Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-468
TNBC
Basal A
 Vinorelbine
TUBB
TUBB
7905.018
uM
0.00355
0.00425
 -0.8287 -0.7200 5.0000 1.2755
0.9033
 0.8988
MDA-MB-468
TNBC
Basal A
 Vinorelbine
TUBB
TUBB
7907.018
uM
0.00547
0.00613
 -0.5052 -0.3801 4.9982 0.9722
0.9248
 1.5217
MDA-MB-468
TNBC
Basal A
 Vinorelbine
TUBB
TUBB
7904.018
uM
0.00689
0.00750
 -0.4819 -0.2650 5.0000 0.8507
0.9635
 1.4056
MX1
Unknown
Unknown
 2-deoxyglucose
12667.177
uM
11.79570
227.13510
 -0.8185 -1.0000 0.3714 0.5703
0.5880
 0.5892
MX1
Unknown
Unknown
 5-DFUR
TYMS
TYMS
12220.143
uM
inf
inf
 -0.8023 -0.8023 0.0000 0.8282
0.4044
 0.4532
MX1
Unknown
Unknown
 5-DFUR
TYMS
TYMS
10644.143
uM
30.49630
1000.00000
 -0.6190 -0.9111 0.2973 0.4566
0.6009
 0.6221
MX1
Unknown
Unknown
 5-DFUR
TYMS
TYMS
10874.143
uM
767.35840
1000.00000
 -0.3025 -0.2570 1.5664 0.2339
0.7658
 0.7639
MX1
Unknown
Unknown
 Afatinib
EGFR/HER2
ErbB
12220.158
uM
0.17826
0.56481
 -0.9999 -1.0000 0.9526 0.7567
0.9683
 0.4308
MX1
Unknown
Unknown
 AG1024
IGF1R
RTK
7523.066
uM
47.97040
999.92680
 0.5009 -0.8438 0.3255 0.1405
0.8413
 0.8127
MX1
Unknown
Unknown
 AS-252424
PI3K
PI3K
10874.153
uM
inf
inf
 0.8891 0.8891 0.0000 0.0941
0.0211
 0.8467
MX1
Unknown
Unknown
 AS-252424
PI3K
PI3K
12220.158
uM
inf
inf
 -0.2937 -0.2937 0.0000 0.1457
0.3428
 0.4308
MX1
Unknown
Unknown
 AS-252424
PI3K
PI3K
10644.141
uM
6.57020
10.16520
 -0.9764 -0.9942 2.5084 0.3274
0.9875
 0.4530
MX1
Unknown
Unknown
 Baicalein
Lipoxygenase
Metabolism
10644.072
uM
11.9330
20.2750
 -0.9342 -0.9645 2.0273 0.3974
0.9668
 0.5146
MX1
Unknown
Unknown
 Baicalein
Lipoxygenase
Metabolism
10874.072
uM
32.26710
52.66490
 -0.8891 -1.0000 2.2425 0.2194
0.9784
 0.8811
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14918.203
uM
0.00872
0.01466
 -0.9994 -0.9980 2.1115 1.3233
0.9984
 0.5296
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
14918.203
uM
0.00872
0.01466
 -0.9994 -0.9980 2.1115 1.3233
0.9984
 0.5296
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7523.074
uM
0.03191
0.04423
 -0.9955 -0.9938 3.3537 1.2965
0.9990
 0.8505
MX1
Unknown
Unknown
 Bortezomib
Proteasome
Proteasome
7523.074
uM
0.03191
0.04423
 -0.9955 -0.9938 3.3537 1.2965
0.9990
 0.8505
MX1
Unknown
Unknown
 Bosutinib
Src
nRTK
10874.145
uM
1.43740
5.69250
 -0.6805 -0.9193 0.7581 0.4423
0.9637
 0.8505
MX1
Unknown
Unknown
 Bosutinib
Src
nRTK
10644.145
uM
0.45499
0.69131
 -0.9999 -0.9024 2.4654 0.7369
0.9830
 0.4300
MX1
Unknown
Unknown
 Bromopyruvic acid
Hexokinase II
Metabolism
12667.177
uM
0.02030
0.02529
 -1.0000 -1.0000 5.0000 1.1110
0.9986
 0.5892
MX1
Unknown
Unknown
 Celecoxib
COX2
COX
10644.136
uM
23.48360
26.10660
 -0.9077 -0.3445 4.9495 0.3623
0.7525
 0.5562
MX1
Unknown
Unknown
 Chk2 inhibitor II
CHK2
CHK
10644.14
uM
23.6950
28.24010
 -0.5217 -0.5598 4.2810 0.0980
0.9881
 0.4302
MX1
Unknown
Unknown
 Chloroquine
12667.177
uM
5.25790
8.90730
 -0.9240 -0.9590 2.0316 0.4375
0.7869
 0.5892
MX1
Unknown
Unknown
 Dactolisib
PI3K
PI3K
10644.146
uM
inf
inf
 0.1541 0.1541 0.0000 0.1802
0.4897
 0.5967