Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7917.05 | uM | 0.07638 | 0.10187 | -0.8935 | -0.5108 | 2.4441 | 0.7937 | 0.9560 | 2.7707 | |
| SUM149PT | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9830.037 | uM | 0.09982 | 0.11760 | -0.7885 | -0.6346 | 5.0000 | 0.8785 | 0.9922 | 1.9735 | |
| SUM149PT | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 10819.143 | uM | 151.47010 | 486.00090 | -0.1480 | -0.4468 | 0.5477 | 0.3192 | 0.9850 | 2.2570 | |
| SUM149PT | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 11937.143 | uM | 106.82530 | 436.03180 | -0.2445 | -0.5597 | 0.5340 | 0.3543 | 0.9875 | 2.3169 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 9830.017 | uM | 97.75580 | 883.00870 | -0.6719 | -0.9999 | 0.4991 | 0.5226 | 0.9934 | 1.8576 | |
| SUM149PT | TNBC | Basal B | 5-FU | TYMS | TYMS | 7917.13 | uM | 178.68030 | 1000.00000 | -0.5424 | -0.8116 | 0.5600 | 0.4480 | 0.9950 | 2.7649 | |
| SUM149PT | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 11937.158 | uM | 0.19185 | 1.70740 | -0.8261 | -1.0000 | 0.5026 | 0.6361 | 0.9481 | 2.2386 | |
| SUM149PT | TNBC | Basal B | AG1024 | IGF1R | RTK | 7530.066 | uM | inf | 11.32170 | 0.5974 | 0.5039 | 1.3545 | 0.0429 | 0.9508 | 1.9710 | |
| SUM149PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 9830.019 | uM | inf | 0.16990 | 0.3903 | 0.5046 | 1.4876 | 0.2572 | 0.9522 | 1.9053 | |
| SUM149PT | TNBC | Basal B | AG1478 | EGFR | ErbB | 7917.016 | uM | 8.7680 | 37.27210 | -0.6003 | -1.0000 | 0.7592 | 0.3227 | 0.9710 | 2.9532 | |
| SUM149PT | TNBC | Basal B | AS-252424 | PI3K | PI3K | 10819.153 | uM | inf | 5.99850 | 0.6630 | 0.6629 | 4.9979 | 0.0472 | 0.9493 | 2.0690 | |
| SUM149PT | TNBC | Basal B | AS-252424 | PI3K | PI3K | 11937.158 | uM | 13.12290 | 7.32360 | 0.3519 | 0.3447 | 2.0042 | 0.1066 | 0.9910 | 2.2386 | |
| SUM149PT | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10819.072 | uM | 37.0360 | 125.77650 | 0.0119 | -0.7892 | 0.7747 | 0.1821 | 0.9640 | 2.1878 | |
| SUM149PT | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7530.073 | uM | 87.51990 | 149.56760 | -0.1135 | -1.0000 | 2.0501 | 0.1247 | 0.9713 | 2.2072 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 15330.203 | uM | 0.00376 | 0.00649 | -0.8564 | -0.7184 | 1.6353 | 1.2319 | 0.9909 | 1.2836 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 15330.203 | uM | 0.00376 | 0.00649 | -0.8564 | -0.7184 | 1.6353 | 1.2319 | 0.9909 | 1.2836 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7530.074 | uM | 0.05589 | 0.08823 | -0.8823 | -0.8633 | 2.1969 | 1.0962 | 0.9992 | 2.0964 | |
| SUM149PT | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7530.074 | uM | 0.05589 | 0.08823 | -0.8823 | -0.8633 | 2.1969 | 1.0962 | 0.9992 | 2.0964 | |
| SUM149PT | TNBC | Basal B | Bosutinib | Src | nRTK | 10819.145 | uM | 1.11820 | 2.40540 | -0.7312 | -0.7053 | 1.1486 | 0.5183 | 0.9865 | 2.1971 | |
| SUM149PT | TNBC | Basal B | Bosutinib | Src | nRTK | 11937.145 | uM | 0.84174 | 2.80980 | -0.8457 | -0.9661 | 0.8924 | 0.5737 | 0.9930 | 2.3618 | |
| SUM149PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 9830.011 | uM | 16.36670 | 37.26730 | -0.7644 | -0.8401 | 1.1981 | 0.5199 | 0.9951 | 2.0792 | |
| SUM149PT | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 7917.075 | uM | 24.81130 | 52.4970 | -0.7567 | -0.8108 | 1.2859 | 0.4721 | 0.9976 | 3.0479 | |
| SUM149PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9830.006 | uM | inf | 0.00358 | 0.5005 | 0.5059 | 0.9961 | 0.2289 | 0.7950 | 1.7160 | |
| SUM149PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7917.018 | uM | inf | 0.00429 | 0.7314 | 0.7201 | 0.5618 | 0.1115 | 0.9341 | 2.8573 | |
| SUM149PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9830.006 | uM | 58.67610 | 450.06120 | -0.9195 | -1.0000 | 0.5392 | 0.4828 | 0.8702 | 1.7160 |