Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-453
TNBC
Luminal
 MG-132
Proteasome
Proteasome
14646.189
uM
0.14767
0.33884
 -0.8198 -0.7843 1.1358 0.7938
0.9646
 1.0620
MDA-MB-453
TNBC
Luminal
 MG-132
Proteasome
Proteasome
14646.189
uM
0.14767
0.33884
 -0.8198 -0.7843 1.1358 0.7938
0.9646
 1.0620
MDA-MB-453
TNBC
Luminal
 MG-132
Proteasome
Proteasome
12414.17
uM
0.30432
0.37594
 -0.9432 -0.9384 5.0000 0.8330
0.9980
 1.2052
MDA-MB-453
TNBC
Luminal
 MG-132
Proteasome
Proteasome
12414.17
uM
0.30432
0.37594
 -0.9432 -0.9384 5.0000 0.8330
0.9980
 1.2052
MDA-MB-453
TNBC
Luminal
 Pevonedistat
NAE1
NAE1
12414.135
uM
1.43180
1.54350
 -0.0057 -0.0402 1.0294 0.3044
0.9763
 1.1872
MDA-MB-453
TNBC
Luminal
 Nelfinavir
12964.174
uM
5.03420
8.04630
 -0.9964 -1.0000 2.3427 0.2872
0.9802
 0.7885
MDA-MB-453
TNBC
Luminal
 Nelfinavir
13562.174
uM
9.50690
8.91340
 0.1303 0.1283 4.5978 0.0948
0.9810
 0.7219
MDA-MB-453
TNBC
Luminal
 Nilotinib
ABL
nRTK
12414.17
uM
inf
inf
 1.0236 1.0236 0.0000 -0.0344
-4.1820
 1.2052
MDA-MB-453
TNBC
Luminal
 NSC 663284
CDC25
CDC
12414.152
uM
4.71940
6.00170
 -0.9511 -0.9503 4.4304 0.5576
0.9910
 1.1325
MDA-MB-453
TNBC
Luminal
 NU6102
CDK1/2
CDK
12414.147
uM
12.19190
22.89670
 -0.7490 -1.0000 1.7432 0.2564
0.9725
 1.1273
MDA-MB-453
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7515.066
uM
inf
inf
 0.1769 0.1769 0.0000 0.2716
0.3584
 1.2099
MDA-MB-453
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7517.066
uM
inf
17.27850
 0.7373 0.7370 4.9262 0.0086
0.8445
 1.3218
MDA-MB-453
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7516.066
uM
53.74740
128.26540
 0.3891 -0.9998 1.2629 0.0823
0.8723
 1.1944
MDA-MB-453
TNBC
Luminal
 Nutlin 3a
MDM2
MDM2
7518.066
uM
70.81570
392.94420
 0.5031 -1.0000 0.6411 0.0963
0.8884
 1.5326
MDA-MB-453
TNBC
Luminal
 Olomoucine II
CDK1
CDK
12414.147
uM
5.03180
7.50570
 -0.9639 -0.9779 2.7101 0.4953
0.9833
 1.1273
MDA-MB-453
TNBC
Luminal
 Omipalisib
PI3K
PI3K
7515.087
uM
0.00227
0.02639
 -0.8256 -0.9700 0.4394 1.0914
0.9743
 1.1161
MDA-MB-453
TNBC
Luminal
 Omipalisib
PI3K
PI3K
7517.086
uM
0.00895
0.04675
 -0.9208 -0.8781 0.6134 0.9551
0.9920
 1.4126
MDA-MB-453
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
7903.011
uM
4.50520
17.56240
 -0.9477 -1.0000 0.8075 0.5996
0.9788
 1.1535
MDA-MB-453
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9723.12
uM
6.7740
18.81260
 -0.9507 -1.0000 1.0756 0.5693
0.9890
 0.8437
MDA-MB-453
TNBC
Luminal
 Oxaliplatin
DNA cross-linker
DNA cross-linker
9708.011
uM
8.11790
22.72660
 -0.7697 -0.8941 0.9960 0.4927
0.9927
 1.0535
MDA-MB-453
TNBC
Luminal
 Oxamflatin
HDAC
HDAC
12414.147
uM
0.28130
0.67068
 -0.9571 -1.0000 1.2644 0.7743
0.9849
 1.1273
MDA-MB-453
TNBC
Luminal
 PD 98059
MEK
MAPK
12414.152
uM
inf
inf
 0.8854 0.8854 0.0000 0.0813
-0.1652
 1.1325
MDA-MB-453
TNBC
Luminal
 PD173074
FGFR1/3
RTK
7515.093
uM
2.09990
6.39450
 -0.9470 -1.0000 0.9866 0.3963
0.8919
 1.3657
MDA-MB-453
TNBC
Luminal
 PD173074
FGFR1/3
RTK
7516.093
uM
1.9160
8.54890
 -0.4844 -1.0000 0.7346 0.2889
0.9663
 1.3148
MDA-MB-453
TNBC
Luminal
 PD173074
FGFR1/3
RTK
7517.093
uM
2.59110
13.10840
 -0.3003 -0.9890 0.6731 0.2513
0.9877
 1.4869