Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 10817.151 | uM | 0.37684 | 0.14924 | 0.3567 | 0.3698 | 1.4529 | 0.2738 | 0.9944 | 1.4848 | |
| MCF12A | NM | Basal B | IKK16 | IKK | NFKB | 7490.093 | uM | 3.43830 | 4.18620 | -0.7142 | -0.7151 | 4.5114 | 0.3647 | 0.9985 | 2.3707 | |
| MCF12A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7490.091 | uM | 53.81120 | 77.89240 | -0.6995 | -0.7142 | 2.3989 | 0.2886 | 0.9978 | 2.5547 | |
| MCF12A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7489.09 | uM | 31.0410 | 41.980 | -0.8584 | -0.8585 | 3.3109 | 0.3463 | 0.9985 | 1.9790 | |
| MCF12A | NM | Basal B | Ispinesib | KSP | Kinesin | 7490.067 | uM | 0.14468 | 2.57510 | -0.6794 | -1.0000 | 0.3816 | 0.4977 | 0.8901 | 2.6472 | |
| MCF12A | NM | Basal B | Ispinesib | KSP | Kinesin | 7489.067 | uM | 0.10172 | 0.70953 | -0.9138 | -1.0000 | 0.5656 | 0.6199 | 0.9358 | 1.7603 | |
| MCF12A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7490.095 | uM | 0.01583 | 0.20763 | -0.7211 | -0.9087 | 0.4024 | 0.7905 | 0.9567 | 2.7242 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 12365.168 | uM | 87.14890 | 200.63390 | -0.0145 | -1.0000 | 1.3175 | 0.1430 | 0.8820 | 2.1914 | |
| MCF12A | NM | Basal B | JNK-IN-5A | JNK | JNK | 10817.144 | uM | 1.52950 | 1.63410 | -0.2935 | -0.1960 | 5.0000 | 0.3934 | 0.9887 | 1.4640 | |
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 12365.166 | uM | 19.65440 | 49.33380 | 0.2431 | -0.9485 | 1.1557 | 0.0557 | 0.9856 | 1.8961 | |
| MCF12A | NM | Basal B | L-779450 | BRAF | MAPK | 10817.149 | uM | 7.84630 | 9.93210 | 0.0505 | -0.1663 | 1.2177 | 0.1275 | 0.9882 | 1.4656 | |
| MCF12A | NM | Basal B | LBH589 | HDAC | HDAC | 12365.167 | uM | 0.22436 | 0.57019 | -0.6338 | -0.6704 | 0.9118 | 0.5236 | 0.9989 | 2.0273 | |
| MCF12A | NM | Basal B | LBH589 | HDAC | HDAC | 10817.154 | uM | 0.96290 | 1.2080 | -0.8736 | -0.8706 | 4.4460 | 0.4940 | 0.9989 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 10817.154 | uM | 0.57634 | 1.04690 | -0.6076 | -0.5571 | 1.2543 | 0.3966 | 0.9910 | 1.4551 | |
| MCF12A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12365.167 | uM | 0.49777 | 2.23750 | -0.7263 | -0.9507 | 0.7087 | 0.4221 | 0.9949 | 2.0273 | |
| MCF12A | NM | Basal B | Mebendazole | 12949.174 | uM | 2.69550 | 4.30780 | 0.0553 | -0.1473 | 0.5507 | 0.2817 | 0.9795 | 1.9016 | |||
| MCF12A | NM | Basal B | Methotrexate | DHFR | Metabolism | 7489.084 | uM | inf | 0.05529 | 0.6914 | 0.7635 | 4.9999 | 0.1630 | 0.8755 | 2.0279 | |
| MCF12A | NM | Basal B | Methotrexate | DHFR | Metabolism | 7490.085 | uM | 0.28874 | 0.09371 | 0.3581 | 0.3802 | 1.2695 | 0.3975 | 0.9816 | 2.5778 | |
| MCF12A | NM | Basal B | Methylglyoxal | 13508.184 | uM | 576.52490 | 995.81850 | -0.8032 | -0.7829 | 1.7240 | 0.5701 | 0.9916 | 2.2235 | |||
| MCF12A | NM | Basal B | MG-132 | Proteasome | Proteasome | 14164.189 | uM | 0.02152 | 0.03005 | -0.9933 | -0.5632 | 2.2599 | 1.0599 | 0.6767 | 0.7884 | |
| MCF12A | NM | Basal B | MG-132 | Proteasome | Proteasome | 14164.189 | uM | 0.02152 | 0.03005 | -0.9933 | -0.5632 | 2.2599 | 1.0599 | 0.6767 | 0.7884 | |
| MCF12A | NM | Basal B | MG-132 | Proteasome | Proteasome | 12365.17 | uM | 0.03571 | 0.07223 | -0.7143 | -0.6743 | 1.2123 | 0.8940 | 0.9883 | 2.2930 | |
| MCF12A | NM | Basal B | MG-132 | Proteasome | Proteasome | 12365.17 | uM | 0.03571 | 0.07223 | -0.7143 | -0.6743 | 1.2123 | 0.8940 | 0.9883 | 2.2930 | |
| MCF12A | NM | Basal B | MG-132 | Proteasome | Proteasome | 10817.145 | uM | 0.05007 | 0.07304 | -0.8603 | -0.7796 | 2.4893 | 0.9493 | 0.9893 | 1.5564 | |
| MCF12A | NM | Basal B | MG-132 | Proteasome | Proteasome | 10817.145 | uM | 0.05007 | 0.07304 | -0.8603 | -0.7796 | 2.4893 | 0.9493 | 0.9893 | 1.5564 |