GSK1838705A - Small Molecule (ID:10255-101)

HMS LINCS ID: 10255-101
Name: GSK1838705A
Alternative Names:
LINCS ID: LSM-4276
PubChem CID: 25182616
ChEBI ID:
ChEMBL ID:
Molecular Mass: 532.23
InChi: InChI=1S/C27H29FN8O3/c1-29-26(38)23-17(28)6-5-7-18(23)31-25-16-8-10-30-24(16)33-27(34-25)32-19-13-20-15(12-21(19)39-4)9-11-36(20)22(37)14-35(2)3/h5-8,10,12-13H,9,11,14H2,1-4H3,(H,29,38)(H3,30,31,32,33,34)
InChi Key: HZTYDQRUAWIZRE-UHFFFAOYSA-N
SMILES: CNC(=O)C1=C(C=CC=C1F)NC2=NC(=NC3=C2C=CN3)NC4=C(C=C5CCN(C5=C4)C(=O)CN(C)C)OC
Relevant Citations:
Comments:
Date Publicly Available:
Most Recent Update: 2016-05-06

Target Affinity:

(see Study 20000)
Target Affinity Spectrum Value HUGO Gene Name
1
(Kd <100 nM)
ALK, CLK1, CLK2, CLK4, FER, FES, IGF1R, INSR, INSRR, LTK, MYLK, PLK1, PTK2B, ROS1, STK33, TTK
2
(equivalent to 100 nM ≤ Kd < 1µM)
AXL, CAMK4, CHEK2, CSNK1E, DAPK1, DYRK1B, GAK, GRK1, GRK7, LRRK2, MAP2K4, MAP3K19, MAPK10, MAPK8, MAPK9, PKD1, PRKD1, PRKD3, PTK2, RPS6KA1, RPS6KA3, TPTEP2-CSNK1E, TSSK1B
3
(equivalent to 1µM ≤ Kd < 10 µM)
CSNK1D, CSNK2A1, DAPK2, DAPK3, DCLK1, DSTYK, DYRK1A, EGFR, ERBB4, FLT3, HIPK1, HIPK2, HIPK3, HIPK4, IRAK1, JAK2, JAK3, MAP2K3, MAP3K7, MERTK, OSR1, OXSR1, PHKG1, PHKG2, RIOK2, RPS6KA2, RPS6KA6, STK16, TAOK1, TAOK3, TNK1
10
(confirmed non-binding)
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Batch Information for HMSL10255-101-1:

HMS LINCS Batch ID: 10255-101-1
Provider: GlaxoSmithKline
Provider Batch ID:
Salt: 101
Molecular Formula:
Molecular Weight:
Purity:
Purification Method:
Chemical Synthesis Reference:
Comments:
Date Publicly Available: 2012-11-14
Most Recent Update: 2016-12-02