Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MDA-MB-175-VII
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
7885.017
uM
4.56790
10.70610
 -0.9853 -1.0000 1.2898 0.5575
0.9725
 0.5647
MDA-MB-175-VII
HR+
Luminal
 Cisplatin
DNA cross-linker
DNA cross-linker
7886.017
uM
3.81950
9.24240
 -0.9929 -1.0000 1.2432 0.5078
0.9980
 0.7230
MDA-MB-175-VII
HR+
Luminal
 CPT-11
TOP1
TOP
7886.043
uM
inf
inf
 0.7238 0.7238 0.0000 0.1011
0.0201
 0.6905
MDA-MB-175-VII
HR+
Luminal
 CPT-11
TOP1
TOP
7886.007
uM
64.61070
73.48460
 0.2662 -0.4513 4.9981 0.0077
0.9667
 0.6601
MDA-MB-175-VII
HR+
Luminal
 Dactolisib
PI3K
PI3K
12126.155
uM
inf
inf
 0.6736 0.6736 0.0000 0.4105
0.2197
 0.6799
MDA-MB-175-VII
HR+
Luminal
 Dactolisib
PI3K
PI3K
10642.146
uM
1.73460
1.64180
 -0.1923 0.1202 5.0000 0.2366
0.8284
 0.7272
MDA-MB-175-VII
HR+
Luminal
 Dactolisib
PI3K
PI3K
10818.155
uM
0.27026
0.31321
 -0.6621 -0.5452 4.9993 0.6641
0.9243
 0.6048
MDA-MB-175-VII
HR+
Luminal
 Dichloroacetate
PDK
PDK
13754.176
uM
inf
inf
 0.7861 0.7861 0.0000 0.1372
-0.1635
 0.7009
MDA-MB-175-VII
HR+
Luminal
 Disulfiram
Proteasome
Proteasome
13754.174
uM
0.08595
0.09019
 -0.2683 -0.1361 5.0000 0.6217
0.8573
 0.4290
MDA-MB-175-VII
HR+
Luminal
 Docetaxel
TUBB
TUBB
7885.002
uM
0.01493
0.01109
 0.3635 0.3870 5.0000 0.3797
0.8742
 0.7110
MDA-MB-175-VII
HR+
Luminal
 Docetaxel
TUBB
TUBB
7886.002
uM
0.01312
0.00590
 0.3827 0.3533 1.5335 0.3606
0.9836
 0.7173
MDA-MB-175-VII
HR+
Luminal
 Doxorubicin
TOP2
TOP
7886.007
uM
0.06009
0.06246
 -0.0494 -0.0222 1.1246 0.5772
0.8122
 0.6601
MDA-MB-175-VII
HR+
Luminal
 Doxorubicin
TOP2
TOP
7886.043
uM
0.96097
1.7670
 -0.4180 -0.3840 0.9356 0.4664
0.9517
 0.6905
MDA-MB-175-VII
HR+
Luminal
 Epirubicin
TOP2
TOP
7885.017
uM
0.17418
0.29584
 -1.0000 -0.7153 1.6766 0.8754
0.9297
 0.5647
MDA-MB-175-VII
HR+
Luminal
 Epirubicin
TOP2
TOP
7886.017
uM
0.14596
0.79196
 -0.9999 -0.9101 0.6131 0.7692
0.9564
 0.7230
MDA-MB-175-VII
HR+
Luminal
 Erlotinib
EGFR
ErbB
7500.091
uM
3.81030
10.64270
 -0.8445 -1.0000 1.0695 0.3690
0.9310
 0.6237
MDA-MB-175-VII
HR+
Luminal
 Erlotinib
EGFR
ErbB
7499.09
uM
2.23560
9.95290
 -0.6834 -1.0000 0.7357 0.3769
0.9773
 0.9238
MDA-MB-175-VII
HR+
Luminal
 Etoposide
TOP2
TOP
7500.074
uM
inf
inf
 -0.3130 -0.3130 0.0000 0.3186
0.5305
 0.5279
MDA-MB-175-VII
HR+
Luminal
 Etoposide
TOP2
TOP
7499.074
uM
60.01290
35.59120
 0.2881 0.1493 0.6787 0.1438
0.9532
 0.7239
MDA-MB-175-VII
HR+
Luminal
 Everolimus
MTOR
MTOR
12126.164
uM
0.38555
40.55220
 -0.4386 -1.0000 0.2360 0.4615
0.7129
 0.7532
MDA-MB-175-VII
HR+
Luminal
 Fascaplysin
CDK4
CDK
7499.084
uM
0.19324
0.34146
 -0.9999 -1.0000 1.9299 0.8039
0.9733
 0.7991
MDA-MB-175-VII
HR+
Luminal
 Fascaplysin
CDK4
CDK
7500.084
uM
0.21424
0.26681
 -0.9999 -0.9980 5.0000 0.7816
0.9866
 0.5811
MDA-MB-175-VII
HR+
Luminal
 FR180204
ERK1/2
MAPK
12126.161
uM
4.58940
18.68790
 -0.7195 -1.0000 0.7824 0.4917
0.6752
 0.6227
MDA-MB-175-VII
HR+
Luminal
 FR180204
ERK1/2
MAPK
10818.149
uM
12.41830
36.05710
 0.0388 -1.0000 1.0307 0.1795
0.8494
 0.4210
MDA-MB-175-VII
HR+
Luminal
 FR180204
ERK1/2
MAPK
10642.137
uM
17.57520
8.57880
 0.4840 0.4831 4.7236 0.0635
0.9391
 0.6570