Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7507.098 | uM | 12.0880 | 18.40370 | -0.9532 | -1.0000 | 2.6136 | 0.2583 | 0.9872 | 1.0164 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7508.071 | uM | 5.49120 | 6.97350 | -0.9903 | -0.9921 | 4.5752 | 0.4743 | 0.9876 | 0.8372 | |
| MDA-MB-361 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 7507.07 | uM | 14.20950 | 20.63080 | -0.9449 | -1.0000 | 2.9463 | 0.1923 | 0.9946 | 1.0062 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 10095.001 | uM | 0.01185 | 0.56078 | -0.9427 | -1.0000 | 0.2848 | 0.7053 | 0.7348 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7894.001 | uM | 0.00171 | 0.00176 | -0.2941 | -0.0655 | 5.0000 | 0.8182 | 0.9150 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7896.001 | uM | 0.00127 | 0.00125 | -0.1757 | 0.0463 | 5.0000 | 0.7450 | 0.9286 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9648.001 | uM | 0.01611 | 0.01774 | -0.4274 | -0.3105 | 5.0000 | 0.7474 | 0.9916 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 10095.001 | uM | 0.02234 | 0.02379 | -0.1877 | -0.1848 | 5.0000 | 0.6926 | 0.9889 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7894.001 | uM | 0.03219 | 0.03531 | -0.3372 | -0.2936 | 5.0000 | 0.6871 | 0.9910 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7896.001 | uM | 0.05334 | 0.05671 | -0.2061 | -0.1787 | 4.9997 | 0.5695 | 0.9949 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9648.001 | uM | 0.03038 | 0.03448 | -0.5309 | -0.4420 | 5.0000 | 0.7858 | 0.9966 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 7506.088 | uM | inf | inf | 0.9523 | 0.9523 | 0.0000 | 0.0495 | 0.3355 | 1.0417 | |
| MDA-MB-361 | HER2amp | Luminal | GW843682X | PLK | PLK | 10643.139 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | Ibandronate | FDPS | 10643.143 | uM | 6.54950 | 16.83150 | -0.9554 | -0.9755 | 1.1465 | 0.7291 | 0.9827 | 0.4866 | ||
| MDA-MB-361 | HER2amp | Luminal | Ibandronate | FDPS | 12379.143 | uM | 20.92490 | 37.63950 | -0.9452 | -0.9364 | 1.7974 | 0.5781 | 0.9924 | 0.4493 | ||
| MDA-MB-361 | HER2amp | Luminal | Ibandronate | FDPS | 10999.143 | uM | 13.74950 | 25.12820 | -0.9477 | -0.9313 | 1.7442 | 0.5961 | 0.9979 | 0.5216 | ||
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10999.151 | uM | inf | inf | 0.6771 | 0.6771 | 0.0000 | 0.0774 | 0.0387 | 0.7090 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 10643.139 | uM | inf | 1.44440 | 0.7444 | 0.7596 | 5.0000 | 0.0465 | 0.7569 | 0.6402 | |
| MDA-MB-361 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12379.157 | uM | 19.94190 | 15.33540 | 0.3618 | 0.3598 | 4.8411 | 0.0082 | 0.9579 | 0.4910 | |
| MDA-MB-361 | HER2amp | Luminal | IKK16 | IKK | NFKB | 10472.1 | uM | 3.2240 | 4.01630 | -0.9992 | -0.9997 | 4.9985 | 0.4098 | 0.9892 | 0.6324 | |
| MDA-MB-361 | HER2amp | Luminal | IKK16 | IKK | NFKB | 7506.093 | uM | 5.21240 | 6.49330 | -0.9868 | -1.0000 | 4.9995 | 0.3330 | 0.9968 | 0.9162 | |
| MDA-MB-361 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7505.09 | uM | inf | 6.12490 | 0.4003 | 0.5904 | 5.0000 | 0.1614 | 0.6629 | 0.6295 | |
| MDA-MB-361 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7506.091 | uM | 24.27730 | 34.49490 | -0.9722 | -0.9825 | 3.0942 | 0.4789 | 0.9863 | 1.1096 | |
| MDA-MB-361 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7508.091 | uM | 23.25790 | 30.52730 | -0.9990 | -1.0000 | 4.0394 | 0.4722 | 0.9925 | 0.6662 | |
| MDA-MB-361 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7507.09 | uM | 26.30030 | 34.26880 | -0.9817 | -0.9818 | 4.1049 | 0.3888 | 0.9989 | 1.0118 |