Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-175-VII
HR+
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7500.095
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0333
-0.7066
 0.4619
MDA-MB-175-VII
HR+
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7499.094
uM
inf
inf
 1.0500 1.0500 0.0000 -0.0186
-0.2139
 0.6407
MDA-MB-175-VII
HR+
Luminal
 PS-1145
IKK
NFKB
7500.065
uM
inf
inf
 0.5879 0.5879 0.0000 0.1172
0.4159
 0.8201
MDA-MB-175-VII
HR+
Luminal
 PS-1145
IKK
NFKB
7499.065
uM
1031.61030
379.07370
 0.4575 0.2364 0.6394 0.1206
0.8825
 0.5419
MDA-MB-175-VII
HR+
Luminal
 Purvalanol A
CDK1
CDK
7500.067
uM
inf
inf
 1.0382 1.0382 0.0000 0.0025
-0.0022
 0.7143
MDA-MB-175-VII
HR+
Luminal
 Purvalanol A
CDK1
CDK
7499.067
uM
37.86630
75.95080
 -0.3196 -0.7766 1.3468 0.2197
0.9415
 0.7759
MDA-MB-175-VII
HR+
Luminal
 Ro 32-0432
PKC
PKC
10642.142
uM
inf
inf
 0.8827 0.8827 0.0000 0.0460
0.1393
 0.5006
MDA-MB-175-VII
HR+
Luminal
 SB-3CT
MMP2/9
MMP
10642.144
uM
inf
inf
 0.7684 0.7684 0.0000 0.1437
0.1354
 0.6510
MDA-MB-175-VII
HR+
Luminal
 SB-3CT
MMP2/9
MMP
10818.144
uM
inf
inf
 0.8824 0.8824 0.0000 0.1129
0.2209
 0.4912
MDA-MB-175-VII
HR+
Luminal
 SB-3CT
MMP2/9
MMP
12126.144
uM
inf
inf
 0.4468 0.4468 0.0000 0.2552
0.5580
 0.6379
MDA-MB-175-VII
HR+
Luminal
 Selumetinib
MEK
MAPK
10818.155
uM
0.78888
21.95960
 -0.2195 -1.0000 0.3303 0.4053
0.9434
 0.6048
MDA-MB-175-VII
HR+
Luminal
 Selumetinib
MEK
MAPK
12126.155
uM
1.72880
64.9050
 0.0200 -1.0000 0.3030 0.3394
0.9450
 0.6799
MDA-MB-175-VII
HR+
Luminal
 Selumetinib
MEK
MAPK
10642.146
uM
2.78820
8.90830
 -0.3119 -0.6697 0.7317 0.2582
0.9895
 0.7272
MDA-MB-175-VII
HR+
Luminal
 Sigma A6730
AKT
AKT
10818.153
uM
1.31410
4.28860
 -0.9481 -1.0000 0.9288 0.5228
0.9568
 0.6469
MDA-MB-175-VII
HR+
Luminal
 Sigma A6730
AKT
AKT
12126.158
uM
3.8660
6.45820
 -0.9977 -1.0000 2.1410 0.4046
0.9755
 0.5992
MDA-MB-175-VII
HR+
Luminal
 Sigma A6730
AKT
AKT
10642.141
uM
1.68880
3.46820
 -0.9963 -1.0000 1.5267 0.5003
0.9904
 0.4059
MDA-MB-175-VII
HR+
Luminal
 Sirolimus
MTOR
MTOR
7499.068
uM
0.00340
0.00322
 -0.0222 0.0221 0.8180 0.8082
0.9641
 0.7825
MDA-MB-175-VII
HR+
Luminal
 Sirolimus
MTOR
MTOR
7500.069
uM
0.00293
0.00185
 0.3935 0.4499 4.9999 0.4145
0.9762
 0.7701
MDA-MB-175-VII
HR+
Luminal
 Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
7499.084
uM
7.87410
8.66330
 -0.7584 -0.3061 5.0000 0.5234
0.7548
 0.7991
MDA-MB-175-VII
HR+
Luminal
 Sorafenib
PDGFR/VEGFR/KIT/FLT3
RTK
7500.084
uM
106.2680
117.60260
 -0.3263 -0.3299 5.0000 0.2265
0.9836
 0.5811
MDA-MB-175-VII
HR+
Luminal
 Sulindac sulfide
COX1/2
COX
10642.136
uM
inf
inf
 0.4161 0.4161 0.0000 0.2309
0.5461
 0.5193
MDA-MB-175-VII
HR+
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7499.067
uM
5.72070
8.77250
 -0.9999 -1.0000 2.5696 0.5490
0.9696
 0.7759
MDA-MB-175-VII
HR+
Luminal
 Sunitinib
PDGFR/VEGFR/KIT/FLT3
RTK
7500.067
uM
8.01910
9.98970
 -0.9996 -1.0000 4.9998 0.4013
0.9914
 0.7143
MDA-MB-175-VII
HR+
Luminal
 Taxol
TUBB
TUBB
7885.002
uM
0.02039
0.01063
 0.1764 0.2596 1.1247 0.4687
0.9672
 0.7110
MDA-MB-175-VII
HR+
Luminal
 Taxol
TUBB
TUBB
7886.002
uM
0.01382
0.01129
 0.2562 0.3187 5.0000 0.4089
0.9786
 0.7173