Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 9664.001 | uM | 0.46551 | 3.51420 | -0.9395 | -1.0000 | 0.5435 | 0.4700 | 0.8529 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK1070916 | AURK | AURK | 7897.001 | uM | 0.43180 | 2.98110 | -0.9778 | -1.0000 | 0.5686 | 0.5033 | 0.8695 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7510.09 | uM | 20.38630 | 999.96150 | 0.3151 | -0.6964 | 0.2241 | 0.2668 | 0.7519 | 1.0960 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7512.091 | uM | 30.9970 | 46.80270 | -0.9135 | -1.0000 | 2.6662 | 0.3123 | 0.7992 | 0.8817 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7511.098 | uM | 4.71530 | 31.68110 | -0.3683 | -1.0000 | 0.5767 | 0.2849 | 0.9060 | 1.2032 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7512.098 | uM | 51.29850 | 0.36196 | 0.4706 | 0.4446 | 0.4442 | 0.2308 | 0.9392 | 0.9499 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7511.091 | uM | 2.20830 | 5.82940 | -0.9411 | -1.0000 | 1.1318 | 0.5657 | 0.9578 | 1.0995 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7512.071 | uM | 5.11320 | 7.40540 | -0.9707 | -0.9900 | 2.9481 | 0.5078 | 0.9682 | 0.9528 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7510.098 | uM | 3.35320 | 4.1420 | -0.9397 | -0.9378 | 5.0000 | 0.4615 | 0.9685 | 0.9528 | |
| MDA-MB-415 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 7510.07 | uM | 3.36530 | 4.18420 | -0.9830 | -0.9849 | 4.9980 | 0.4538 | 0.9857 | 0.8102 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9664.001 | uM | 0.02475 | 0.91113 | -0.9937 | -1.0000 | 0.3047 | 0.6427 | 0.6673 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 7897.001 | uM | 0.03014 | 0.90795 | -0.9955 | -1.0000 | 0.3226 | 0.6392 | 0.7320 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 7897.001 | uM | 0.04258 | 0.76193 | -0.8674 | -1.0000 | 0.3809 | 0.6445 | 0.8560 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9664.001 | uM | 0.09058 | 0.11743 | -0.6996 | -0.2760 | 1.6935 | 0.5290 | 0.9019 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | Ibandronate | FDPS | 12333.143 | uM | 48.64890 | 54.3240 | -0.4546 | -0.3681 | 4.9998 | 0.4351 | 0.9371 | 0.6265 | ||
| MDA-MB-415 | HR+ | Luminal | Ibandronate | FDPS | 10938.143 | uM | 46.92680 | 98.68990 | -0.8792 | -0.9200 | 1.4041 | 0.4882 | 0.9554 | 1.0173 | ||
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10938.151 | uM | inf | inf | 0.3561 | 0.3561 | 0.0000 | 0.2452 | 0.2832 | 1.0747 | |
| MDA-MB-415 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12333.157 | uM | 1.11480 | 997.78850 | 0.1558 | -0.7896 | 0.1394 | 0.3966 | 0.8546 | 0.7591 | |
| MDA-MB-415 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7510.09 | uM | 21.41730 | 26.6730 | -0.9982 | -0.9975 | 4.9986 | 0.5138 | 0.9782 | 1.0960 | |
| MDA-MB-415 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7511.091 | uM | 20.21780 | 30.49470 | -0.9964 | -1.0000 | 2.6731 | 0.5022 | 0.9870 | 1.0995 | |
| MDA-MB-415 | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7512.091 | uM | 22.97740 | 29.06070 | -0.9947 | -0.9904 | 4.6502 | 0.4180 | 0.9986 | 0.8817 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7510.067 | uM | 0.06803 | 0.70047 | -0.9998 | -1.0000 | 0.4711 | 0.6174 | 0.9124 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7511.067 | uM | 0.10835 | 0.82269 | -0.9948 | -1.0000 | 0.5419 | 0.6145 | 0.9158 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 7512.067 | uM | 0.04965 | 0.42081 | -0.9947 | -1.0000 | 0.5140 | 0.7007 | 0.9193 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Ixabepilone | TUBB | TUBB | 7510.094 | uM | inf | inf | -0.4981 | -0.4981 | 0.0000 | 0.7601 | 0.3729 | 0.8152 |