Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-134-VI | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10519.139 | uM | 1.26790 | 1.37170 | -0.0861 | -0.0865 | 2.0272 | 0.4160 | 0.9889 | 1.0177 | |
| MDA-MB-134-VI | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14264.189 | uM | 0.67693 | 0.82867 | -0.9127 | -0.8745 | 5.0000 | 0.6538 | 0.9941 | 1.2647 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 10519.138 | uM | inf | inf | 0.6714 | 0.6714 | 0.0000 | 0.1433 | 0.4519 | 1.0592 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 10998.15 | uM | inf | 0.4260 | 0.5290 | 0.5770 | 2.1068 | 0.1652 | 0.8990 | 0.8386 | |
| MDA-MB-134-VI | HR+ | Luminal | ZM-447439 | AURK | AURK | 12206.16 | uM | 1.49790 | 0.65874 | 0.3607 | 0.3822 | 1.7595 | 0.2802 | 0.9203 | 0.9874 | |
| MDA-MB-157 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7882.016 | uM | inf | inf | 0.7087 | 0.7087 | 0.0000 | 0.1209 | 0.5649 | 1.0905 | ||
| MDA-MB-157 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7878.016 | uM | inf | 15.01940 | 0.7927 | 0.8386 | 4.9792 | 0.0160 | 0.7114 | 1.4153 | ||
| MDA-MB-157 | TNBC | Basal B | 2-deoxyglucose | 12632.177 | uM | 919.10260 | 1000.00000 | -0.0562 | -0.1129 | 2.4132 | 0.0959 | 0.990 | 0.6753 | |||
| MDA-MB-157 | TNBC | Basal B | 5-DFUR | TYMS | TYMS | 12594.143 | uM | 150.18210 | 217.4130 | 0.1345 | -0.0799 | 0.4008 | 0.3069 | 0.9481 | 1.2787 | |
| MDA-MB-157 | TNBC | Basal B | 5-FU | TYMS | TYMS | 7879.017 | uM | 915.45150 | 1000.00000 | 0.0233 | -0.0364 | 0.7947 | 0.2302 | 0.9921 | 1.7754 | |
| MDA-MB-157 | TNBC | Basal B | Afatinib | EGFR/HER2 | ErbB | 12594.165 | uM | 2.59690 | 3.54610 | -0.9272 | -0.9249 | 3.3616 | 0.4068 | 0.9988 | 1.4798 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7496.066 | uM | inf | inf | 0.9520 | 0.9520 | 0.0000 | -0.0297 | -0.4278 | 1.1616 | |
| MDA-MB-157 | TNBC | Basal B | AG1024 | IGF1R | RTK | 7498.066 | uM | inf | inf | 0.9884 | 0.9884 | 0.0000 | -0.0181 | -0.3947 | 1.0752 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7878.016 | uM | inf | inf | 0.8526 | 0.8526 | 0.0000 | 0.0384 | 0.5269 | 1.4153 | |
| MDA-MB-157 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7882.016 | uM | 11.29980 | 11.78750 | -0.2448 | -0.1176 | 5.0000 | 0.2809 | 0.9469 | 1.0905 | |
| MDA-MB-157 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 12594.165 | uM | inf | inf | 1.0438 | 1.0438 | 0.0000 | -0.0174 | -0.2249 | 1.4798 | |
| MDA-MB-157 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7496.072 | uM | 37.29220 | 50.83810 | -0.9770 | -1.0000 | 3.5455 | 0.2165 | 0.9897 | 0.8808 | |
| MDA-MB-157 | TNBC | Basal B | Baicalein | Lipoxygenase | Metabolism | 7498.073 | uM | 64.68120 | 126.11270 | -0.2294 | -1.0000 | 1.6454 | 0.1232 | 0.9912 | 1.1962 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7496.074 | uM | 0.05608 | 0.11046 | -0.9513 | -0.9648 | 1.5858 | 1.1437 | 0.9961 | 1.3504 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7496.074 | uM | 0.05608 | 0.11046 | -0.9513 | -0.9648 | 1.5858 | 1.1437 | 0.9961 | 1.3504 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7498.074 | uM | 0.02939 | 0.04654 | -0.9813 | -0.9617 | 2.3346 | 1.2452 | 0.9984 | 1.0877 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7498.074 | uM | 0.02939 | 0.04654 | -0.9813 | -0.9617 | 2.3346 | 1.2452 | 0.9984 | 1.0877 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7495.074 | uM | 0.03404 | 0.05334 | -0.9887 | -0.9742 | 2.4079 | 1.2336 | 0.9985 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 7495.074 | uM | 0.03404 | 0.05334 | -0.9887 | -0.9742 | 2.4079 | 1.2336 | 0.9985 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14841.203 | uM | 0.00621 | 0.01122 | -0.9733 | -0.9729 | 1.8265 | 1.3380 | 0.9989 | 1.0330 |