Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | PS-1145 | IKK | NFKB | 10419.065 | uM | inf | inf | 1.0047 | 1.0047 | 0.0000 | 0.0356 | 0.0465 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | PS-1145 | IKK | NFKB | 7494.065 | uM | inf | inf | 0.8524 | 0.8524 | 0.0000 | 0.1011 | 0.0710 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 7494.067 | uM | 115.69020 | 269.94080 | 0.3002 | -1.0000 | 1.2966 | 0.1385 | 0.7532 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Ribavirin | 15355.211 | uM | inf | inf | 0.9510 | 0.9510 | 0.0000 | 0.1174 | 0.0035 | 1.0584 | |||
| MDA-MB-134-VI | HR+ | Luminal | Ro 32-0432 | PKC | PKC | 10519.142 | uM | inf | inf | 0.9545 | 0.9545 | 0.0000 | 0.1014 | 0.0933 | 0.8963 | |
| MDA-MB-134-VI | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 12206.144 | uM | inf | inf | 0.7635 | 0.7635 | 0.0000 | 0.1149 | 0.3712 | 0.9811 | |
| MDA-MB-134-VI | HR+ | Luminal | SB-3CT | MMP2/9 | MMP | 10998.144 | uM | inf | inf | 0.8777 | 0.8777 | 0.0000 | 0.0210 | 0.4718 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 10998.155 | uM | 0.62246 | 0.46039 | 0.1837 | 0.0743 | 0.5330 | 0.3611 | 0.9633 | 0.9302 | |
| MDA-MB-134-VI | HR+ | Luminal | Selumetinib | MEK | MAPK | 12206.155 | uM | 0.52536 | 0.31556 | 0.2094 | 0.2025 | 1.0188 | 0.3176 | 0.9896 | 0.9802 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10998.153 | uM | 7.28970 | 15.73960 | -0.9847 | -1.0000 | 1.4273 | 0.3349 | 0.9248 | 0.7434 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 10519.141 | uM | 10.01420 | 17.01780 | -0.9832 | -1.0000 | 2.0719 | 0.2793 | 0.9732 | 1.0417 | |
| MDA-MB-134-VI | HR+ | Luminal | Sigma A6730 | AKT | AKT | 12206.158 | uM | 11.50920 | 17.9770 | -0.9531 | -1.0000 | 2.4636 | 0.2873 | 0.9735 | 1.1431 | |
| MDA-MB-134-VI | HR+ | Luminal | Sirolimus | MTOR | MTOR | 7494.068 | uM | 0.00588 | 0.00409 | 0.1172 | 0.1580 | 1.0481 | 0.6845 | 0.9617 | 0.9185 | |
| MDA-MB-134-VI | HR+ | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7494.084 | uM | 19.43740 | 13.27430 | -0.2174 | 0.2591 | 1.9150 | 0.3274 | 0.5911 | 1.0275 | |
| MDA-MB-134-VI | HR+ | Luminal | Sulindac sulfide | COX1/2 | COX | 10519.136 | uM | inf | inf | 0.9265 | 0.9265 | 0.0000 | 0.0200 | 0.0000 | 1.1406 | |
| MDA-MB-134-VI | HR+ | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7494.067 | uM | 8.53720 | 11.38430 | -0.9956 | -0.9968 | 3.8098 | 0.4724 | 0.9871 | 0.8649 | |
| MDA-MB-134-VI | HR+ | Luminal | Taxol | TUBB | TUBB | 10077.002 | uM | 0.04465 | 0.05505 | -0.1204 | -0.0491 | 0.4472 | 0.5176 | 0.8533 | 0.4343 | |
| MDA-MB-134-VI | HR+ | Luminal | Taxol | TUBB | TUBB | 10265.002 | uM | 0.00646 | 0.00934 | -0.3046 | -0.2811 | 1.2076 | 0.8329 | 0.9093 | 0.3365 | |
| MDA-MB-134-VI | HR+ | Luminal | Taxol | TUBB | TUBB | 7876.002 | uM | 0.00920 | 0.01067 | -0.2958 | -0.2723 | 2.9480 | 0.7980 | 0.9954 | 1.1036 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 12206.159 | uM | 1.54950 | 1.88270 | -0.3107 | -0.3269 | 2.5829 | 0.3663 | 0.9593 | 1.0742 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10998.152 | uM | 1.57890 | 2.19730 | -0.3529 | -0.3586 | 1.6359 | 0.2994 | 0.9858 | 0.8517 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10519.14 | uM | 1.75640 | 1.85440 | -0.2549 | -0.1560 | 5.0000 | 0.2456 | 0.9880 | 1.0269 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10998.135 | uM | inf | inf | 0.4193 | 0.4193 | 0.0000 | 0.1594 | 0.3301 | 0.5194 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10519.135 | uM | inf | 37.24420 | 0.5289 | 0.5281 | 4.9611 | 0.0352 | 0.9439 | 0.8926 | |
| MDA-MB-134-VI | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 12206.135 | uM | inf | 27.55690 | 0.5920 | 0.5918 | 4.9999 | 0.0444 | 0.9779 | 0.9865 |