Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
MCF 10A	NM	Basal B	PS-1145	IKK	NFKB	7485.065	uM	inf	inf	1.0111	1.0111	0.0000	-0.0094	-0.0465	3.5869
MCF 10A	NM	Basal B	Purvalanol A	CDK1	CDK	7485.067	uM	inf	1000.00000	0.8943	0.7817	0.1323	0.0582	0.6910	3.7597
MCF 10A	NM	Basal B	Purvalanol A	CDK1	CDK	7484.067	uM	128.58530	74.97640	0.4507	0.2276	1.1261	0.0924	0.920	2.7060
MCF 10A	NM	Basal B	Purvalanol A	CDK1	CDK	7483.067	uM	14.92040	12.96040	0.2548	0.2527	5.0000	0.1513	0.9938	3.2893
MCF 10A	NM	Basal B	QNZ	NFkB	NFKB	7485.096	uM	inf	0.01357	0.7418	0.7933	4.9979	0.1268	0.870	3.6265
MCF 10A	NM	Basal B	Ribavirin			15392.211	uM	inf	1000.00000	0.6244	0.0123	0.2385	0.1289	0.6395	2.9667
MCF 10A	NM	Basal B	SB-3CT	MMP2/9	MMP	11056.144	uM	330.32130	72.33220	0.6303	0.3410	0.7545	0.0585	0.9601	2.8424
MCF 10A	NM	Basal B	Selumetinib	MEK	MAPK	11056.155	uM	0.58108	0.20047	0.2591	0.2625	0.6997	0.3086	0.9843	2.9269
MCF 10A	NM	Basal B	Sigma A6730	AKT	AKT	11056.158	uM	7.65320	19.14650	-0.6765	-1.0000	1.1981	0.2305	0.9942	2.7355
MCF 10A	NM	Basal B	Sirolimus	MTOR	MTOR	7868.068	uM	inf	inf	-0.3252	-0.3252	0.0000	0.4691	0.3332	2.1801
MCF 10A	NM	Basal B	Sirolimus	MTOR	MTOR	7484.068	uM	8.15170	9.87540	0.1105	-0.0202	0.2065	0.3579	0.6480	2.6661
MCF 10A	NM	Basal B	Sirolimus	MTOR	MTOR	7483.069	uM	inf	0.03335	0.6664	0.6993	0.7330	0.1552	0.9732	3.1344
MCF 10A	NM	Basal B	Sorafenib	PDGFR/VEGFR/KIT/FLT3	RTK	7485.085	uM	inf	inf	0.6039	0.6039	0.0000	0.0739	0.1924	3.6369
MCF 10A	NM	Basal B	Sorafenib	PDGFR/VEGFR/KIT/FLT3	RTK	7484.084	uM	336.95260	505.51750	-0.7327	-1.0000	2.7083	0.2050	0.8765	2.6217
MCF 10A	NM	Basal B	Sorafenib	PDGFR/VEGFR/KIT/FLT3	RTK	7483.084	uM	inf	57.7450	0.5637	0.5667	3.1797	0.1071	0.9452	3.2830
MCF 10A	NM	Basal B	Sunitinib	PDGFR/VEGFR/KIT/FLT3	RTK	7485.067	uM	5.35070	8.22830	-0.4965	-0.5259	1.6702	0.3809	0.9972	3.7597
MCF 10A	NM	Basal B	Sunitinib	PDGFR/VEGFR/KIT/FLT3	RTK	7484.067	uM	6.64290	10.24480	-0.7590	-0.7701	2.1519	0.4047	0.9976	2.7060
MCF 10A	NM	Basal B	Sunitinib	PDGFR/VEGFR/KIT/FLT3	RTK	7483.067	uM	7.35150	12.33760	-0.7295	-0.7449	1.7619	0.3474	0.9991	3.2893
MCF 10A	NM	Basal B	TAPI-0	TACE/Collagenase		7485.096	uM	inf	0.60765	0.8642	0.8608	0.8411	0.0408	0.8798	3.6265
MCF 10A	NM	Basal B	Taxol	TUBB	TUBB	9551.002	uM	0.00925	0.01162	-0.3111	-0.2584	1.8251	0.7662	0.9937	2.5642
MCF 10A	NM	Basal B	Taxol	TUBB	TUBB	7867.002	uM	0.01015	0.01064	-0.0842	-0.0401	1.6469	0.6431	0.9952	2.3763
MCF 10A	NM	Basal B	Taxol	TUBB	TUBB	12944.002	uM	0.01225	0.01269	-0.0477	-0.0345	1.8720	0.6298	0.9966	2.6856
MCF 10A	NM	Basal B	Taxol	TUBB	TUBB	7870.002	uM	0.01173	0.01233	-0.0690	-0.0403	1.5367	0.6332	0.9986	2.4447
MCF 10A	NM	Basal B	TCS 2312	CHK1	CHK	11056.152	uM	1.37080	1.66080	-0.4430	-0.4364	3.2697	0.3155	0.9989	2.9748
MCF 10A	NM	Basal B	TCS PIM-1 1	Pim kinase	PIM	11056.135	uM	inf	15.68780	0.6346	0.6346	4.2624	0.0817	0.9274	2.9533

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)