Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | ICRF-193 | TOP2 | TOP | 11056.151 | uM | inf | 0.04801 | 0.5349 | 0.5474 | 2.0247 | 0.2393 | 0.9850 | 3.0292 | |
| MCF 10A | NM | Basal B | IKK16 | IKK | NFKB | 7485.093 | uM | 3.30420 | 4.07620 | -0.4760 | -0.4790 | 3.2002 | 0.3287 | 0.9978 | 3.5766 | |
| MCF 10A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7484.09 | uM | 27.63420 | 39.63650 | -0.7365 | -0.7394 | 2.5167 | 0.3858 | 0.9956 | 2.6525 | |
| MCF 10A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7483.091 | uM | 48.69320 | 62.71530 | -0.5328 | -0.5357 | 2.8774 | 0.2858 | 0.9976 | 3.0465 | |
| MCF 10A | NM | Basal B | Imatinib | ABL/KIT/PDGFR | nRTK | 7485.092 | uM | 45.48520 | 59.9910 | -0.5636 | -0.5671 | 2.7388 | 0.2889 | 0.9987 | 3.6408 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 7484.067 | uM | 0.23564 | 3.81680 | -0.7056 | -1.0000 | 0.3945 | 0.4557 | 0.8684 | 2.7060 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 7483.067 | uM | 0.03317 | 0.03696 | -0.6323 | -0.1358 | 2.2198 | 0.5611 | 0.8844 | 3.2893 | |
| MCF 10A | NM | Basal B | Ispinesib | KSP | Kinesin | 7485.067 | uM | 0.14987 | 1.80190 | -0.4694 | -0.8167 | 0.3894 | 0.4872 | 0.9420 | 3.7597 | |
| MCF 10A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7484.094 | uM | 0.00437 | 0.04204 | -0.7526 | -0.8693 | 0.4448 | 1.2063 | 0.9147 | 2.6561 | |
| MCF 10A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7483.095 | uM | 0.0160 | 0.11519 | -0.8965 | -0.9405 | 0.5360 | 0.8532 | 0.9476 | 2.6732 | |
| MCF 10A | NM | Basal B | Ixabepilone | TUBB | TUBB | 7485.095 | uM | 0.02889 | 0.21398 | -0.5677 | -0.7205 | 0.4457 | 0.7050 | 0.9677 | 3.6625 | |
| MCF 10A | NM | Basal B | JNK-IN-5A | JNK | JNK | 11056.144 | uM | 19.54620 | 154.7090 | -0.0990 | -1.0000 | 0.5311 | 0.1869 | 0.7972 | 2.8424 | |
| MCF 10A | NM | Basal B | L-779450 | BRAF | MAPK | 11056.149 | uM | 17.45540 | 44.1580 | 0.1958 | -0.9043 | 1.1127 | 0.0672 | 0.9888 | 2.9204 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7484.098 | uM | inf | inf | 0.9819 | 0.9819 | 0.0000 | 0.0183 | 0.3261 | 2.6137 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7483.098 | uM | inf | 6.76260 | 0.9078 | 0.8513 | 0.5088 | 0.0205 | 0.9339 | 3.1224 | |
| MCF 10A | NM | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7485.098 | uM | 7.85490 | 5.83020 | 0.3398 | 0.3231 | 3.4858 | 0.0601 | 0.9946 | 3.3725 | |
| MCF 10A | NM | Basal B | LBH589 | HDAC | HDAC | 11056.154 | uM | 0.19038 | 0.33191 | -0.5925 | -0.5986 | 1.4162 | 0.5725 | 0.9985 | 2.9341 | |
| MCF 10A | NM | Basal B | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 11056.154 | uM | 1.11180 | 5.18750 | -0.6144 | -1.0000 | 0.7133 | 0.3656 | 0.9875 | 2.9341 | |
| MCF 10A | NM | Basal B | Mebendazole | 12944.174 | uM | 5.09360 | 7.17890 | -0.0457 | -0.1840 | 0.9131 | 0.2211 | 0.9985 | 2.7985 | |||
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 7483.084 | uM | inf | inf | 0.9515 | 0.9515 | 0.0000 | 0.0312 | -0.0222 | 3.2830 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 7485.085 | uM | inf | 0.00667 | 0.5314 | 0.5163 | 5.0000 | 0.4051 | 0.9118 | 3.6369 | |
| MCF 10A | NM | Basal B | Methotrexate | DHFR | Metabolism | 7484.084 | uM | 0.05274 | 0.04202 | 0.4113 | 0.3396 | 4.9999 | 0.4544 | 0.9346 | 2.6217 | |
| MCF 10A | NM | Basal B | Methylglyoxal | 13551.184 | uM | 680.90370 | 999.99950 | -0.2926 | -0.2104 | 0.9138 | 0.3902 | 0.9470 | 3.0171 | |||
| MCF 10A | NM | Basal B | MG-132 | Proteasome | Proteasome | 14215.189 | uM | inf | inf | -0.0224 | -0.0224 | 0.0000 | 0.5675 | 0.5599 | 3.3654 | |
| MCF 10A | NM | Basal B | MG-132 | Proteasome | Proteasome | 14215.189 | uM | inf | inf | -0.0224 | -0.0224 | 0.0000 | 0.5675 | 0.5599 | 3.3654 |