Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7506.067 | uM | 10.01710 | 12.5920 | -0.9893 | -0.9891 | 4.7703 | 0.3564 | 0.9975 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7507.067 | uM | 10.12420 | 12.62160 | -0.9927 | -0.9927 | 4.9608 | 0.3689 | 0.9986 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 7506.096 | uM | inf | inf | 0.9262 | 0.9262 | 0.0000 | 0.0039 | 0.4959 | 1.0303 | ||
| MDA-MB-361 | HER2amp | Luminal | Taxol | TUBB | TUBB | 10095.002 | uM | 0.01170 | 0.01561 | -0.3006 | -0.2285 | 1.3074 | 0.7200 | 0.9858 | 0.9451 | |
| MDA-MB-361 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9648.002 | uM | 0.00838 | 0.01237 | -0.4664 | -0.3862 | 1.4685 | 0.8253 | 0.9863 | 0.6465 | |
| MDA-MB-361 | HER2amp | Luminal | Taxol | TUBB | TUBB | 12989.002 | uM | 0.01962 | 0.02213 | -0.2976 | -0.2415 | 3.2768 | 0.7055 | 0.9927 | 0.6028 | |
| MDA-MB-361 | HER2amp | Luminal | Taxol | TUBB | TUBB | 7896.002 | uM | 0.01873 | 0.02373 | -0.2472 | -0.2042 | 1.4486 | 0.6584 | 0.9928 | 1.1441 | |
| MDA-MB-361 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 10999.152 | uM | 0.39927 | 0.62881 | -0.6058 | -0.5803 | 1.6960 | 0.5018 | 0.9938 | 0.8426 | |
| MDA-MB-361 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 10643.14 | uM | 0.21852 | 0.35230 | -0.9959 | -0.9170 | 2.1810 | 0.6385 | 0.9961 | 0.5078 | |
| MDA-MB-361 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 12379.152 | uM | 0.27085 | 0.33716 | -0.9958 | -0.9933 | 4.9966 | 0.6552 | 0.9985 | 0.5297 | |
| MDA-MB-361 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12379.135 | uM | inf | inf | 1.0351 | 1.0351 | 0.0000 | -0.0361 | -2.8027 | 0.4972 | |
| MDA-MB-361 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10999.135 | uM | inf | inf | 0.9115 | 0.9115 | 0.0000 | 0.0000 | 0.5254 | 0.4857 | |
| MDA-MB-361 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10643.144 | uM | 0.00033 | 0.26653 | -0.9989 | -1.0000 | 0.1640 | 0.9661 | 0.6596 | 0.7178 | |
| MDA-MB-361 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10999.144 | uM | 0.10770 | 2.01460 | -0.9966 | -1.0000 | 0.3751 | 0.7048 | 0.9305 | 0.6880 | |
| MDA-MB-361 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 12379.168 | uM | 0.09553 | 1.17070 | -0.9997 | -1.0000 | 0.4384 | 0.7284 | 0.9384 | 0.4672 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9648.121 | uM | 0.01942 | 0.03104 | -0.9592 | -0.5489 | 1.5797 | 0.9350 | 0.9447 | 0.6537 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7505.078 | uM | 0.90785 | 8.47040 | -0.5672 | -1.0000 | 0.4919 | 0.4963 | 0.9562 | 1.1847 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7896.007 | uM | 0.15569 | 2.04390 | -0.8142 | -1.0000 | 0.4267 | 0.6498 | 0.9596 | 1.1203 | |
| MDA-MB-361 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7896.043 | uM | 3.95630 | 61.42520 | -0.1364 | -1.0000 | 0.4006 | 0.3302 | 0.9823 | 0.8553 | |
| MDA-MB-361 | HER2amp | Luminal | Torkinib | 15396.211 | uM | 0.00334 | 0.01326 | -0.6071 | -0.6008 | 0.5726 | 1.0084 | 0.9991 | 0.9137 | |||
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12379.169 | uM | 5.92640 | 15.43440 | -0.9947 | -1.0000 | 1.1478 | 0.3770 | 0.9244 | 0.5957 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10999.15 | uM | 1.93980 | 38.02360 | -0.0069 | -1.0000 | 0.3692 | 0.2764 | 0.9441 | 0.7928 | |
| MDA-MB-361 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10643.138 | uM | 4.41480 | 12.29050 | -1.0000 | -1.0000 | 1.0730 | 0.3544 | 0.9705 | 0.4981 | |
| MDA-MB-361 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 7506.093 | uM | inf | inf | 0.7940 | 0.7940 | 0.0000 | -0.0107 | 0.1828 | 0.9162 | |
| MDA-MB-361 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 10472.1 | uM | inf | inf | 0.4171 | 0.4171 | 0.0000 | 0.2056 | 0.4634 | 0.6324 |