Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | Temsirolimus | MTOR | MTOR | 12254.144 | uM | 1.92370 | 93.31480 | -0.2947 | -1.0000 | 0.2830 | 0.3903 | 0.8396 | 1.8842 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 7872.007 | uM | 0.22414 | 0.42287 | -0.5750 | -0.2639 | 0.6677 | 0.5877 | 0.8723 | 1.7126 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 9566.121 | uM | 0.50890 | 6.38250 | -0.6225 | -1.0000 | 0.4344 | 0.5281 | 0.9860 | 2.3089 | |
| MCF 10F | NM | - | Topotecan | TOP1 | TOP | 7488.078 | uM | 0.05315 | 0.94334 | -0.7292 | -1.0000 | 0.3820 | 0.7796 | 0.9927 | 1.5130 | |
| MCF 10F | NM | - | Torkinib | 15393.211 | uM | 0.0020 | 0.00328 | -0.1907 | -0.1572 | 0.5522 | 0.8375 | 0.9925 | 1.6449 | |||
| MCF 10F | NM | - | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 12254.16 | uM | 8.0680 | 8.73180 | -0.1701 | -0.1770 | 3.8335 | 0.0845 | 0.9915 | 1.4029 | |
| MCF 10F | NM | - | TPCA-1 | IKK | NFKB | 7486.1 | uM | 6.33670 | 8.20350 | -0.3011 | -0.2912 | 1.7776 | 0.2506 | 0.9936 | 1.0281 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 7488.05 | uM | 0.00327 | 0.00485 | -0.3028 | -0.2479 | 1.0200 | 0.8010 | 0.9782 | 1.3218 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 7871.05 | uM | 0.00704 | 0.00891 | -0.1722 | -0.1373 | 1.0316 | 0.6760 | 0.9917 | 1.2892 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 7872.05 | uM | 0.01741 | 0.01676 | 0.0286 | 0.0236 | 1.2607 | 0.5109 | 0.9925 | 1.4902 | |
| MCF 10F | NM | - | Trametinib | MEK | MAPK | 9566.012 | uM | 0.01217 | 0.01213 | -0.0215 | 0.0027 | 1.6371 | 0.5555 | 0.9954 | 2.2335 | |
| MCF 10F | NM | - | Trastuzumab | HER2 | ErbB | 9566.026 | uM | inf | inf | 0.9681 | 0.9681 | 0.0000 | -0.0233 | -0.7310 | 2.1367 | |
| MCF 10F | NM | - | Trastuzumab | HER2 | ErbB | 7487.102 | uM | 5.78510 | 28.60730 | 0.4084 | -1.0000 | 0.6873 | 0.0988 | 0.8554 | 1.5273 | |
| MCF 10F | NM | - | Trichostatin A | HDAC | HDAC | 7486.065 | uM | 52.68520 | 91.22780 | -0.9164 | -0.9036 | 1.8800 | 0.5652 | 0.9979 | 1.1517 | |
| MCF 10F | NM | - | Triciribine | AKT | AKT | 7487.074 | uM | 0.02502 | 0.18177 | -0.6575 | -0.7864 | 0.4765 | 0.7450 | 0.9603 | 1.4197 | |
| MCF 10F | NM | - | Valproic acid | HDAC | HDAC | 12254.143 | uM | 702.26870 | 1000.00000 | -0.9090 | -0.2550 | 1.1661 | 0.1906 | 0.6277 | 1.4110 | |
| MCF 10F | NM | - | Vinorelbine | TUBB | TUBB | 7872.042 | uM | 0.01453 | 0.01729 | -0.8594 | -0.1474 | 1.4830 | 0.6638 | 0.7593 | 1.3632 | |
| MCF 10F | NM | - | Vinorelbine | TUBB | TUBB | 7871.018 | uM | 0.01164 | 0.01491 | -0.9072 | -0.2725 | 1.7569 | 0.7399 | 0.8517 | 1.1973 | |
| MCF 10F | NM | - | Vorinostat | HDAC | HDAC | 7486.065 | uM | 702.86880 | 1000.00000 | -0.8187 | -0.6947 | 2.4705 | 0.3401 | 0.9903 | 1.1517 | |
| MCF 10F | NM | - | XRP44X | ELK3 | MAPK | 12254.157 | uM | inf | 2.29620 | 0.7352 | 0.7614 | 1.2234 | 0.0586 | 0.9093 | 1.6969 | |
| MCF 10F | NM | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14161.189 | uM | 0.23276 | 0.47348 | -0.9169 | -0.9512 | 1.5006 | 0.7755 | 0.9969 | 1.1003 | |
| MCF 10F | NM | - | ZM-447439 | AURK | AURK | 12254.16 | uM | inf | 2.36150 | 0.5734 | 0.7090 | 5.0000 | 0.0457 | 0.7984 | 1.4029 | |
| MCF12A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7491.016 | uM | 1.54520 | 1.21350 | 0.1999 | 0.3506 | 5.0000 | 0.3099 | 0.7006 | 0.6625 | ||
| MCF12A | NM | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7873.016 | uM | 14.21690 | 20.24340 | -0.8431 | -0.8481 | 2.8065 | 0.3039 | 0.9986 | 2.1516 | ||
| MCF12A | NM | Basal B | 17-AAG | HSP90 | HSP90 | 10061.037 | uM | 0.03509 | 0.03844 | -0.6495 | -0.2882 | 5.0000 | 0.8377 | 0.6366 | 1.7478 |