Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-157 | TNBC | Basal B | Bortezomib | Proteasome | Proteasome | 14841.203 | uM | 0.00621 | 0.01122 | -0.9733 | -0.9729 | 1.8265 | 1.3380 | 0.9989 | 1.0330 | |
| MDA-MB-157 | TNBC | Basal B | Bosutinib | Src | nRTK | 12594.17 | uM | 1.33540 | 1.58460 | -0.6767 | -0.6764 | 4.9987 | 0.3707 | 0.9979 | 1.2180 | |
| MDA-MB-157 | TNBC | Basal B | Bromopyruvic acid | Hexokinase II | Metabolism | 12632.177 | uM | 0.04978 | 0.0620 | -0.9999 | -0.9991 | 5.0000 | 0.9410 | 0.9993 | 0.6753 | |
| MDA-MB-157 | TNBC | Basal B | Carboplatin | DNA cross-linker | DNA cross-linker | 10093.021 | uM | 32.91210 | 101.35890 | -0.9939 | -1.0000 | 0.9767 | 0.5411 | 0.9068 | 0.9172 | |
| MDA-MB-157 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7879.018 | uM | inf | inf | 0.9952 | 0.9952 | 0.0000 | -0.0245 | -1.0109 | 1.7910 | |
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 10093.034 | uM | 45.62710 | 523.32560 | -0.9855 | -1.0000 | 0.4503 | 0.4906 | 0.7834 | 0.9732 | ||
| MDA-MB-157 | TNBC | Basal B | CGC-11047 | Polyamine analogue | 7879.018 | uM | 561.54250 | 1000.00000 | -0.8596 | -0.7465 | 1.5830 | 0.3144 | 0.7962 | 1.7910 | ||
| MDA-MB-157 | TNBC | Basal B | Chloroquine | 12632.177 | uM | 1.67050 | 3.57270 | -0.9971 | -1.0000 | 1.4452 | 0.4610 | 0.9970 | 0.6753 | |||
| MDA-MB-157 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10093.021 | uM | 0.91384 | 16.27850 | -0.9838 | -1.0000 | 0.3815 | 0.5822 | 0.6802 | 0.9172 | |
| MDA-MB-157 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 7879.017 | uM | 19.36470 | 39.12250 | -0.8954 | -1.0000 | 1.5622 | 0.3132 | 0.9896 | 1.7754 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 10093.034 | uM | 3.05240 | 11.29610 | -0.9078 | -1.0000 | 0.8396 | 0.3102 | 0.9433 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7879.077 | uM | 28.44980 | 47.69040 | -0.5525 | -1.0000 | 2.1267 | 0.1493 | 0.9818 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Dactolisib | PI3K | PI3K | 12594.155 | uM | 0.35404 | 0.21862 | 0.4574 | 0.4551 | 5.0000 | 0.2267 | 0.9613 | 1.3872 | |
| MDA-MB-157 | TNBC | Basal B | Dichloroacetate | PDK | PDK | 12632.176 | uM | inf | inf | 0.8532 | 0.8532 | 0.0000 | 0.0329 | 0.0301 | 0.8098 | |
| MDA-MB-157 | TNBC | Basal B | Disulfiram | Proteasome | Proteasome | 12632.174 | uM | 0.06398 | 0.29356 | -0.9906 | -0.8755 | 0.6642 | 0.7679 | 0.9097 | 0.8563 | |
| MDA-MB-157 | TNBC | Basal B | Docetaxel | TUBB | TUBB | 10093.002 | uM | 0.00221 | 0.00265 | -0.7874 | -0.7345 | 4.9987 | 1.1147 | 0.9951 | 0.9296 | |
| MDA-MB-157 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 10093.034 | uM | 0.00588 | 0.06554 | -0.9994 | -1.0000 | 0.4558 | 1.1551 | 0.8879 | 0.9732 | |
| MDA-MB-157 | TNBC | Basal B | Doxorubicin | TOP2 | TOP | 7879.077 | uM | 0.39484 | 0.83175 | -0.9047 | -0.8497 | 1.3328 | 0.6877 | 0.9917 | 1.8534 | |
| MDA-MB-157 | TNBC | Basal B | Epirubicin | TOP2 | TOP | 7879.017 | uM | 0.38116 | 0.41730 | -0.7909 | -0.2865 | 5.0000 | 0.6761 | 0.6129 | 1.7754 | |
| MDA-MB-157 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7498.091 | uM | inf | 27.1530 | 0.7131 | 0.7029 | 3.6973 | -0.0137 | 0.8545 | 1.1445 | |
| MDA-MB-157 | TNBC | Basal B | Erlotinib | EGFR | ErbB | 7496.092 | uM | inf | 9.44070 | 0.5633 | 0.5623 | 4.7987 | 0.0291 | 0.9641 | 0.9861 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7495.074 | uM | 1.04210 | 7.71570 | -0.8109 | -1.0000 | 0.5488 | 0.6466 | 0.9249 | 1.1729 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7498.074 | uM | 1.27320 | 6.94970 | -0.7977 | -1.0000 | 0.6473 | 0.6374 | 0.9526 | 1.0877 | |
| MDA-MB-157 | TNBC | Basal B | Etoposide | TOP2 | TOP | 7496.074 | uM | 0.86659 | 8.47420 | -0.7156 | -1.0000 | 0.4818 | 0.6452 | 0.9646 | 1.3504 | |
| MDA-MB-157 | TNBC | Basal B | Everolimus | MTOR | MTOR | 12594.164 | uM | inf | 34.95910 | 0.5722 | 0.2744 | 0.1777 | 0.2039 | 0.8794 | 1.2567 |