Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7512.067 | uM | 5.46730 | 7.47020 | -0.9990 | -0.9999 | 3.5194 | 0.4733 | 0.9986 | 0.8735 | |
| MDA-MB-415 | HR+ | Luminal | Taxol | TUBB | TUBB | 7897.002 | uM | 0.00585 | 0.00625 | -0.0901 | -0.0289 | 0.8488 | 0.6826 | 0.9759 | 0.8381 | |
| MDA-MB-415 | HR+ | Luminal | Taxol | TUBB | TUBB | 9664.002 | uM | 0.00381 | 0.00666 | -0.4486 | -0.4175 | 1.0850 | 0.9491 | 0.9767 | 0.5947 | |
| MDA-MB-415 | HR+ | Luminal | Taxol | TUBB | TUBB | 12959.002 | uM | 0.01303 | 0.01602 | -0.2999 | -0.2056 | 1.6651 | 0.6901 | 0.9903 | 0.3805 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10938.152 | uM | 0.14590 | 0.47903 | -0.7704 | -0.8461 | 0.8330 | 0.6609 | 0.9701 | 0.9498 | |
| MDA-MB-415 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 12333.152 | uM | 0.91692 | 1.06790 | -0.6124 | -0.5714 | 5.0000 | 0.4605 | 0.9912 | 0.7371 | |
| MDA-MB-415 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12333.135 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0098 | 0.0000 | 0.4305 | |
| MDA-MB-415 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10938.148 | uM | inf | inf | 0.7037 | 0.7037 | 0.0000 | 0.3304 | 0.0093 | 0.9949 | |
| MDA-MB-415 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10938.144 | uM | 0.04237 | 3.83940 | -0.9452 | -1.0000 | 0.2438 | 0.6993 | 0.7078 | 1.1369 | |
| MDA-MB-415 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12333.168 | uM | -inf | 0.00841 | -0.9982 | -1.0000 | 0.1818 | 1.2503 | 0.7864 | 0.5815 | |
| MDA-MB-415 | HR+ | Luminal | Topotecan | TOP1 | TOP | 7897.007 | uM | 0.12632 | 0.24378 | -0.4471 | -0.4772 | 1.0192 | 0.7286 | 0.9699 | 0.8772 | |
| MDA-MB-415 | HR+ | Luminal | Topotecan | TOP1 | TOP | 9664.121 | uM | 0.20863 | 0.38286 | -0.6418 | -0.6836 | 1.4194 | 0.7372 | 0.9899 | 0.7294 | |
| MDA-MB-415 | HR+ | Luminal | Torkinib | 15325.211 | uM | 0.00156 | 0.03995 | -0.8858 | -1.0000 | 0.3386 | 1.0873 | 0.9950 | 1.1289 | |||
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10938.15 | uM | inf | inf | 0.0922 | 0.0922 | 0.0000 | 0.3397 | 0.5310 | 1.0480 | |
| MDA-MB-415 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12333.169 | uM | 0.22492 | 1.75640 | -0.9835 | -1.0000 | 0.5345 | 0.6952 | 0.9297 | 0.5536 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 7897.036 | uM | 0.73853 | 5.93930 | 0.1448 | -0.5224 | 0.3431 | 0.3177 | 0.8833 | 0.8072 | |
| MDA-MB-415 | HR+ | Luminal | Trametinib | MEK | MAPK | 7897.012 | uM | 0.49405 | 0.26878 | 0.3063 | 0.3122 | 1.6088 | 0.2477 | 0.9710 | 0.7808 | |
| MDA-MB-415 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9664.124 | uM | 28.74090 | 3.15370 | 0.6147 | 0.4483 | 1.0265 | 0.0497 | 0.8757 | 0.8433 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7511.065 | uM | 17.26430 | 26.25970 | -0.8342 | -0.5710 | 1.8163 | 0.6978 | 0.9013 | 1.2217 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7510.065 | uM | 6.14620 | 13.40580 | -0.9788 | -0.9488 | 1.3642 | 0.9032 | 0.9937 | 0.6831 | |
| MDA-MB-415 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7512.065 | uM | 16.12210 | 31.73240 | -0.8337 | -0.7584 | 1.3631 | 0.6942 | 0.9948 | 0.9176 | |
| MDA-MB-415 | HR+ | Luminal | Triciribine | AKT | AKT | 7510.074 | uM | 0.08386 | 0.68323 | -0.3524 | -0.6667 | 0.4039 | 0.5518 | 0.9555 | 0.7920 | |
| MDA-MB-415 | HR+ | Luminal | Triciribine | AKT | AKT | 7512.074 | uM | 0.05781 | 2.1340 | -0.3878 | -1.0000 | 0.3045 | 0.5884 | 0.9829 | 0.9022 | |
| MDA-MB-415 | HR+ | Luminal | Triciribine | AKT | AKT | 7511.074 | uM | 0.56383 | 7.87840 | -0.3265 | -1.0000 | 0.4166 | 0.3867 | 0.9912 | 1.2617 | |
| MDA-MB-415 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 10938.143 | uM | 70.01430 | 1000.00000 | -0.7670 | -0.9799 | 0.4081 | 0.5513 | 0.7275 | 1.0173 |