Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7518.074 | uM | 0.05301 | 0.09286 | -0.6120 | -0.5370 | 1.3013 | 0.8933 | 0.9891 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7518.074 | uM | 0.05301 | 0.09286 | -0.6120 | -0.5370 | 1.3013 | 0.8933 | 0.9891 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7517.074 | uM | 0.03615 | 0.08652 | -0.6508 | -0.6252 | 0.9294 | 0.9571 | 0.9956 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Bortezomib | Proteasome | Proteasome | 7517.074 | uM | 0.03615 | 0.08652 | -0.6508 | -0.6252 | 0.9294 | 0.9571 | 0.9956 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Bosutinib | Src | nRTK | 12414.17 | uM | 2.32520 | 2.51780 | -0.2891 | -0.2444 | 5.0000 | 0.2666 | 0.9896 | 1.2052 | |
| MDA-MB-453 | TNBC | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 12964.177 | uM | 0.06663 | 0.16807 | -0.9991 | -1.0000 | 1.1874 | 0.8784 | 0.9754 | 0.7495 | |
| MDA-MB-453 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 7903.011 | uM | 48.29010 | 91.330 | -0.8746 | -0.8921 | 1.6069 | 0.4130 | 0.9957 | 1.1535 | |
| MDA-MB-453 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9723.12 | uM | 58.35370 | 102.74960 | -0.8939 | -0.9029 | 1.8235 | 0.3435 | 0.9960 | 0.8437 | |
| MDA-MB-453 | TNBC | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9708.011 | uM | 57.54030 | 82.18660 | -0.6731 | -0.6680 | 2.3798 | 0.3383 | 0.9965 | 1.0535 | |
| MDA-MB-453 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 9723.124 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0369 | -1.9688 | 0.9827 | |
| MDA-MB-453 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 9708.006 | uM | inf | inf | 0.3920 | 0.3920 | 0.0000 | 0.4384 | -0.2523 | 0.6313 | |
| MDA-MB-453 | TNBC | Luminal | Cetuximab | EGFR | ErbB | 7903.042 | uM | inf | inf | 0.9956 | 0.9956 | 0.0000 | -0.0024 | -0.0113 | 1.1508 | |
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 9708.006 | uM | 0.96723 | 0.97368 | -0.5364 | -0.0169 | 5.0000 | 0.6836 | 0.6648 | 0.6313 | ||
| MDA-MB-453 | TNBC | Luminal | CGC-11047 | Polyamine analogue | 9723.124 | uM | inf | 0.07331 | 0.4338 | 0.5359 | 3.4322 | 0.3131 | 0.9350 | 0.9827 | ||
| MDA-MB-453 | TNBC | Luminal | Chloroquine | 12964.177 | uM | 1.44290 | 4.19660 | -0.9958 | -1.0000 | 1.0290 | 0.5575 | 0.9273 | 0.7495 | |||
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9723.049 | uM | inf | inf | 1.0150 | 1.0150 | 0.0000 | -0.0107 | -0.0715 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9708.017 | uM | 6.93290 | 12.75960 | -0.8130 | -0.8473 | 1.6250 | 0.4231 | 0.9976 | 1.0949 | |
| MDA-MB-453 | TNBC | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 7903.017 | uM | 7.3740 | 15.69730 | -0.9454 | -0.9920 | 1.4470 | 0.4212 | 0.9981 | 1.1625 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 10270.121 | uM | 3.07860 | 11.60770 | -0.7011 | -1.0000 | 0.8278 | 0.3445 | 0.9915 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 9723.121 | uM | 6.76050 | 19.06660 | -0.5324 | -0.8802 | 0.9793 | 0.2210 | 0.9918 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | CPT-11 | TOP1 | TOP | 9708.121 | uM | 6.37030 | 9.02180 | -0.4928 | -0.5090 | 2.0174 | 0.2565 | 0.9957 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Dactolisib | PI3K | PI3K | 12414.155 | uM | 0.08844 | 0.10838 | -0.4719 | -0.4908 | 3.3629 | 0.7050 | 0.9878 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Dichloroacetate | PDK | PDK | 12964.176 | uM | inf | inf | 0.7414 | 0.7414 | 0.0000 | 0.1261 | 0.5198 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Dichloroacetate | PDK | PDK | 13562.176 | uM | inf | 332.99730 | 0.6913 | -0.3047 | 0.2920 | 0.0735 | 0.6257 | 0.8217 | |
| MDA-MB-453 | TNBC | Luminal | Disulfiram | Proteasome | Proteasome | 12964.174 | uM | 0.08506 | 0.08039 | -0.0544 | 0.1230 | 5.0000 | 0.5012 | 0.8196 | 0.7885 |