Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | MG-132 | Proteasome | Proteasome | 11056.145 | uM | 0.06959 | 0.09013 | -0.6701 | -0.6179 | 3.1115 | 0.8197 | 0.9978 | 2.8383 | |
| MCF 10A | NM | Basal B | MG-132 | Proteasome | Proteasome | 11056.145 | uM | 0.06959 | 0.09013 | -0.6701 | -0.6179 | 3.1115 | 0.8197 | 0.9978 | 2.8383 | |
| MCF 10A | NM | Basal B | Pevonedistat | NAE1 | NAE1 | 11056.135 | uM | 1.27060 | 1.16760 | 0.1340 | 0.0238 | 0.5776 | 0.3180 | 0.9873 | 2.9533 | |
| MCF 10A | NM | Basal B | Nelfinavir | 12944.174 | uM | 13.84570 | 22.41740 | -0.4231 | -1.0000 | 2.2799 | 0.1120 | 0.9965 | 2.7985 | |||
| MCF 10A | NM | Basal B | Nilotinib | ABL | nRTK | 11056.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0366 | -2.6666 | 2.8383 | |
| MCF 10A | NM | Basal B | NSC 663284 | CDC25 | CDC | 11056.152 | uM | 2.5150 | 3.6580 | -0.5954 | -0.5991 | 2.1023 | 0.4848 | 0.9995 | 2.9748 | |
| MCF 10A | NM | Basal B | NU6102 | CDK1/2 | CDK | 11056.147 | uM | 9.51810 | 19.82060 | -0.7954 | -1.0000 | 1.4977 | 0.2236 | 0.9814 | 2.7832 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 7484.066 | uM | 7.17650 | 24.4860 | -0.5168 | -1.0000 | 0.8952 | 0.2642 | 0.9606 | 2.8312 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 7485.066 | uM | 15.83140 | 44.35380 | -0.2315 | -1.0000 | 1.0664 | 0.1450 | 0.9883 | 3.6205 | |
| MCF 10A | NM | Basal B | Nutlin 3a | MDM2 | MDM2 | 7483.066 | uM | 12.56260 | 7.53510 | 0.2838 | 0.2044 | 1.0282 | 0.1538 | 0.9908 | 3.2636 | |
| MCF 10A | NM | Basal B | Olomoucine II | CDK1 | CDK | 11056.147 | uM | 3.70640 | 4.88790 | -0.5848 | -0.5906 | 2.8183 | 0.3891 | 0.9981 | 2.7832 | |
| MCF 10A | NM | Basal B | Omipalisib | PI3K | PI3K | 7485.086 | uM | 0.02196 | 0.04236 | -0.2162 | -0.2393 | 0.5951 | 0.6420 | 0.9992 | 3.3609 | |
| MCF 10A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9551.011 | uM | 27.64590 | 149.24130 | -0.6193 | -1.0000 | 0.6516 | 0.3061 | 0.9092 | 2.7742 | |
| MCF 10A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7870.011 | uM | 7.16950 | 45.19430 | -0.8377 | -1.0000 | 0.5967 | 0.4661 | 0.960 | 2.1270 | |
| MCF 10A | NM | Basal B | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7867.011 | uM | 7.90780 | 53.84570 | -0.7907 | -1.0000 | 0.5727 | 0.4302 | 0.9619 | 2.3684 | |
| MCF 10A | NM | Basal B | Oxamflatin | HDAC | HDAC | 11056.147 | uM | 0.98925 | 1.89960 | -0.6755 | -0.7170 | 1.3633 | 0.4683 | 0.9983 | 2.7832 | |
| MCF 10A | NM | Basal B | PD 98059 | MEK | MAPK | 11056.152 | uM | inf | 999.74860 | 0.8064 | -0.1009 | 0.5266 | 0.0422 | 0.8157 | 2.9748 | |
| MCF 10A | NM | Basal B | PD173074 | FGFR1/3 | RTK | 7485.093 | uM | 14.25160 | 28.64420 | -0.1192 | -1.0000 | 1.5737 | 0.1087 | 0.9973 | 3.5766 | |
| MCF 10A | NM | Basal B | PD184352 | MEK | MAPK | 11056.155 | uM | 4.32740 | 75.78760 | 0.1457 | -1.0000 | 0.3837 | 0.2199 | 0.9892 | 2.9269 | |
| MCF 10A | NM | Basal B | PD184352 | MEK | MAPK | 11056.155 | uM | 4.32740 | 75.78760 | 0.1457 | -1.0000 | 0.3837 | 0.2199 | 0.9892 | 2.9269 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7484.094 | uM | inf | 0.87271 | 0.6437 | 0.6466 | 1.6780 | 0.2352 | 0.8160 | 2.6561 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7485.095 | uM | inf | 0.41233 | 0.6182 | 0.6391 | 1.3791 | 0.2561 | 0.8574 | 3.6625 | |
| MCF 10A | NM | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7483.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 2.6732 | |
| MCF 10A | NM | Basal B | PS-1145 | IKK | NFKB | 7484.065 | uM | inf | inf | 1.0207 | 1.0207 | 0.0000 | -0.0389 | -8.5103 | 2.3857 | |
| MCF 10A | NM | Basal B | PS-1145 | IKK | NFKB | 7483.065 | uM | inf | inf | 1.0028 | 1.0028 | 0.0000 | -0.0064 | -0.1890 | 3.0487 |