Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Disulfiram | Proteasome | Proteasome | 13562.174 | uM | 0.04263 | 0.04221 | 0.1809 | 0.0240 | 4.9989 | 0.5519 | 0.8768 | 0.7219 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9723.002 | uM | 0.01285 | 0.01435 | -0.3187 | -0.3679 | 5.0000 | 0.6997 | 0.9830 | 0.8443 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 12964.002 | uM | 0.00508 | 0.00854 | -0.5878 | -0.4796 | 1.2915 | 0.8145 | 0.990 | 0.5925 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 9708.002 | uM | 0.00410 | 0.00517 | -0.2719 | -0.2112 | 1.5193 | 0.7165 | 0.9926 | 1.0482 | |
| MDA-MB-453 | TNBC | Luminal | Docetaxel | TUBB | TUBB | 7903.002 | uM | 0.00363 | 0.00472 | -0.4272 | -0.4291 | 2.3694 | 0.8593 | 0.9957 | 1.2202 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 10270.121 | uM | inf | inf | -0.0977 | -0.0977 | 0.0000 | 0.6609 | 0.4250 | 0.8235 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 9708.121 | uM | 0.18334 | 0.25399 | -0.9966 | -0.8676 | 3.0870 | 0.8315 | 0.9948 | 1.1394 | |
| MDA-MB-453 | TNBC | Luminal | Doxorubicin | TOP2 | TOP | 9723.121 | uM | 0.22157 | 0.32961 | -0.9910 | -0.9066 | 2.6041 | 0.8287 | 0.9948 | 0.9445 | |
| MDA-MB-453 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 9708.017 | uM | 0.19697 | 0.41153 | -0.9990 | -0.9299 | 1.4260 | 0.8962 | 0.9973 | 1.0949 | |
| MDA-MB-453 | TNBC | Luminal | Epirubicin | TOP2 | TOP | 7903.017 | uM | 0.25987 | 0.42288 | -0.9984 | -0.9686 | 2.2128 | 0.9192 | 0.9996 | 1.1625 | |
| MDA-MB-453 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 7517.091 | uM | inf | inf | 0.4989 | 0.4989 | 0.0000 | 0.1689 | 0.2697 | 1.5552 | |
| MDA-MB-453 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 7515.092 | uM | inf | inf | 0.4666 | 0.4666 | 0.0000 | 0.1777 | 0.2780 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 7516.092 | uM | 45.48620 | 57.3540 | 0.6762 | -0.3014 | 2.0346 | 0.0398 | 0.7135 | 1.1035 | |
| MDA-MB-453 | TNBC | Luminal | Erlotinib | EGFR | ErbB | 7518.091 | uM | 116.66380 | 835.74150 | 0.5968 | -1.0000 | 0.5580 | 0.0818 | 0.8677 | 1.6174 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 7518.074 | uM | 5.99190 | 15.47920 | 0.0169 | -0.2714 | 0.4568 | 0.3652 | 0.9708 | 1.6204 | |
| MDA-MB-453 | TNBC | Luminal | Etoposide | TOP2 | TOP | 7517.074 | uM | 4.93150 | 9.22330 | -0.1234 | -0.2509 | 0.6495 | 0.3887 | 0.9779 | 1.5337 | |
| MDA-MB-453 | TNBC | Luminal | Everolimus | MTOR | MTOR | 12414.164 | uM | 0.02522 | 0.03069 | -0.6931 | -0.1910 | 1.6472 | 0.6877 | 0.8707 | 1.2548 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 7518.084 | uM | 0.11063 | 0.25363 | -0.9355 | -0.9945 | 1.3197 | 0.7672 | 0.9923 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Fascaplysin | CDK4 | CDK | 7517.084 | uM | 0.08869 | 0.20861 | -0.9680 | -1.0000 | 1.2844 | 0.8235 | 0.9932 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | FR180204 | ERK1/2 | MAPK | 12414.166 | uM | inf | inf | 0.7012 | 0.7012 | 0.0000 | 0.1209 | 0.3913 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | FTase Inhibitor I | Ftase | MAPK | 12414.167 | uM | inf | 991.53220 | 0.8151 | 0.2157 | 0.4515 | 0.0425 | 0.6815 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 9723.049 | uM | 8.05810 | 8.54910 | -0.1705 | -0.1718 | 4.9926 | 0.0675 | 0.9878 | 0.9525 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 9708.019 | uM | 7.16790 | 7.86460 | -0.2928 | -0.2937 | 4.9821 | 0.1080 | 0.9932 | 1.1580 | |
| MDA-MB-453 | TNBC | Luminal | Gefitinib | EGFR | ErbB | 7903.016 | uM | 6.5570 | 8.06510 | -0.8145 | -0.8169 | 4.6781 | 0.1708 | 0.9963 | 1.1196 | |
| MDA-MB-453 | TNBC | Luminal | Geldanamycin | HSP90 | HSP90 | 9708.012 | uM | 0.00682 | 0.00786 | -0.5552 | -0.5153 | 4.9993 | 1.0967 | 0.9854 | 0.9799 |