Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM102PT | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 9777.121 | uM | 0.20985 | 0.31331 | -0.9904 | -0.9119 | 2.5898 | 0.8619 | 0.9879 | 1.2018 | |
| SUM102PT | TNBC | Basal B | Gefitinib | EGFR | ErbB | 9777.049 | uM | 1.19920 | 22.33830 | -0.1102 | -1.0000 | 0.3756 | 0.3435 | 0.7150 | 0.6254 | |
| SUM102PT | TNBC | Basal B | Geldanamycin | HSP90 | HSP90 | 9777.049 | uM | 0.01710 | 0.02148 | -0.7904 | -0.5779 | 3.3677 | 1.1473 | 0.7012 | 0.6254 | |
| SUM102PT | TNBC | Basal B | GSK1070916 | AURK | AURK | 9777.001 | uM | 2.45790 | 5.23750 | -0.9996 | -1.0000 | 1.4522 | 0.3113 | 0.9764 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK461364 | PLK1 | PLK | 9777.001 | uM | 4.61340 | 6.97730 | -0.9996 | -1.0000 | 2.6556 | 0.2639 | 0.9865 | 0.7223 | |
| SUM102PT | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 9777.001 | uM | 6.42430 | 7.6240 | -0.6754 | -0.6765 | 4.9976 | 0.1507 | 0.9924 | 0.7223 | |
| SUM102PT | TNBC | Basal B | Topotecan | TOP1 | TOP | 9777.121 | uM | 0.55575 | 0.94805 | -0.9904 | -0.9966 | 2.0527 | 0.8385 | 0.9333 | 1.2018 | |
| SUM102PT | TNBC | Basal B | Trastuzumab | HER2 | ErbB | 9777.124 | uM | inf | inf | 0.8331 | 0.8331 | 0.0000 | 0.0175 | 0.2896 | 0.6278 | |
| SUM1315MO2 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7529.016 | uM | inf | inf | 0.8150 | 0.8150 | 0.0000 | 0.0987 | 0.4662 | 0.5847 | ||
| SUM1315MO2 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 9797.019 | uM | 33.61760 | 43.21490 | -0.9984 | -1.0000 | 4.3746 | 0.1648 | 0.9963 | 0.4912 | ||
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 9797.037 | uM | 0.01326 | 0.02914 | -1.0000 | -0.7749 | 1.1894 | 1.0997 | 0.9485 | 0.3871 | |
| SUM1315MO2 | TNBC | Basal B | 17-AAG | HSP90 | HSP90 | 7529.05 | uM | 0.03054 | 0.04807 | -0.9490 | -0.7778 | 2.0672 | 1.0691 | 0.9775 | 0.4921 | |
| SUM1315MO2 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 12428.143 | uM | 633.20370 | 1000.00000 | -0.2162 | -0.3568 | 1.1787 | 0.1541 | 0.9809 | 0.7057 | |
| SUM1315MO2 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 10875.143 | uM | 466.96250 | 1000.00000 | -0.0083 | -0.3297 | 0.6650 | 0.2101 | 0.9838 | 0.8219 | |
| SUM1315MO2 | TNBC | Basal B | 5-FU | TYMS | TYMS | 9797.017 | uM | 294.50090 | 1000.00000 | -0.7827 | -0.9123 | 0.8494 | 0.4993 | 0.9479 | 0.4824 | |
| SUM1315MO2 | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 12428.165 | uM | 0.07880 | 1.06620 | -0.9973 | -1.0000 | 0.4217 | 0.6977 | 0.9477 | 0.7051 | |
| SUM1315MO2 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7528.066 | uM | 8.2990 | 3.79150 | 0.3943 | 0.3834 | 1.8589 | 0.1102 | 0.9793 | 1.0258 | |
| SUM1315MO2 | TNBC | Basal B | AG1024 | IGF1R | RTK | 10381.066 | uM | 6.1270 | 5.84080 | 0.1059 | 0.1057 | 4.9642 | 0.1378 | 0.9898 | 1.4484 | |
| SUM1315MO2 | TNBC | Basal B | AG1024 | IGF1R | RTK | 9044.066 | uM | 6.0680 | 5.79190 | 0.1040 | 0.1039 | 4.9995 | 0.1054 | 0.9913 | 0.8552 | |
| SUM1315MO2 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7529.016 | uM | 2.96190 | 3.04390 | 0.0087 | -0.0072 | 0.5268 | 0.3345 | 0.9160 | 0.5847 | |
| SUM1315MO2 | TNBC | Basal B | AG1478 | EGFR | ErbB | 9797.019 | uM | 0.10528 | 0.10394 | -0.0189 | 0.0063 | 0.9966 | 0.5854 | 0.9663 | 0.4912 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 10875.153 | uM | 17.11190 | 39.1620 | 0.0941 | -1.0000 | 1.3269 | 0.1067 | 0.8603 | 0.8455 | |
| SUM1315MO2 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 12428.165 | uM | 8.4980 | 8.23310 | 0.0739 | 0.0730 | 4.9850 | 0.0740 | 0.9910 | 0.7051 | |
| SUM1315MO2 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10381.072 | uM | 47.43780 | 29.84120 | 0.4484 | 0.4482 | 4.8929 | 0.0609 | 0.9830 | 1.2411 | |
| SUM1315MO2 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 10875.072 | uM | 16.00650 | 26.54880 | -0.1848 | -0.3544 | 1.0589 | 0.2039 | 0.9834 | 0.7958 |