Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7527.065 | uM | inf | inf | 0.9271 | 0.9271 | 0.0000 | 0.0447 | 0.40 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7527.067 | uM | inf | inf | 0.9639 | 0.9639 | 0.0000 | 0.0101 | 0.4774 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7526.067 | uM | 25.30920 | 20.59210 | 0.2084 | 0.2047 | 2.5537 | 0.1370 | 0.9925 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | QNZ | NFkB | NFKB | 7527.096 | uM | 0.86756 | 0.06272 | 0.4117 | 0.4016 | 0.6187 | 0.2932 | 0.9813 | 2.1119 | |
| SK-BR-3 | HER2amp | Luminal | Ribavirin | 15356.211 | uM | 56.09170 | 112.68280 | 0.5457 | -0.6405 | 1.1821 | 0.0574 | 0.8733 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 11851.144 | uM | inf | inf | 0.6379 | 0.6379 | 0.0000 | 0.1178 | 0.3811 | 1.3716 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 11851.155 | uM | inf | inf | 0.9361 | 0.9361 | 0.0000 | 0.0510 | 0.0449 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 11851.158 | uM | 2.15850 | 5.82470 | -0.4000 | -0.6118 | 0.8050 | 0.3418 | 0.9961 | 1.4217 | |
| SK-BR-3 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7914.068 | uM | 0.06865 | 18.55130 | -0.3399 | -1.0000 | 0.1962 | 0.6492 | 0.8399 | 1.2509 | |
| SK-BR-3 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7912.068 | uM | 0.00112 | 0.00189 | -0.4187 | -0.3319 | 0.9812 | 1.1470 | 0.9516 | 0.5196 | |
| SK-BR-3 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7526.069 | uM | 0.07367 | 0.01750 | 0.3623 | 0.4071 | 1.1712 | 0.3470 | 0.9809 | 1.4532 | |
| SK-BR-3 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7527.085 | uM | inf | inf | 0.6561 | 0.6561 | 0.0000 | 0.0637 | 0.1476 | 1.9392 | |
| SK-BR-3 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7526.084 | uM | 173.86930 | 58.4190 | 0.4187 | 0.1339 | 0.2857 | 0.2738 | 0.8246 | 1.8115 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7526.067 | uM | 7.19190 | 10.41620 | -0.8826 | -0.8919 | 2.7640 | 0.4343 | 0.9945 | 1.8189 | |
| SK-BR-3 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7527.067 | uM | 7.2360 | 10.17670 | -0.8758 | -0.8812 | 2.9796 | 0.4111 | 0.9983 | 1.9179 | |
| SK-BR-3 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 7527.096 | uM | inf | 198.72450 | 0.8318 | 0.5381 | 0.2430 | 0.0719 | 0.6490 | 2.1119 | ||
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10127.002 | uM | 0.00852 | 0.01616 | -0.6611 | -0.5094 | 1.0971 | 0.8770 | 0.9284 | 0.6658 | |
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9759.002 | uM | 0.01110 | 0.01416 | -0.6775 | -0.6538 | 3.4304 | 0.9680 | 0.9984 | 1.1336 | |
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9760.002 | uM | 0.01096 | 0.01359 | -0.7597 | -0.7232 | 4.1677 | 1.0345 | 0.9988 | 0.9910 | |
| SK-BR-3 | HER2amp | Luminal | Taxol | TUBB | TUBB | 12999.002 | uM | 0.01340 | 0.01801 | -0.6045 | -0.5861 | 2.6195 | 0.9107 | 0.9991 | 0.8869 | |
| SK-BR-3 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 11851.159 | uM | 0.59463 | 1.28690 | -0.9498 | -1.0000 | 1.4230 | 0.5576 | 0.9844 | 1.2582 | |
| SK-BR-3 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 11851.135 | uM | 52.23540 | 32.71270 | 0.4519 | 0.4514 | 4.9802 | 0.0546 | 0.9305 | 1.2721 | |
| SK-BR-3 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 11851.144 | uM | 0.06058 | 12.84280 | -0.4331 | -1.0000 | 0.2051 | 0.6356 | 0.8932 | 1.3716 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9760.121 | uM | 0.01076 | 0.08106 | -0.7425 | -0.7598 | 0.4576 | 0.9751 | 0.9731 | 1.0265 | |
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 10127.121 | uM | 0.02728 | 0.06832 | -0.8286 | -0.6870 | 0.9417 | 0.9499 | 0.9846 | 1.1088 |