Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM149PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7917.018 | uM | 149.12370 | 996.38530 | -0.6063 | -1.0000 | 0.5784 | 0.3765 | 0.9415 | 2.8573 | ||
| SUM149PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7917.13 | uM | 2.12970 | 4.0810 | -0.8198 | -0.7773 | 1.4422 | 0.5773 | 0.9939 | 2.7649 | |
| SUM149PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9830.017 | uM | 2.21520 | 4.44660 | -0.9393 | -0.9447 | 1.5228 | 0.6009 | 0.9970 | 1.8576 | |
| SUM149PT | TNBC | Basal B | Dactolisib | PI3K | PI3K | 11937.155 | uM | inf | 0.10026 | 0.5758 | 0.5108 | 1.8948 | 0.2623 | 0.6188 | 2.4784 | |
| SUM149PT | TNBC | Basal B | Dactolisib | PI3K | PI3K | 10819.155 | uM | 0.48655 | 0.42552 | 0.1893 | 0.2442 | 5.0000 | 0.2523 | 0.9818 | 2.0561 | |
| SUM149PT | TNBC | Basal B | Dichloroacetate | PDK | PDK | 13123.176 | uM | inf | inf | 0.6345 | 0.6345 | 0.0000 | 0.1874 | 0.1319 | 1.1020 | |
| SUM149PT | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 13123.174 | uM | inf | inf | -0.0732 | -0.0732 | 0.0000 | 0.2459 | 0.2528 | 1.0408 | |
| SUM149PT | TNBC | Basal B | Docetaxel | TUBB | TUBB | 9830.002 | uM | 0.00179 | 0.00180 | -0.0390 | -0.0047 | 2.1102 | 0.6781 | 0.950 | 1.9252 | |
| SUM149PT | TNBC | Basal B | Epirubicin | TOP2 | TOP | 9830.017 | uM | 0.25888 | 0.56835 | -0.9769 | -0.9014 | 1.3105 | 0.8282 | 0.9964 | 1.8576 | |
| SUM149PT | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7530.091 | uM | 4.56080 | 1.40830 | 0.2650 | 0.2207 | 0.4954 | 0.2313 | 0.9294 | 2.0794 | |
| SUM149PT | TNBC | Basal B | Etoposide | TOP2 | TOP | 7530.074 | uM | 4.22870 | 22.1520 | -0.3573 | -0.7406 | 0.5487 | 0.4231 | 0.9667 | 2.0964 | |
| SUM149PT | TNBC | Basal B | Everolimus | MTOR | MTOR | 11937.164 | uM | 14.03820 | 27.25510 | -0.6684 | -1.0000 | 1.6559 | 0.2818 | 0.8982 | 2.5679 | |
| SUM149PT | TNBC | Basal B | Fascaplysin | CDK4 | CDK | 7530.085 | uM | 0.41679 | 0.65723 | -0.8007 | -0.7968 | 2.0924 | 0.5562 | 0.9982 | 2.1343 | |
| SUM149PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 11937.161 | uM | 25.46940 | 113.63330 | 0.0245 | -1.0000 | 0.7346 | 0.1916 | 0.9352 | 2.4516 | |
| SUM149PT | TNBC | Basal B | FR180204 | ERK1/2 | MAPK | 10819.149 | uM | 20.60350 | 61.52680 | 0.2962 | -1.0000 | 1.0042 | 0.0971 | 0.9784 | 2.0505 | |
| SUM149PT | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 11937.154 | uM | 20.66880 | 41.04130 | 0.1651 | -1.0000 | 1.6016 | 0.1156 | 0.9368 | 2.5304 | |
| SUM149PT | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10819.154 | uM | 32.05760 | 34.71070 | 0.4426 | -0.2426 | 4.9745 | 0.0447 | 0.9691 | 2.0680 | |
| SUM149PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 7917.016 | uM | 11.890 | 154.46670 | 0.2744 | -1.0000 | 0.4284 | 0.1553 | 0.9529 | 2.9532 | |
| SUM149PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9830.019 | uM | 2.08280 | 18.80720 | -0.1896 | -1.0000 | 0.4993 | 0.2513 | 0.9718 | 1.9053 | |
| SUM149PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9830.012 | uM | 0.00575 | 0.00857 | -0.6166 | -0.6015 | 1.9785 | 1.1551 | 0.9977 | 1.8343 | |
| SUM149PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 7917.075 | uM | 0.11826 | 0.23897 | -0.0734 | -0.1244 | 0.3158 | 0.6678 | 0.9308 | 3.0479 | |
| SUM149PT | TNBC | Basal B | Gemcitabine | DNA replication | DNA replication | 9830.011 | uM | 0.02184 | 0.04942 | -0.2371 | -0.2487 | 0.4944 | 0.7563 | 0.9404 | 2.0792 | |
| SUM149PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 10819.15 | uM | 69.42850 | 464.22560 | 0.6339 | -1.0000 | 0.5782 | 0.0678 | 0.9396 | 2.1256 | ||
| SUM149PT | TNBC | Basal B | Glycyl-H-1152 | ROCK2 | 11937.16 | uM | 84.87320 | 21.4970 | 0.5288 | 0.3549 | 0.9008 | 0.0794 | 0.9443 | 2.4144 | ||
| SUM149PT | TNBC | Basal B | GM6001 | MMP | MMP | 7530.096 | uM | 211.7840 | 994.0430 | 0.7438 | -0.5799 | 0.4980 | 0.0564 | 0.7339 | 2.1549 |