Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 7516.093 | uM | 2.96630 | 3.9210 | -0.9563 | -0.9566 | 3.8322 | 0.4483 | 0.9950 | 1.3148 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 7517.093 | uM | 2.74660 | 3.69310 | -0.9214 | -0.9311 | 3.5511 | 0.4269 | 0.9966 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7515.092 | uM | 16.4390 | 27.87260 | -0.9604 | -1.0000 | 2.0808 | 0.5674 | 0.9718 | 1.2024 | |
| MDA-MB-453 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7517.091 | uM | 9.01190 | 21.99220 | -0.8943 | -0.9738 | 1.2117 | 0.5607 | 0.9732 | 1.5552 | |
| MDA-MB-453 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7516.092 | uM | 18.17450 | 22.59320 | -0.9966 | -0.9844 | 5.0000 | 0.5268 | 0.9905 | 1.1035 | |
| MDA-MB-453 | TNBC | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 7518.091 | uM | 8.46120 | 19.06220 | -0.9155 | -0.9875 | 1.3423 | 0.5638 | 0.9937 | 1.6174 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 7517.067 | uM | 0.03439 | 0.03835 | -0.9658 | -0.3627 | 5.0000 | 0.6845 | 0.8934 | 1.3778 | |
| MDA-MB-453 | TNBC | Luminal | Ispinesib | KSP | Kinesin | 7518.067 | uM | 0.01798 | 0.02415 | -0.9983 | -0.6977 | 2.9622 | 0.9323 | 0.9711 | 0.7666 | |
| MDA-MB-453 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7515.095 | uM | inf | inf | -0.9794 | -0.9794 | 0.0000 | 0.7184 | 0.4831 | 0.9628 | |
| MDA-MB-453 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7517.095 | uM | 0.00457 | 0.00486 | -0.9304 | -0.0633 | 1.9640 | 0.6882 | 0.6096 | 1.5365 | |
| MDA-MB-453 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7516.095 | uM | 0.00981 | 0.01007 | -0.9552 | -0.0706 | 4.9999 | 0.6551 | 0.6098 | 1.3423 | |
| MDA-MB-453 | TNBC | Luminal | Ixabepilone | TUBB | TUBB | 7518.095 | uM | 0.00193 | 0.00223 | -0.8913 | -0.1868 | 2.2259 | 0.8555 | 0.7508 | 1.4438 | |
| MDA-MB-453 | TNBC | Luminal | JNK-IN-5A | JNK | JNK | 12414.168 | uM | 1.270 | 1.37520 | -0.4961 | -0.2441 | 4.9964 | 0.5078 | 0.8906 | 1.2069 | |
| MDA-MB-453 | TNBC | Luminal | L-779450 | BRAF | MAPK | 12414.166 | uM | inf | 1000.00000 | 0.6341 | -0.0841 | 0.2717 | 0.1078 | 0.7545 | 1.3106 | |
| MDA-MB-453 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7516.098 | uM | 25.84260 | 677.19180 | 0.5439 | -1.0000 | 0.3364 | 0.1388 | 0.7417 | 1.2625 | |
| MDA-MB-453 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7515.098 | uM | 17.48960 | 1.53090 | 0.4989 | 0.4585 | 1.0219 | 0.1186 | 0.8334 | 1.1465 | |
| MDA-MB-453 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7518.098 | uM | 6.77860 | 86.09230 | 0.3255 | -1.0000 | 0.4322 | 0.1598 | 0.9481 | 1.6108 | |
| MDA-MB-453 | TNBC | Luminal | Lapatinib | EGFR/HER2 | ErbB | 7517.098 | uM | 2.410 | 2.00280 | 0.1796 | 0.0889 | 1.0580 | 0.1698 | 0.9748 | 1.2851 | |
| MDA-MB-453 | TNBC | Luminal | LBH589 | HDAC | HDAC | 12414.167 | uM | 0.04797 | 0.05925 | -0.9352 | -0.9371 | 5.0000 | 0.9336 | 0.9987 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12414.167 | uM | 0.64209 | 1.94630 | -0.9565 | -1.0000 | 0.9907 | 0.4364 | 0.9913 | 1.2130 | |
| MDA-MB-453 | TNBC | Luminal | Mebendazole | 12964.174 | uM | 0.21977 | 0.29241 | -0.4032 | -0.2943 | 1.6205 | 0.5795 | 0.9637 | 0.7885 | |||
| MDA-MB-453 | TNBC | Luminal | Mebendazole | 13562.174 | uM | 0.10597 | 0.12962 | -0.3553 | -0.2507 | 2.0171 | 0.6156 | 0.9838 | 0.7219 | |||
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 7517.084 | uM | inf | 0.03602 | 0.6571 | 0.7142 | 0.6438 | 0.1970 | 0.8099 | 1.4076 | |
| MDA-MB-453 | TNBC | Luminal | Methotrexate | DHFR | Metabolism | 7518.084 | uM | inf | 0.10744 | 0.7409 | 0.7877 | 5.0000 | 0.1325 | 0.8790 | 1.3244 | |
| MDA-MB-453 | TNBC | Luminal | Methylglyoxal | 13647.184 | uM | inf | inf | -0.8749 | -0.8749 | 0.0000 | 0.3852 | 0.4269 | 1.2942 |