | 0.1719 | 0.9959 | 1.4798 | |
| MDA-MB-157 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7495.069 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0388 | 0.0179 | 0.5089 | |
| MDA-MB-157 | TNBC | Basal B | Sirolimus | MTOR | MTOR | 7879.068 | uM | inf | 42.49340 | 0.8431 | 0.8429 | 4.6142 | 0.0070 | 0.7219 | 1.8348 | |
| MDA-MB-157 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7496.085 | uM | inf | inf | 0.5054 | 0.5054 | 0.0000 | 0.1591 | 0.2284 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7498.084 | uM | 425.10560 | 948.95960 | -0.0440 | -1.0000 | 1.3681 | 0.1285 | 0.9443 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7498.067 | uM | inf | inf | -0.9434 | -0.9434 | 0.0000 | 0.3215 | 0.4385 | 1.1346 | |
| MDA-MB-157 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7496.067 | uM | 6.0810 | 7.5510 | -0.9823 | -0.9750 | 4.9967 | 0.4702 | 0.9930 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7495.067 | uM | 4.22520 | 6.95350 | -0.9987 | -1.0000 | 2.2053 | 0.5144 | 0.9976 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | TAPI-0 | TACE/Collagenase | 7496.096 | uM | inf | inf | 0.7820 | 0.7820 | 0.0000 | 0.0905 | 0.4104 | 1.0771 | ||
| MDA-MB-157 | TNBC | Basal B | Taxol | TUBB | TUBB | 10093.002 | uM | 0.00477 | 0.00766 | -0.8190 | -0.7899 | 2.0005 | 1.1679 | 0.9965 | 0.9296 | |
| MDA-MB-157 | TNBC | Basal B | TCS 2312 | CHK1 | CHK | 12594.152 | uM | 0.18047 | 0.21835 | -0.9179 | -0.7965 | 4.9999 | 0.6900 | 0.9896 | 1.3085 | |
| MDA-MB-157 | TNBC | Basal B | TCS PIM-1 1 | Pim kinase | PIM | 12594.135 | uM | inf | inf | 0.8522 | 0.8522 | 0.0000 | 0.0205 | 0.3273 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Temsirolimus | MTOR | MTOR | 12594.168 | uM | 26.46490 | 39.82910 | -0.9566 | -1.0000 | 2.6876 | 0.2914 | 0.9332 | 1.2703 | |
| MDA-MB-157 | TNBC | Basal B | Topotecan | TOP1 | TOP | 7879.077 | uM | 0.48708 | 0.87470 | -0.5235 | -0.5063 | 1.1946 | 0.5926 | 0.9862 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Torkinib | 15321.211 | uM | 0.03892 | 0.91831 | -0.4972 | -0.9420 | 0.3351 | 0.6929 | 0.9944 | 2.7437 | |||
| MDA-MB-157 | TNBC | Basal B | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12594.169 | uM | 4.1810 | 16.62640 | -0.6267 | -1.0000 | 0.7958 | 0.3446 | 0.9651 | 1.4097 | |
| MDA-MB-157 | TNBC | Basal B | TPCA-1 | IKK | NFKB | 7496.093 | uM | 7.4640 | 4.15410 | 0.4346 | 0.4733 | 4.9999 | 0.1418 | 0.9329 | 0.9777 | |
| MDA-MB-157 | TNBC | Basal B | Trametinib | MEK | MAPK | 10093.012 | uM | inf | inf | 0.3958 | 0.3958 | 0.0000 | 0.4812 | 0.3474 | 1.0064 | |
| MDA-MB-157 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7496.065 | uM | 15.89350 | 28.96770 | -0.9812 | -0.9990 | 1.8291 | 0.8612 | 0.9848 | 0.9526 | |
| MDA-MB-157 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7498.065 | uM | 20.05210 | 33.62560 | -0.9459 | -0.9550 | 2.0662 | 0.7874 | 0.9950 | 1.1827 | |
| MDA-MB-157 | TNBC | Basal B | Trichostatin A | HDAC | HDAC | 7495.065 | uM | 15.09490 | 25.91660 | -0.9648 | -0.9616 | 1.9846 | 0.7955 | 0.9993 | 1.2645 | |
| MDA-MB-157 | TNBC | Basal B | Triciribine | AKT | AKT | 7496.074 | uM | 0.25073 | 0.12334 | 0.2486 | 0.2039 | 0.7383 | 0.3858 | 0.8703 | 1.3504 | |
| MDA-MB-157 | TNBC | Basal B | Triciribine | AKT | AKT | 7495.074 | uM | 3.20830 | 73.02160 | 0.0644 | -1.0000 | 0.3516 | 0.2590 | 0.9067 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Triciribine | AKT | AKT | 7498.074 | uM | 1.78980 | 0.19938 | 0.4151 | 0.4073 | 0.7678 | 0.2286 | 0.9912 | 1.0877 |