Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7498.091 | uM | 19.20760 | 26.21150 | -0.9722 | -0.9735 | 3.4764 | 0.4341 | 0.9980 | 1.1445 | |
| MDA-MB-157 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7496.067 | uM | 0.02684 | 0.03428 | -0.9834 | -0.5160 | 2.8953 | 0.7950 | 0.9351 | 1.1301 | |
| MDA-MB-157 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7495.067 | uM | 0.01568 | 0.02423 | -0.9958 | -0.5540 | 1.7154 | 0.8366 | 0.9375 | 1.1275 | |
| MDA-MB-157 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 7498.067 | uM | 0.02986 | 0.03823 | -0.9562 | -0.5429 | 2.9754 | 0.8002 | 0.9495 | 1.1346 | |
| MDA-MB-157 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7498.095 | uM | 0.00281 | 0.00750 | -0.9649 | -0.6387 | 0.8396 | 1.0591 | 0.9477 | 1.2329 | |
| MDA-MB-157 | TNBC | Basal B | Ixabepilone | TUBB | TUBB | 7496.095 | uM | 0.00644 | 0.01443 | -0.9956 | -0.7973 | 1.1830 | 1.0717 | 0.9856 | 1.0348 | |
| MDA-MB-157 | TNBC | Basal B | JNK-IN-5A | JNK | JNK | 12594.168 | uM | 139.96220 | 172.43870 | -0.3001 | -0.9193 | 4.9998 | 0.0684 | 0.9948 | 1.2703 | |
| MDA-MB-157 | TNBC | Basal B | L-779450 | BRAF | MAPK | 12594.166 | uM | 12.7230 | 26.42770 | -0.1730 | -1.0000 | 1.5029 | 0.1084 | 0.9879 | 1.0936 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7495.098 | uM | inf | inf | 0.8940 | 0.8940 | 0.0000 | 0.0304 | -0.0672 | 0.5841 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7496.098 | uM | 38.65430 | 20.79910 | 0.7518 | 0.3611 | 2.0670 | 0.0410 | 0.6276 | 0.9037 | |
| MDA-MB-157 | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7498.098 | uM | inf | 22.53420 | 0.8724 | 0.7240 | 0.6002 | 0.0132 | 0.6801 | 1.1057 | |
| MDA-MB-157 | TNBC | Basal B | LBH589 | HDAC | HDAC | 12594.167 | uM | 0.05661 | 0.16043 | -0.9295 | -0.9883 | 1.0470 | 0.8179 | 0.9918 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12594.167 | uM | 0.38176 | 1.83210 | -0.9527 | -1.0000 | 0.7004 | 0.4510 | 0.9495 | 1.4099 | |
| MDA-MB-157 | TNBC | Basal B | Mebendazole | 12632.174 | uM | 0.47426 | 1.51290 | -0.7326 | -0.7913 | 0.8179 | 0.5406 | 0.9867 | 0.8563 | |||
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7498.084 | uM | inf | 0.02401 | 0.5364 | 0.5217 | 1.7317 | 0.3634 | 0.9346 | 1.1749 | |
| MDA-MB-157 | TNBC | Basal B | Methotrexate | DHFR | Metabolism | 7496.085 | uM | 0.02709 | 0.02634 | 0.0403 | 0.0413 | 3.0536 | 0.7096 | 0.9894 | 1.0748 | |
| MDA-MB-157 | TNBC | Basal B | Methylglyoxal | 13611.184 | uM | 444.34060 | 663.74310 | -0.9810 | -0.8867 | 2.5419 | 0.7713 | 0.9453 | 0.8419 | |||
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14218.189 | uM | inf | inf | -0.3389 | -0.3389 | 0.0000 | 0.6358 | 0.5723 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14218.189 | uM | inf | inf | -0.3389 | -0.3389 | 0.0000 | 0.6358 | 0.5723 | 1.3111 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14931.189 | uM | 0.16304 | 0.18737 | -0.9980 | -0.5022 | 4.9995 | 0.8043 | 0.5910 | 0.6183 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 14931.189 | uM | 0.16304 | 0.18737 | -0.9980 | -0.5022 | 4.9995 | 0.8043 | 0.5910 | 0.6183 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 12594.17 | uM | 0.16250 | 0.26807 | -0.9603 | -0.9657 | 2.1485 | 0.8363 | 0.9991 | 1.2180 | |
| MDA-MB-157 | TNBC | Basal B | MG-132 | Proteasome | Proteasome | 12594.17 | uM | 0.16250 | 0.26807 | -0.9603 | -0.9657 | 2.1485 | 0.8363 | 0.9991 | 1.2180 | |
| MDA-MB-157 | TNBC | Basal B | Pevonedistat | NAE1 | NAE1 | 12594.135 | uM | 0.06018 | 0.13884 | -0.3682 | -0.3641 | 0.6544 | 0.6524 | 0.9873 | 1.3446 | |
| MDA-MB-157 | TNBC | Basal B | Nelfinavir | 12632.174 | uM | 8.66770 | 10.84610 | -0.9889 | -0.9971 | 4.8914 | 0.1686 | 0.9955 | 0.8563 |