Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
MCF12A	NM	Basal B	Fascaplysin	CDK4	CDK	7490.085	uM	0.49583	0.95134	-0.6925	-0.7396	1.3933	0.4915	0.9979	2.5778
MCF12A	NM	Basal B	Fascaplysin	CDK4	CDK	7489.084	uM	0.33974	0.49837	-0.8411	-0.8185	2.5307	0.5907	0.9994	2.0279
MCF12A	NM	Basal B	FR180204	ERK1/2	MAPK	12365.166	uM	124.07930	112.83180	0.7128	0.1891	4.9999	-0.0062	0.8958	1.8961
MCF12A	NM	Basal B	FR180204	ERK1/2	MAPK	10817.149	uM	inf	10.47840	0.6932	0.6909	4.2019	0.0379	0.9131	1.4656
MCF12A	NM	Basal B	FTase Inhibitor I	Ftase	MAPK	12365.167	uM	inf	inf	1.0500	1.0500	0.0000	-0.0137	-0.2379	2.0273
MCF12A	NM	Basal B	FTase Inhibitor I	Ftase	MAPK	10817.154	uM	inf	inf	1.0326	1.0326	0.0000	-0.0111	-0.1985	1.4551
MCF12A	NM	Basal B	Gefitinib	EGFR	ErbB	10061.049	uM	0.87261	3.62350	-0.8055	-1.0000	0.7717	0.3691	0.9583	1.7845
MCF12A	NM	Basal B	Gefitinib	EGFR	ErbB	7491.016	uM	0.11698	0.26482	-0.8932	-0.8426	1.2089	0.7582	0.9671	0.6625
MCF12A	NM	Basal B	Gefitinib	EGFR	ErbB	7873.016	uM	0.82101	1.23090	-0.3210	-0.2758	1.0846	0.3085	0.9804	2.1516
MCF12A	NM	Basal B	Geldanamycin	HSP90	HSP90	7873.04	uM	0.01582	0.01976	-0.5192	-0.4643	2.9510	0.9705	0.9971	2.1738
MCF12A	NM	Basal B	Geldanamycin	HSP90	HSP90	10061.049	uM	0.02306	0.03084	-0.5939	-0.5800	2.6507	0.9816	0.9988	1.7845
MCF12A	NM	Basal B	Gemcitabine	DNA replication	DNA replication	10061.12	uM	0.28867	0.25213	0.0671	0.0377	0.5785	0.4089	0.9672	2.0669
MCF12A	NM	Basal B	Gemcitabine	DNA replication	DNA replication	7873.011	uM	0.03446	0.06143	-0.3727	-0.2947	0.8016	0.7607	0.9714	2.0810
MCF12A	NM	Basal B	Glycyl-H-1152	ROCK2		12365.169	uM	inf	2.76580	0.7240	0.7388	5.0000	0.0520	0.9488	2.1831
MCF12A	NM	Basal B	Glycyl-H-1152	ROCK2		10817.15	uM	inf	2.06940	0.5134	0.5168	4.9958	0.1013	0.9788	1.3689
MCF12A	NM	Basal B	GM6001	MMP	MMP	7490.096	uM	inf	inf	0.9454	0.9454	0.0000	0.0235	0.2665	2.5767
MCF12A	NM	Basal B	GSK1070916	AURK	AURK	10061.001	uM	7.05180	18.47620	-0.3544	-1.0000	1.1406	0.2085	0.9378	1.7406
MCF12A	NM	Basal B	GSK1838705A	IGF1R	RTK	7490.091	uM	5.73470	5.84610	-0.5417	-0.0505	5.0000	0.3368	0.7023	2.5547
MCF12A	NM	Basal B	GSK1838705A	IGF1R	RTK	7489.09	uM	1.2790	1.18790	0.0018	0.0881	2.6230	0.3236	0.9743	1.9790
MCF12A	NM	Basal B	GSK461364	PLK1	PLK	10061.001	uM	1.47950	7.65830	-0.8558	-1.0000	0.6682	0.3189	0.8112	1.7406
MCF12A	NM	Basal B	GSK923295	CENPE	Kinesin	10061.001	uM	2.01520	9.19330	-0.7674	-1.0000	0.7238	0.3226	0.8034	1.7406
MCF12A	NM	Basal B	GW-5074	CRAF	MAPK	7490.088	uM	inf	11.57980	0.6441	0.6321	3.1892	0.0374	0.9776	2.5415
MCF12A	NM	Basal B	Ibandronate	FDPS		12365.143	uM	172.18210	247.57150	-0.0273	-0.2106	0.9681	0.2239	0.9728	2.3865
MCF12A	NM	Basal B	Ibandronate	FDPS		10817.143	uM	286.68820	557.64170	-0.2466	-0.6217	1.2144	0.1665	0.9914	1.5734
MCF12A	NM	Basal B	ICRF-193	TOP2	TOP	12365.157	uM	inf	0.07339	0.5291	0.5377	2.2021	0.2386	0.9924	2.2468

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)