Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Vinorelbine | TUBB | TUBB | 7892.018 | uM | 0.05042 | 2.96730 | -0.6791 | -1.0000 | 0.2696 | 0.5860 | 0.7512 | 2.4903 | |
| MDA-MB-231 | TNBC | Basal B | Vorinostat | HDAC | HDAC | 7504.065 | uM | 157.92660 | 175.61610 | -0.6752 | -0.3502 | 5.0000 | 0.4481 | 0.9153 | 1.6220 | |
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9648.132 | uM | inf | inf | 0.7888 | 0.7888 | 0.0000 | 0.2124 | 0.0572 | 0.7147 | ||
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7505.016 | uM | inf | inf | 0.8207 | 0.8207 | 0.0000 | 0.1123 | 0.2810 | 1.0721 | ||
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7896.016 | uM | inf | 8.69110 | 0.4955 | 0.6398 | 5.0000 | 0.1295 | 0.6325 | 0.8912 | ||
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7894.016 | uM | inf | 1.34150 | 0.7087 | 0.6054 | 0.3015 | 0.1668 | 0.6640 | 0.7753 | ||
| MDA-MB-361 | HER2amp | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7895.016 | uM | 193.48210 | 1000.00000 | 0.4841 | -0.3789 | 0.3434 | 0.1541 | 0.7820 | 1.2977 | ||
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7894.05 | uM | 0.04092 | 0.05025 | -0.7977 | -0.7413 | 4.4267 | 1.0184 | 0.9937 | 0.7608 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7896.05 | uM | 0.05658 | 0.0670 | -0.7111 | -0.6637 | 5.0000 | 0.9191 | 0.9970 | 0.9241 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7895.05 | uM | 0.04768 | 0.05640 | -0.7335 | -0.6576 | 5.0000 | 0.9445 | 0.9973 | 1.1017 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7505.05 | uM | 0.06877 | 0.08306 | -0.8520 | -0.7858 | 5.0000 | 0.9896 | 0.9983 | 0.9037 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 7896.04 | uM | 0.09913 | 0.11658 | -0.6645 | -0.6245 | 4.9993 | 0.8601 | 0.9983 | 1.0776 | |
| MDA-MB-361 | HER2amp | Luminal | 17-AAG | HSP90 | HSP90 | 9648.037 | uM | 0.03015 | 0.0370 | -0.9033 | -0.8903 | 5.0000 | 1.1329 | 0.9991 | 0.6971 | |
| MDA-MB-361 | HER2amp | Luminal | 2-deoxyglucose | 12989.177 | uM | inf | inf | 0.2081 | 0.2081 | 0.0000 | 0.3001 | 0.0090 | 0.3765 | |||
| MDA-MB-361 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 12379.143 | uM | inf | inf | -0.0136 | -0.0136 | 0.0000 | 0.4100 | 0.5206 | 0.4493 | |
| MDA-MB-361 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10643.143 | uM | 270.4330 | 1000.00000 | -0.2242 | -0.6240 | 0.6195 | 0.2931 | 0.9231 | 0.4866 | |
| MDA-MB-361 | HER2amp | Luminal | 5-DFUR | TYMS | TYMS | 10999.143 | uM | 608.25760 | 571.01140 | 0.0736 | 0.0659 | 2.2362 | 0.1704 | 0.9745 | 0.5216 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 9648.017 | uM | 73.7610 | 272.01450 | -0.9821 | -1.0000 | 0.8418 | 0.6700 | 0.9889 | 0.5727 | |
| MDA-MB-361 | HER2amp | Luminal | 5-FU | TYMS | TYMS | 7896.017 | uM | 148.56930 | 627.87090 | -0.8727 | -1.0000 | 0.7623 | 0.5540 | 0.9917 | 1.0113 | |
| MDA-MB-361 | HER2amp | Luminal | Afatinib | EGFR/HER2 | ErbB | 12379.165 | uM | 0.00707 | 0.02452 | -1.0000 | -0.9566 | 0.8596 | 1.1784 | 0.9915 | 0.3550 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7506.066 | uM | inf | inf | 0.9368 | 0.9368 | 0.0000 | 0.0689 | 0.0388 | 1.1486 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7508.066 | uM | inf | inf | 0.9124 | 0.9124 | 0.0000 | 0.0952 | 0.0492 | 0.8980 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 10472.066 | uM | inf | inf | 0.9550 | 0.9550 | 0.0000 | 0.0028 | 0.1818 | 0.7390 | |
| MDA-MB-361 | HER2amp | Luminal | AG1024 | IGF1R | RTK | 7507.066 | uM | 17.420 | 81.54930 | 0.2758 | -1.0000 | 0.7117 | 0.1349 | 0.8819 | 0.9124 | |
| MDA-MB-361 | HER2amp | Luminal | AG1478 | EGFR | ErbB | 7894.016 | uM | 12.34370 | 81.50340 | -0.3479 | -1.0000 | 0.5821 | 0.2546 | 0.9061 | 0.7753 |