Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9759.121 | uM | 0.01180 | 0.03028 | -0.8569 | -0.7685 | 0.9880 | 1.1074 | 0.9933 | 1.2887 | |
| SK-BR-3 | HER2amp | Luminal | Torkinib | 15356.211 | uM | 0.00125 | 0.00492 | -0.3826 | -0.3333 | 0.3720 | 0.8953 | 0.9717 | 1.3112 | |||
| SK-BR-3 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 11851.16 | uM | inf | inf | 0.5162 | 0.5162 | 0.0000 | 0.1050 | 0.4827 | 1.1668 | |
| SK-BR-3 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 7527.093 | uM | inf | 0.51483 | 0.7487 | 0.7738 | 1.1909 | 0.0974 | 0.8955 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9759.012 | uM | inf | inf | 0.9728 | 0.9728 | 0.0000 | -0.0132 | -0.0794 | 1.3591 | |
| SK-BR-3 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7912.05 | uM | inf | 2.69910 | 0.7797 | 0.7795 | 4.9988 | 0.0288 | 0.6573 | 0.4863 | |
| SK-BR-3 | HER2amp | Luminal | Trametinib | MEK | MAPK | 9760.024 | uM | 26.8520 | 23.87430 | 0.6179 | 0.0590 | 1.0680 | 0.0340 | 0.9093 | 1.0234 | |
| SK-BR-3 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 10127.123 | uM | inf | inf | 0.2747 | 0.2747 | 0.0000 | 0.4731 | 0.1249 | 0.8767 | |
| SK-BR-3 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9760.026 | uM | inf | 0.00176 | 0.5020 | 0.5240 | 4.9999 | 0.3121 | 0.9733 | 1.0724 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7526.065 | uM | 7.94180 | 11.34730 | -0.8655 | -0.8559 | 2.7957 | 0.9337 | 0.9770 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 7527.065 | uM | 6.80030 | 9.8410 | -0.7668 | -0.7817 | 2.5470 | 0.8932 | 0.9951 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | Triciribine | AKT | AKT | 7527.074 | uM | 0.08281 | 0.15120 | -0.3600 | -0.3485 | 0.8784 | 0.5615 | 0.9961 | 1.9162 | |
| SK-BR-3 | HER2amp | Luminal | Triciribine | AKT | AKT | 7526.074 | uM | 0.04645 | 0.09799 | -0.5372 | -0.5288 | 0.9668 | 0.6935 | 0.9966 | 1.6506 | |
| SK-BR-3 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 11851.143 | uM | 555.64250 | 1000.00000 | -0.8929 | -0.6958 | 1.4839 | 0.3819 | 0.9386 | 1.4447 | |
| SK-BR-3 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9759.006 | uM | 0.01154 | 0.01323 | -0.9273 | -0.4937 | 4.9999 | 1.1745 | 0.8807 | 1.2714 | |
| SK-BR-3 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7912.018 | uM | 0.01004 | 0.01213 | -0.9507 | -0.7888 | 5.0000 | 1.1511 | 0.9894 | 0.7203 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7526.065 | uM | 35.9820 | 71.440 | -0.8530 | -0.8738 | 1.4737 | 0.8713 | 0.9789 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 7527.065 | uM | 63.06940 | 110.06960 | -0.7896 | -0.8069 | 1.7254 | 0.7559 | 0.9945 | 1.8429 | |
| SK-BR-3 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 11851.157 | uM | 1.89760 | 1.88790 | -0.0293 | 0.0127 | 5.0000 | 0.3580 | 0.9733 | 1.4707 | |
| SK-BR-3 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14221.189 | uM | 0.77832 | 1.0550 | -0.6896 | -0.6826 | 2.8304 | 0.5554 | 0.9987 | 1.5537 | |
| SK-BR-3 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 11851.16 | uM | 26.1590 | 5.3650 | 0.4229 | 0.3228 | 0.6549 | 0.1836 | 0.9224 | 1.1668 | |
| SUM102PT | TNBC | Basal B | Cetuximab | EGFR | ErbB | 9777.124 | uM | 0.90402 | 0.82571 | 0.7689 | 0.1819 | 4.9926 | 0.0036 | 0.6069 | 0.6278 | |
| SUM102PT | TNBC | Basal B | CGC-11047 | Polyamine analogue | 9777.124 | uM | 4.36480 | 8.69780 | -0.9999 | -1.0000 | 1.5934 | 0.7079 | 0.9495 | 0.6278 | ||
| SUM102PT | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9777.049 | uM | inf | inf | 0.8248 | 0.8248 | 0.0000 | 0.1310 | 0.1921 | 0.6254 | |
| SUM102PT | TNBC | Basal B | CPT-11 | TOP1 | TOP | 9777.121 | uM | 17.03440 | 28.67070 | -0.8501 | -1.0000 | 2.1101 | 0.3894 | 0.7610 | 1.2018 |