Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

 Full screen view
Filter results: >>>>
Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
SK-BR-3
HER2amp
Luminal
 Methylglyoxal
13615.184
uM
inf
inf
 -0.4094 -0.4094 0.0000 0.5413
0.5486
 1.1889
SK-BR-3
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
14221.189
uM
0.38888
0.42642
 -0.2311 -0.2926 5.0000 0.5659
0.9124
 1.5537
SK-BR-3
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
14221.189
uM
0.38888
0.42642
 -0.2311 -0.2926 5.0000 0.5659
0.9124
 1.5537
SK-BR-3
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
11851.145
uM
0.23297
0.33237
 -0.7591 -0.7396 2.5550 0.7311
0.9970
 1.4873
SK-BR-3
HER2amp
Luminal
 MG-132
Proteasome
Proteasome
11851.145
uM
0.23297
0.33237
 -0.7591 -0.7396 2.5550 0.7311
0.9970
 1.4873
SK-BR-3
HER2amp
Luminal
 Pevonedistat
NAE1
NAE1
11851.135
uM
0.14156
0.11342
 0.0405 0.0900 0.8958 0.4659
0.9746
 1.2721
SK-BR-3
HER2amp
Luminal
 Nelfinavir
12999.174
uM
7.55250
13.51060
 -0.7021 -1.0000 1.8890 0.2038
0.9850
 0.8315
SK-BR-3
HER2amp
Luminal
 Nilotinib
ABL
nRTK
11851.145
uM
inf
inf
 1.0500 1.0500 0.0000 0.0487
0.0000
 1.4873
SK-BR-3
HER2amp
Luminal
 NSC 663284
CDC25
CDC
11851.159
uM
1.39190
2.24970
 -0.9542 -0.9582 2.2292 0.6704
0.9966
 1.2582
SK-BR-3
HER2amp
Luminal
 NU6102
CDK1/2
CDK
11851.147
uM
32.73820
244.92960
 0.3081 -1.0000 0.5459 0.1356
0.9337
 1.4004
SK-BR-3
HER2amp
Luminal
 Nutlin 3a
MDM2
MDM2
7526.066
uM
62.51910
144.02380
 0.4665 -0.9981 1.3149 0.0502
0.9610
 1.5937
SK-BR-3
HER2amp
Luminal
 Nutlin 3a
MDM2
MDM2
7527.066
uM
42.99420
100.44010
 0.2596 -0.9939 1.2900 0.0727
0.9895
 1.9970
SK-BR-3
HER2amp
Luminal
 Olomoucine II
CDK1
CDK
11851.147
uM
9.42480
12.15250
 -0.6584 -0.6592 3.3080 0.3078
0.9974
 1.4004
SK-BR-3
HER2amp
Luminal
 Omipalisib
PI3K
PI3K
7527.086
uM
0.00439
0.00455
 -0.0326 -0.0168 0.9467 0.7017
0.9985
 1.6742
SK-BR-3
HER2amp
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
10127.12
uM
1.20380
3.08350
 -1.0000 -1.0000 1.1680 0.8668
0.9845
 0.5076
SK-BR-3
HER2amp
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9760.011
uM
3.67870
8.71380
 -0.9814 -0.9978 1.2723 0.6704
0.9945
 0.9634
SK-BR-3
HER2amp
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9759.011
uM
2.11420
6.14970
 -0.9000 -0.9121 0.9724 0.6810
0.9991
 1.2153
SK-BR-3
HER2amp
Luminal
 Oxamflatin
HDAC
HDAC
11851.147
uM
1.29190
2.87870
 -0.9041 -0.9912 1.3639 0.5193
0.9926
 1.4004
SK-BR-3
HER2amp
Luminal
 PD 98059
MEK
MAPK
11851.159
uM
22.230
21.36230
 0.2400 0.0160 0.8146 0.1793
0.9354
 1.2582
SK-BR-3
HER2amp
Luminal
 PD173074
FGFR1/3
RTK
7527.093
uM
10.3490
20.51830
 -0.3706 -1.0000 1.6051 0.1393
0.9942
 1.8070
SK-BR-3
HER2amp
Luminal
 PD184352
MEK
MAPK
11851.155
uM
inf
inf
 0.8385 0.8385 0.0000 0.1181
-0.3292
 1.5585
SK-BR-3
HER2amp
Luminal
 PD184352
MEK
MAPK
11851.155
uM
inf
inf
 0.8385 0.8385 0.0000 0.1181
-0.3292
 1.5585
SK-BR-3
HER2amp
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7526.095
uM
0.03658
0.01535
 0.3965 0.3746 1.5922 0.5872
0.8874
 1.4693
SK-BR-3
HER2amp
Luminal
 Pemetrexed
TYMS/DHFR/GARFT
TYMS
7527.095
uM
inf
0.13260
 0.6424 0.6761 1.1379 0.2553
0.9126
 1.9173
SK-BR-3
HER2amp
Luminal
 PS-1145
IKK
NFKB
7526.065
uM
inf
inf
 0.9526 0.9526 0.0000 0.1058
0.0133
 1.5585