Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10998.144 | uM | 0.12878 | 3.20740 | -0.9804 | -1.0000 | 0.3417 | 0.6578 | 0.8701 | 0.8153 | |
| MDA-MB-134-VI | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 12206.144 | uM | 0.03827 | 8.72280 | -0.4314 | -1.0000 | 0.2024 | 0.6778 | 0.9122 | 0.9811 | |
| MDA-MB-134-VI | HR+ | Luminal | Topotecan | TOP1 | TOP | 10077.121 | uM | 0.12958 | 0.67348 | -0.8739 | -0.9510 | 0.6464 | 0.8008 | 0.9692 | 0.4875 | |
| MDA-MB-134-VI | HR+ | Luminal | Topotecan | TOP1 | TOP | 7876.007 | uM | 0.10293 | 0.75762 | -0.4533 | -0.6513 | 0.4178 | 0.6571 | 0.9747 | 1.0246 | |
| MDA-MB-134-VI | HR+ | Luminal | Topotecan | TOP1 | TOP | 7877.007 | uM | 0.00865 | 0.07627 | -0.8458 | -0.9029 | 0.4739 | 1.0580 | 0.9853 | 0.5977 | |
| MDA-MB-134-VI | HR+ | Luminal | Torkinib | 15355.211 | uM | 0.00026 | 0.00531 | -0.8198 | -0.8282 | 0.3225 | 1.2019 | 0.9869 | 1.0584 | |||
| MDA-MB-134-VI | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12206.16 | uM | 0.59013 | 9.04520 | -0.3449 | -1.0000 | 0.4025 | 0.3712 | 0.9459 | 0.9874 | |
| MDA-MB-134-VI | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10998.15 | uM | 0.75476 | 6.05740 | -0.0157 | -0.5235 | 0.3440 | 0.3452 | 0.9643 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10519.138 | uM | 1.92620 | 22.51750 | -0.3058 | -1.0000 | 0.4468 | 0.3797 | 0.9895 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | TPCA-1 | IKK | NFKB | 10519.1 | uM | 28.88770 | 64.81310 | 0.1813 | -0.3290 | 0.6257 | 0.1749 | 0.9115 | 1.0071 | |
| MDA-MB-134-VI | HR+ | Luminal | TPCA-1 | IKK | NFKB | 10419.093 | uM | 3.36240 | 2.69790 | 0.2245 | 0.3337 | 5.0000 | 0.1866 | 0.9331 | 0.5719 | |
| MDA-MB-134-VI | HR+ | Luminal | Trametinib | MEK | MAPK | 7877.05 | uM | 0.00838 | 0.01740 | -0.5316 | -0.5391 | 1.0002 | 0.8197 | 0.9799 | 0.5502 | |
| MDA-MB-134-VI | HR+ | Luminal | Trametinib | MEK | MAPK | 7876.036 | uM | 0.02479 | 0.03181 | -0.1368 | -0.1023 | 0.7472 | 0.5224 | 0.9899 | 0.8885 | |
| MDA-MB-134-VI | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 10077.026 | uM | 7.0350 | 7.93710 | 0.4622 | -0.4084 | 4.9480 | -0.0133 | 0.9348 | 0.3999 | |
| MDA-MB-134-VI | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 10419.065 | uM | 8.59820 | 11.89210 | -0.9567 | -0.7424 | 2.8064 | 0.8183 | 0.9774 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7494.065 | uM | 3.18730 | 8.28320 | -0.9774 | -0.9161 | 1.0901 | 0.9686 | 0.9832 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | Triciribine | AKT | AKT | 7494.074 | uM | 0.43155 | 0.25258 | 0.2066 | 0.1165 | 0.4950 | 0.3473 | 0.9907 | 0.6767 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 12206.143 | uM | 507.36750 | 1000.00000 | -0.9356 | -0.6985 | 1.2884 | 0.3310 | 0.9404 | 1.0676 | |
| MDA-MB-134-VI | HR+ | Luminal | Valproic acid | HDAC | HDAC | 10998.143 | uM | 478.31690 | 1000.00000 | -0.9978 | -0.9105 | 1.4062 | 0.4483 | 0.9754 | 0.5976 | |
| MDA-MB-134-VI | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7876.042 | uM | 0.03332 | 0.03940 | -0.9030 | -0.3271 | 3.0038 | 0.7241 | 0.8621 | 1.0958 | |
| MDA-MB-134-VI | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7877.042 | uM | 0.00423 | 0.00521 | -0.9988 | -0.7895 | 4.5360 | 1.2744 | 0.9640 | 0.3414 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 10419.065 | uM | 35.57540 | 66.01640 | -0.7437 | -0.6450 | 1.3401 | 0.7242 | 0.9857 | 0.7359 | |
| MDA-MB-134-VI | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7494.065 | uM | 33.96610 | 84.09910 | -0.8999 | -0.8103 | 1.0626 | 0.7825 | 0.9875 | 0.6688 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10998.151 | uM | 0.59196 | 0.63270 | 0.0499 | -0.0948 | 2.6094 | 0.4574 | 0.9332 | 0.6986 | |
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 12206.157 | uM | 0.76755 | 1.04930 | -0.3319 | -0.3141 | 1.5590 | 0.5114 | 0.9889 | 0.9766 |