Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | PD184352 | MEK | MAPK | 12333.155 | uM | inf | inf | 0.7011 | 0.7011 | 0.0000 | 0.0780 | 0.5724 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | PD184352 | MEK | MAPK | 12333.155 | uM | inf | inf | 0.7011 | 0.7011 | 0.0000 | 0.0780 | 0.5724 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7510.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0419 | -8.1247 | 0.8152 | |
| MDA-MB-415 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7512.095 | uM | inf | inf | 0.8257 | 0.8257 | 0.0000 | 0.0736 | 0.0000 | 0.8452 | |
| MDA-MB-415 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7511.095 | uM | inf | 0.05330 | 0.6055 | 0.6600 | 0.5805 | 0.2746 | 0.7635 | 1.1565 | |
| MDA-MB-415 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7512.065 | uM | inf | inf | 0.9567 | 0.9567 | 0.0000 | 0.0006 | 0.1478 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7511.065 | uM | inf | inf | 0.9780 | 0.9780 | 0.0000 | 0.0568 | 0.1924 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | PS-1145 | IKK | NFKB | 7510.065 | uM | inf | inf | 0.8713 | 0.8713 | 0.0000 | 0.0068 | 0.3129 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7511.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0461 | -21.9241 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7512.067 | uM | inf | inf | 1.0267 | 1.0267 | 0.0000 | -0.0348 | -1.5841 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7510.067 | uM | 170.140 | 174.92770 | 0.5243 | -0.0744 | 5.0000 | 0.0185 | 0.8706 | 0.8348 | |
| MDA-MB-415 | HR+ | Luminal | Ribavirin | 15325.211 | uM | 111.08590 | 59.48180 | 0.6204 | 0.1914 | 0.7727 | 0.0371 | 0.8888 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10938.144 | uM | inf | inf | 0.4637 | 0.4637 | 0.0000 | 0.2410 | 0.4109 | 1.1369 | |
| MDA-MB-415 | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 12333.168 | uM | 10.84550 | 18.51560 | -0.9988 | -1.0000 | 2.0540 | 0.3650 | 0.9888 | 0.5815 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 12333.155 | uM | 1.8070 | 19.85380 | -0.2260 | -1.0000 | 0.4584 | 0.3220 | 0.9946 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10938.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12333.165 | uM | 0.17777 | 1.04950 | -0.9950 | -1.0000 | 0.6187 | 0.7648 | 0.9148 | 0.6207 | |
| MDA-MB-415 | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10938.153 | uM | 8.03970 | 10.01450 | -0.9996 | -0.9994 | 5.0000 | 0.3668 | 0.9294 | 0.4228 | |
| MDA-MB-415 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7510.068 | uM | 0.00143 | 0.00123 | 0.0726 | 0.0555 | 0.7570 | 0.8274 | 0.9007 | 0.7539 | |
| MDA-MB-415 | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7512.069 | uM | 0.00214 | 0.00191 | -0.1700 | 0.0447 | 0.8144 | 0.7014 | 0.9143 | 0.8684 | |
| MDA-MB-415 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7511.084 | uM | 105.12280 | 70.09760 | 0.0906 | 0.4331 | 4.9649 | 0.1391 | 0.6533 | 1.1467 | |
| MDA-MB-415 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7510.084 | uM | 13.99840 | 635.2080 | -0.2676 | -1.0000 | 0.2880 | 0.3960 | 0.6651 | 0.8702 | |
| MDA-MB-415 | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7512.084 | uM | 531.91040 | 609.73640 | -0.1657 | -0.3420 | 3.8168 | 0.0476 | 0.9879 | 0.7511 | |
| MDA-MB-415 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7511.067 | uM | inf | inf | -0.9799 | -0.9799 | 0.0000 | 0.3057 | 0.4468 | 1.1247 | |
| MDA-MB-415 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7510.067 | uM | 4.98990 | 6.21590 | -0.9998 | -0.9998 | 5.0000 | 0.5373 | 0.9931 | 0.8348 |