Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 10874.148 | uM | inf | inf | 0.9329 | 0.9329 | 0.0000 | 0.0954 | 0.0789 | 0.6972 | |
| MX1 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 12220.135 | uM | 1.17960 | 1.72690 | -0.9001 | -0.8935 | 2.6890 | 0.6834 | 0.9144 | 0.6564 | |
| MX1 | Unknown | Unknown | Pevonedistat | NAE1 | NAE1 | 10644.135 | uM | 1.72590 | 2.57450 | -0.9306 | -0.8286 | 2.4439 | 0.5153 | 0.9521 | 0.5273 | |
| MX1 | Unknown | Unknown | Nelfinavir | 12667.174 | uM | 6.93420 | 10.10980 | -0.9543 | -1.0000 | 2.9138 | 0.1831 | 0.990 | 0.8129 | |||
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 10874.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0057 | -0.0198 | 0.8505 | |
| MX1 | Unknown | Unknown | Nilotinib | ABL | nRTK | 10644.145 | uM | 3.15010 | 3.71960 | -0.5688 | -0.4876 | 4.0955 | 0.4971 | 0.9711 | 0.4300 | |
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 12220.159 | uM | 0.150 | 0.25801 | -0.9998 | -1.0000 | 2.0255 | 1.0392 | 0.9923 | 0.4788 | |
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 10644.14 | uM | 0.66207 | 0.82476 | -1.0000 | -1.0000 | 5.0000 | 0.8690 | 0.9955 | 0.4302 | |
| MX1 | Unknown | Unknown | NSC 663284 | CDC25 | CDC | 10874.152 | uM | 0.62316 | 0.99765 | -0.9943 | -1.0000 | 2.3345 | 0.7910 | 0.9986 | 0.7706 | |
| MX1 | Unknown | Unknown | NU6102 | CDK1/2 | CDK | 10644.147 | uM | 2.23610 | 5.50710 | -1.0000 | -1.0000 | 1.2189 | 0.4234 | 0.9711 | 0.4349 | |
| MX1 | Unknown | Unknown | NU6102 | CDK1/2 | CDK | 10874.147 | uM | 8.77790 | 15.5340 | -0.9506 | -1.0000 | 1.9247 | 0.2286 | 0.9925 | 0.7482 | |
| MX1 | Unknown | Unknown | Nutlin 3a | MDM2 | MDM2 | 7523.066 | uM | 18.27720 | 28.530 | -0.7868 | -1.0000 | 2.4671 | 0.2462 | 0.9331 | 0.8127 | |
| MX1 | Unknown | Unknown | Olomoucine II | CDK1 | CDK | 10644.147 | uM | 6.00730 | 7.48350 | -1.0000 | -1.0000 | 5.0000 | 0.4357 | 0.9851 | 0.4349 | |
| MX1 | Unknown | Unknown | Olomoucine II | CDK1 | CDK | 10874.147 | uM | 5.57140 | 7.10210 | -0.9959 | -0.9966 | 4.5164 | 0.4144 | 0.9985 | 0.7482 | |
| MX1 | Unknown | Unknown | Omipalisib | PI3K | PI3K | 10644.087 | uM | 0.00548 | 0.01873 | -0.9983 | -0.9866 | 0.8862 | 1.1685 | 0.9633 | 0.5708 | |
| MX1 | Unknown | Unknown | Oxamflatin | HDAC | HDAC | 10644.147 | uM | 0.48053 | 0.66182 | -0.9999 | -0.9992 | 3.4303 | 0.7292 | 0.9935 | 0.4349 | |
| MX1 | Unknown | Unknown | Oxamflatin | HDAC | HDAC | 10874.147 | uM | 0.49094 | 1.04360 | -0.9895 | -1.0000 | 1.4568 | 0.6277 | 0.9981 | 0.7482 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 10874.152 | uM | inf | inf | 0.6467 | 0.6467 | 0.0000 | 0.1312 | 0.3463 | 0.7706 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 10644.136 | uM | 80.20970 | 150.0160 | 0.3780 | -0.7441 | 1.4559 | 0.0899 | 0.6828 | 0.5562 | |
| MX1 | Unknown | Unknown | PD 98059 | MEK | MAPK | 12220.159 | uM | 45.76140 | 265.90990 | 0.2868 | -1.0000 | 0.6243 | 0.1443 | 0.7928 | 0.4788 | |
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 12220.155 | uM | inf | inf | 0.1151 | 0.1151 | 0.0000 | 0.3578 | 0.5513 | 0.4858 | |
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 12220.155 | uM | inf | inf | 0.1151 | 0.1151 | 0.0000 | 0.3578 | 0.5513 | 0.4858 | |
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 10874.155 | uM | 13.13740 | 85.26950 | 0.2694 | -1.0000 | 0.5874 | 0.1658 | 0.8268 | 0.8099 | |
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 10874.155 | uM | 13.13740 | 85.26950 | 0.2694 | -1.0000 | 0.5874 | 0.1658 | 0.8268 | 0.8099 | |
| MX1 | Unknown | Unknown | PD184352 | MEK | MAPK | 10644.146 | uM | 6.09890 | 9.03380 | -0.6534 | -0.6758 | 2.1767 | 0.3395 | 0.9581 | 0.5967 |