Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Cell Clinical Subtype Transcriptional Subtype Small Molecule Antibody Perturbagen Target Perturbagen Class Biological Replicate ID Conc Unit GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR r2 Nominal Division Rate
MCF12A
NM
Basal B
 17-AAG
HSP90
HSP90
7873.04
uM
0.07777
0.10717
 -0.7837 -0.5081 2.1861 0.7784
0.9775
 2.1738
MCF12A
NM
Basal B
 17-AAG
HSP90
HSP90
7491.05
uM
0.01557
0.03316
 -0.9997 -1.0000 1.4537 1.2798
0.9830
 0.5814
MCF12A
NM
Basal B
 2-deoxyglucose
12949.177
uM
1068.11960
999.58210
 0.1328 0.1289 4.4961 0.1401
0.8220
 1.7727
MCF12A
NM
Basal B
 5-DFUR
TYMS
TYMS
10817.143
uM
25.65560
213.55380
 -0.8227 -1.0000 0.5184 0.5449
0.9767
 1.5734
MCF12A
NM
Basal B
 5-DFUR
TYMS
TYMS
12365.143
uM
22.40880
268.29440
 -0.6111 -1.0000 0.4425 0.5407
0.9913
 2.3865
MCF12A
NM
Basal B
 5-FU
TYMS
TYMS
7873.017
uM
25.41720
95.28780
 -0.8046 -0.9005 0.7794 0.7892
0.9822
 2.2073
MCF12A
NM
Basal B
 Afatinib
EGFR/HER2
ErbB
12365.165
uM
0.13682
1.2490
 -0.8289 -1.0000 0.4968 0.6460
0.9670
 1.9114
MCF12A
NM
Basal B
 AG1024
IGF1R
RTK
7490.066
uM
14.17670
6.80550
 0.4159 0.3966 2.1469 0.0973
0.9729
 2.4829
MCF12A
NM
Basal B
 AG1024
IGF1R
RTK
7489.066
uM
5.58310
4.34950
 0.2017 0.1806 1.7948 0.1286
0.9932
 2.3124
MCF12A
NM
Basal B
 AG1478
EGFR
ErbB
7873.016
uM
0.75561
0.65943
 0.0848 0.1777 3.2239 0.3539
0.9538
 2.1516
MCF12A
NM
Basal B
 AG1478
EGFR
ErbB
7491.016
uM
0.06221
0.17441
 -0.8820 -0.8372 0.9542 0.9909
0.9929
 0.6625
MCF12A
NM
Basal B
 AS-252424
PI3K
PI3K
10817.153
uM
26.10610
163.88750
 0.4381 -1.0000 0.5980 0.1049
0.9395
 1.6726
MCF12A
NM
Basal B
 AS-252424
PI3K
PI3K
12365.165
uM
34.21190
35.76550
 0.5367 -0.1243 5.0000 0.0091
0.9694
 1.9114
MCF12A
NM
Basal B
 Baicalein
Lipoxygenase
Metabolism
10817.072
uM
20.08060
22.44620
 -0.1534 -0.1612 2.5086 0.2393
0.9661
 1.6247
MCF12A
NM
Basal B
 Baicalein
Lipoxygenase
Metabolism
7490.073
uM
12.09260
9.68970
 0.2195 0.2169 2.5670 0.1821
0.9937
 2.4641
MCF12A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
14912.203
uM
0.47060
2.06830
 -0.7111 -0.9364 0.7128 0.5758
0.9819
 2.1925
MCF12A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
14912.203
uM
0.47060
2.06830
 -0.7111 -0.9364 0.7128 0.5758
0.9819
 2.1925
MCF12A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
7490.074
uM
1.25240
10.97030
 -0.5514 -0.9854 0.5017 0.4927
0.9873
 2.6912
MCF12A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
7490.074
uM
1.25240
10.97030
 -0.5514 -0.9854 0.5017 0.4927
0.9873
 2.6912
MCF12A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
7489.074
uM
0.08785
0.26282
 -0.8460 -0.8530 0.9084 0.9267
0.9996
 2.1617
MCF12A
NM
Basal B
 Bortezomib
Proteasome
Proteasome
7489.074
uM
0.08785
0.26282
 -0.8460 -0.8530 0.9084 0.9267
0.9996
 2.1617
MCF12A
NM
Basal B
 Bosutinib
Src
nRTK
10817.145
uM
0.89628
1.6540
 -0.5908 -0.5784 1.2545 0.5408
0.9886
 1.5564
MCF12A
NM
Basal B
 Bosutinib
Src
nRTK
12365.17
uM
1.38390
1.83440
 -0.4017 -0.4195 2.1617 0.3543
0.9922
 2.2930
MCF12A
NM
Basal B
 Bromopyruvic acid
Hexokinase II
Metabolism
12949.177
uM
0.02170
0.02654
 -0.9278 -0.8691 5.0000 1.0283
0.9974
 1.7727
MCF12A
NM
Basal B
 Carboplatin
DNA cross-linker
DNA cross-linker
10061.12
uM
180.30870
388.26890
 -0.7598 -1.0000 1.4323 0.2270
0.9929
 2.0669