Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 7506.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0433 | 0.1148 | 1.0475 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7506.067 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0384 | -4.1641 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7508.067 | uM | inf | inf | 0.9152 | 0.9152 | 0.0000 | 0.0635 | -0.0871 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 7507.067 | uM | inf | 42.87520 | 0.5042 | 0.5025 | 4.1650 | 0.0484 | 0.9676 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | QNZ | NFkB | NFKB | 7506.096 | uM | inf | 0.09549 | 0.5541 | 0.5787 | 5.0000 | 0.1867 | 0.9423 | 1.0303 | |
| MDA-MB-361 | HER2amp | Luminal | Ribavirin | 15396.211 | uM | inf | inf | 0.6490 | 0.6490 | 0.0000 | 0.0581 | 0.5449 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Ro 32-0432 | PKC | PKC | 10643.142 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0284 | -0.7438 | 0.5166 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 10643.144 | uM | inf | inf | 0.6511 | 0.6511 | 0.0000 | 0.1255 | 0.5049 | 0.7178 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 10999.144 | uM | inf | 33.74850 | 0.8575 | 0.8559 | 4.1065 | -0.0135 | 0.6799 | 0.6880 | |
| MDA-MB-361 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 12379.168 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.4672 | |
| MDA-MB-361 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10999.155 | uM | inf | inf | 0.9727 | 0.9727 | 0.0000 | -0.0387 | -1.6882 | 0.7370 | |
| MDA-MB-361 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10643.146 | uM | 64.07680 | 64.55990 | 0.7729 | -0.0187 | 4.8871 | 0.0187 | 0.7113 | 0.6436 | |
| MDA-MB-361 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 12379.155 | uM | inf | 0.13118 | 0.7207 | 0.7660 | 4.9997 | 0.1286 | 0.7223 | 0.3793 | |
| MDA-MB-361 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 12379.165 | uM | 0.96508 | 2.0870 | -1.0000 | -1.0000 | 1.4244 | 0.6024 | 0.9805 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10999.153 | uM | 0.86334 | 2.70270 | -0.9819 | -1.0000 | 0.9627 | 0.5268 | 0.9912 | 0.6626 | |
| MDA-MB-361 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10643.141 | uM | 0.64371 | 1.47930 | -0.9985 | -0.9959 | 1.3171 | 0.5920 | 0.9925 | 0.4846 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7505.068 | uM | 1.84330 | 115.01230 | -0.3095 | -1.0000 | 0.2658 | 0.4120 | 0.8280 | 1.2083 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7895.068 | uM | 1.2260 | 99.94940 | -0.2549 | -1.0000 | 0.2496 | 0.4367 | 0.8857 | 1.1356 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7507.068 | uM | 0.28369 | 0.04714 | 0.2873 | 0.3599 | 0.7087 | 0.3909 | 0.9522 | 1.0877 | |
| MDA-MB-361 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 7508.069 | uM | 0.05574 | 0.02729 | 0.1453 | 0.1622 | 0.5493 | 0.4557 | 0.9793 | 0.6735 | |
| MDA-MB-361 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7508.084 | uM | 190.85780 | 199.9580 | -0.1308 | -0.1311 | 5.0000 | 0.1752 | 0.9011 | 0.7756 | |
| MDA-MB-361 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7507.084 | uM | 38.79150 | 72.3010 | -0.3943 | -0.4569 | 1.0425 | 0.3307 | 0.9774 | 1.1207 | |
| MDA-MB-361 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7506.085 | uM | 51.11260 | 68.65190 | -0.7144 | -0.7284 | 3.0467 | 0.2167 | 0.9870 | 1.0985 | |
| MDA-MB-361 | HER2amp | Luminal | Sulindac sulfide | COX1/2 | COX | 10643.136 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0432 | -6.6439 | 0.5141 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7508.067 | uM | 9.14220 | 11.38870 | -0.9994 | -1.0000 | 5.0000 | 0.4106 | 0.9941 | 0.7560 |