Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | HR+ | Luminal | Taxol | TUBB | TUBB | 7875.002 | uM | 0.01223 | 0.01001 | 0.0795 | 0.1374 | 1.6028 | 0.5354 | 0.9916 | 1.8262 | |
| MCF7 | HR+ | Luminal | Taxol | TUBB | TUBB | 9583.002 | uM | 0.01556 | 0.01348 | 0.0751 | 0.1066 | 1.6686 | 0.5438 | 0.9948 | 1.2590 | |
| MCF7 | HR+ | Luminal | TCS 2312 | CHK1 | CHK | 10997.152 | uM | 1.08980 | 2.07370 | -0.8302 | -0.8745 | 1.5717 | 0.4343 | 0.9932 | 1.3917 | |
| MCF7 | HR+ | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10997.135 | uM | inf | inf | 0.6626 | 0.6626 | 0.0000 | 0.1138 | 0.4054 | 0.6582 | |
| MCF7 | HR+ | Luminal | Temsirolimus | MTOR | MTOR | 10997.144 | uM | 1.47690 | 14.93110 | -0.9097 | -1.0000 | 0.4749 | 0.4562 | 0.8489 | 1.2750 | |
| MCF7 | HR+ | Luminal | Topotecan | TOP1 | TOP | 9583.121 | uM | 1.14360 | 2.03460 | -0.1948 | -0.2543 | 0.7136 | 0.3894 | 0.9771 | 1.0648 | |
| MCF7 | HR+ | Luminal | Topotecan | TOP1 | TOP | 7875.007 | uM | 1.67650 | 2.66390 | -0.5030 | -0.4769 | 1.4463 | 0.4417 | 0.9888 | 1.4906 | |
| MCF7 | HR+ | Luminal | Torkinib | 15394.211 | uM | 0.00006 | 0.00015 | -0.2414 | -0.2040 | 0.3606 | 1.0163 | 0.9695 | 1.8299 | |||
| MCF7 | HR+ | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10997.15 | uM | 7.12150 | 132.2610 | 0.1476 | -1.0000 | 0.3760 | 0.2151 | 0.8802 | 1.4218 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 7874.05 | uM | inf | inf | 0.9256 | 0.9256 | 0.0000 | 0.0249 | 0.5118 | 1.5863 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 10073.012 | uM | inf | 0.00899 | 0.7975 | 0.8139 | 0.7980 | 0.1192 | 0.6523 | 0.5734 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 9583.012 | uM | inf | 999.99990 | 0.7666 | 0.0211 | 0.3357 | 0.0475 | 0.6670 | 1.1482 | |
| MCF7 | HR+ | Luminal | Trametinib | MEK | MAPK | 7875.012 | uM | inf | 0.06488 | 0.8818 | 0.8930 | 1.5563 | 0.0471 | 0.7978 | 1.7071 | |
| MCF7 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 9583.026 | uM | 28.56660 | 99.86730 | 0.8051 | -0.9208 | 0.8344 | 0.0378 | 0.6951 | 1.2731 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7492.065 | uM | 9.64560 | 13.950 | -0.5549 | -0.5539 | 2.0207 | 0.7416 | 0.9919 | 1.6050 | |
| MCF7 | HR+ | Luminal | Trichostatin A | HDAC | HDAC | 7493.065 | uM | 5.27770 | 8.96730 | -0.7744 | -0.7779 | 1.7703 | 0.8796 | 0.9977 | 1.2680 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 7492.074 | uM | 0.27441 | 0.34225 | -0.0961 | -0.1118 | 0.9138 | 0.4035 | 0.9951 | 1.4222 | |
| MCF7 | HR+ | Luminal | Triciribine | AKT | AKT | 7493.074 | uM | 0.12436 | 0.26451 | -0.3977 | -0.4199 | 0.8079 | 0.5445 | 0.9983 | 1.1549 | |
| MCF7 | HR+ | Luminal | Valproic acid | HDAC | HDAC | 10997.143 | uM | 708.93120 | 1000.00000 | -0.8091 | -0.3585 | 1.5715 | 0.2197 | 0.8268 | 0.6416 | |
| MCF7 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7874.018 | uM | 0.02477 | 0.83858 | -0.8729 | -1.0000 | 0.3119 | 0.6919 | 0.8440 | 1.6506 | |
| MCF7 | HR+ | Luminal | Vinorelbine | TUBB | TUBB | 7875.018 | uM | 0.04060 | 1.1320 | -0.8800 | -1.0000 | 0.3301 | 0.6619 | 0.8693 | 1.6565 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7493.065 | uM | 56.83240 | 120.4940 | -0.8559 | -0.8255 | 1.2973 | 0.7169 | 0.9961 | 1.2680 | |
| MCF7 | HR+ | Luminal | Vorinostat | HDAC | HDAC | 7492.065 | uM | 78.6430 | 148.7980 | -0.6258 | -0.6031 | 1.2409 | 0.6073 | 0.9973 | 1.6050 | |
| MCF7 | HR+ | Luminal | XRP44X | ELK3 | MAPK | 10997.151 | uM | 0.42440 | 0.37088 | 0.3135 | 0.2452 | 5.0000 | 0.3459 | 0.9693 | 1.3229 | |
| MCF7 | HR+ | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14640.189 | uM | 1.70390 | 2.83780 | -0.8158 | -0.8323 | 1.9211 | 0.4794 | 0.9971 | 1.5721 |