Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-157
TNBC
Basal B
 Nilotinib
ABL
nRTK
12594.17
uM
inf
inf
 0.8144 0.8144 0.0000 0.0415
0.5417
 1.2180
MDA-MB-157
TNBC
Basal B
 NSC 663284
CDC25
CDC
12594.152
uM
1.39410
1.72870
 -0.9655 -0.9662 5.0000 0.6396
0.9983
 1.3085
MDA-MB-157
TNBC
Basal B
 NU6102
CDK1/2
CDK
12594.147
uM
50.22110
62.36680
 -0.1529 -0.9768 5.0000 0.0681
0.9913
 1.4279
MDA-MB-157
TNBC
Basal B
 Nutlin 3a
MDM2
MDM2
7496.066
uM
21.68290
24.0640
 -0.2540 -0.2717 4.1658 0.0861
0.9882
 1.1616
MDA-MB-157
TNBC
Basal B
 Nutlin 3a
MDM2
MDM2
7498.066
uM
52.31020
57.59380
 0.1639 -0.2693 4.4773 0.0466
0.9895
 1.0752
MDA-MB-157
TNBC
Basal B
 Olomoucine II
CDK1
CDK
12594.147
uM
6.37180
7.39410
 -0.5551 -0.5519 4.9983 0.3117
0.9980
 1.4279
MDA-MB-157
TNBC
Basal B
 Omipalisib
PI3K
PI3K
7498.086
uM
0.21570
1.32580
 -0.2991 -0.6031 0.4357 0.4648
0.9859
 1.0436
MDA-MB-157
TNBC
Basal B
 Omipalisib
PI3K
PI3K
7496.087
uM
0.39866
0.55923
 -0.1326 -0.1673 0.8527 0.3733
0.9990
 1.0123
MDA-MB-157
TNBC
Basal B
 Oxaliplatin
DNA cross-linker
DNA cross-linker
10093.021
uM
0.34452
7.5390
 -0.9885 -1.0000 0.3560 0.7952
0.7484
 0.9172
MDA-MB-157
TNBC
Basal B
 Oxamflatin
HDAC
HDAC
12594.147
uM
0.86339
2.5250
 -0.9475 -1.0000 1.0237 0.5313
0.9951
 1.4279
MDA-MB-157
TNBC
Basal B
 PD 98059
MEK
MAPK
12594.152
uM
inf
inf
 1.0136 1.0136 0.0000 -0.0365
-1.8606
 1.3085
MDA-MB-157
TNBC
Basal B
 PD173074
FGFR1/3
RTK
7496.093
uM
2.3160
5.92340
 -0.9320 -1.0000 1.1699 0.3311
0.9725
 0.9777
MDA-MB-157
TNBC
Basal B
 PD184352
MEK
MAPK
12594.155
uM
31.46540
33.07660
 0.4238 -0.1337 4.7444 0.0249
0.9749
 1.3872
MDA-MB-157
TNBC
Basal B
 PD184352
MEK
MAPK
12594.155
uM
31.46540
33.07660
 0.4238 -0.1337 4.7444 0.0249
0.9749
 1.3872
MDA-MB-157
TNBC
Basal B
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7496.095
uM
inf
inf
 0.3482 0.3482 0.0000 0.5830
0.0000
 1.0348
MDA-MB-157
TNBC
Basal B
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7498.095
uM
inf
inf
 0.8517 0.8517 0.0000 0.1552
0.3504
 1.2329
MDA-MB-157
TNBC
Basal B
 PS-1145
IKK
NFKB
7498.065
uM
inf
inf
 0.8341 0.8341 0.0000 0.0641
0.3368
 1.1827
MDA-MB-157
TNBC
Basal B
 PS-1145
IKK
NFKB
7496.065
uM
inf
1000.00000
 0.7525 0.5517 0.1406 0.1448
0.6582
 0.9526
MDA-MB-157
TNBC
Basal B
 PS-1145
IKK
NFKB
7495.065
uM
inf
34.4690
 0.8811 0.8987 4.9235 0.0218
0.8176
 1.2645
MDA-MB-157
TNBC
Basal B
 Purvalanol A
CDK1
CDK
7496.067
uM
inf
0.76541
 0.9048 0.9078 0.6376 0.0357
0.5769
 1.1301
MDA-MB-157
TNBC
Basal B
 Purvalanol A
CDK1
CDK
7498.067
uM
inf
284.49690
 0.8398 0.5893 0.8420 0.0128
0.7609
 1.1346
MDA-MB-157
TNBC
Basal B
 Purvalanol A
CDK1
CDK
7495.067
uM
inf
2.93990
 0.4899 0.5744 4.9993 0.1292
0.8928
 1.1275
MDA-MB-157
TNBC
Basal B
 QNZ
NFkB
NFKB
7496.096
uM
13.58150
999.76980
 0.3734 -0.7030 0.2042 0.2415
0.9391
 1.0771
MDA-MB-157
TNBC
Basal B
 Ribavirin
15321.211
uM
112.79660
23.45230
 0.5835 0.3561 0.7929 0.0700
0.9847
 2.7437
MDA-MB-157
TNBC
Basal B
 SB-3CT
MMP2/9
MMP
12594.168
uM
inf
22.51110
 0.8515 0.8506 2.5343 0.0205
0.7536
 1.2703